A5038194791- interferon and immune responses
- Cancer-related molecular mechanisms research
- Immune Response and Inflammation
- Retinal Development and Disorders
- RNA Research and Splicing
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA regulation and disease
- Cytokine Signaling Pathways and Interactions
- Cell Adhesion Molecules Research
- Zebrafish Biomedical Research Applications
- Neurogenesis and neuroplasticity mechanisms
- Inflammasome and immune disorders
- Immunotherapy and Immune Responses
- Galectins and Cancer Biology
- Glycosylation and Glycoproteins Research
- Medicinal Plants and Bioactive Compounds
- Nerve injury and regeneration
- Radioactivity and Radon Measurements
- Carbohydrate Chemistry and Synthesis
- RNA modifications and cancer
- Cancer-related Molecular Pathways
- Mesenchymal stem cell research
- Tuberculosis Research and Epidemiology
- Proteoglycans and glycosaminoglycans research
- Endoplasmic Reticulum Stress and Disease
Nantong University
2016-2025
First Affiliated Hospital of Shihezi University Medical College
2025
Affiliated Hospital of Nantong University
2025
Ministry of Education of the People's Republic of China
2025
Anhui Medical University
2025
Huzhou University
2024
Southern Medical University
2020-2024
Nantong Maternity and Child Health Hospital
2023-2024
Anyang Hospital of Traditional Chinese Medicine
2024
Shanghai Sunshine Rehabilitation Center
2024
Article29 August 2018Open Access Source DataTransparent process Function of HNRNPC in breast cancer cells by controlling the dsRNA-induced interferon response Yusheng Wu Tsinghua-Peking Joint Center for Life Sciences, Beijing, China MOE Key Laboratory Bioinformatics, Tsinghua University, Synthetic & Systems Biology, School Search more papers this author Wenwei Zhao Yang Liu Graduate Program Peking-Tsinghua-National Institute Biological Science, Xiangtian Tan Xin Li Qin Zou Zhengtao Xiao Hui...
Mitochondrial antiviral signaling (MAVS) protein is required for innate immune responses against RNA viruses. In virus-infected cells MAVS forms prion-like aggregates to activate cascades, but the underlying structural mechanism unknown. Here we report cryo-electron microscopic structures of helical filaments formed by both N-terminal caspase activation and recruitment domain (CARD) a truncated lacking part proline-rich region C-terminal transmembrane domain. Both are left-handed...
Abstract The long noncoding RNA nuclear-enriched abundant transcript 1 (NEAT1) has been shown to regulate multiple cancer-related cellular activities including cell proliferation, apoptosis, and migration. In this study, we confirm that repression of NEAT1 induces DNA damage, disturbs the cycle, arrests proliferation prostate cancer cells. By taking advantage tumor transcriptome profiles from Cancer Genome Atlas, our data-mining pipeline identified a series transcription factors (TF) whose...
To investigate the effect of IRE1α/TRAF2/NF-κB pathway on early brain injury. An endovascular puncture model subarachnoid hemorrhage (SAH) was developed and SAH grading performed. The following groups experimental animals were randomly assigned: Blank group, Sham SAH+ DMSO SAH+STF-083010(IRE1α inhibitor) SAH+BAY11-7082(NF-κB group. Neurological deficits assessed in animal models using a modified Garcia score. expression IRE1α, GRP78, TRAF2, NF-κB, caspase3 measured western blot analysis....
Staphylococcus aureus infections are associated with diverse clinical manifestations leading to significant morbidity and mortality. To define the role of host response in disease, we characterized whole blood transcriptional profiles children hospitalized community-acquired S. infection phenotyped bacterial strains isolated. The overall was by over-expression innate immunity hematopoiesis related genes under-expression adaptive immunity. We assessed individual using modular fingerprints...
About half of all subjects with common variable immune deficiency (CVID) are afflicted inflammatory complications including hematologic autoimmunity, granulomatous infiltrations, interstitial lung disease, lymphoid hyperplasia and/or gastrointestinal disease. The pathogenesis these conditions is poorly understood but singly and in aggregate, lead to significantly increased (11 fold) morbidity mortality, not experienced by CVID without complications. To explore the dysregulated networks...
Abstract Upon retina injury, Müller glia in the zebrafish respond by generating multipotent progenitors to repair retina. However, complete mechanisms underlying regeneration remain elusive. Here we report inflammation‐induced mammalian target of rapamycin (mTOR) signaling is essential for adult zebrafish. We show after a stab mTOR rapidly activated and later glia‐derived progenitor cells (MGPCs). Importantly, required dedifferentiation, as well proliferation MGPCs. Interestingly, transient...
Abstract Fbxo45, a conserved F-box protein, comprises of an atypical SKP1, CUL1, protein (SCF) ubiquitin ligase complex that promotes tumorigenesis and development. However, the biological function molecular mechanisms Fbxo45 involved in pancreatic carcinogenesis are ambiguous. We conducted several approaches, including transfection, coIP, real-time polymerase chain reaction (RT-PCR), Western blotting, assays, animal studies, to explore role cancer. Here, we report USP49 stability is...
Ganoderic acid A is a lanostane triterpene isolated from Ganoderma lucidum. It has been reported to exhibit antitumor activity, which mainly mediated through its inhibitory effect on nuclear transcription factor-kappaB and activator protein-1. But the role of ganoderic in JAK-STAT3 signaling pathways still unclear. In present study, we investigated signal transducer 3 pathway evaluated whether suppression activity by could sensitize HepG2 cells cisplatin. Our results show that significantly...
Background: Widespread death of implanted cells hampers the development stem cell therapy for acute myocardial infarction (AMI). Our previous studies indicated that statins can protect mesenchymal (MSCs) against post-infarct microenvironment, thus increasing therapeutic effect. However, underlying mechanisms are unclear. The JAK-STAT pathway participates in regulation stress responses myocardium to various insults. This study aimed detect whether rosuvastatin (ROSU) facilitates survival,...
Abstract The mechanisms by which microbial vaccines interact with human APCs remain elusive. Herein, we describe the transcriptional programs induced in DCs pathogens, innate receptor ligands and vaccines. Exposure of to influenza, Salmonella enterica Staphylococcus aureus allows us build a modular framework containing 204 transcript clusters. We use this characterize responses monocytes, monocyte-derived blood DC subsets 13 Different induce distinct based on pathogen type, adjuvant...
Abstract Fundamental processes such as ribosomal RNA synthesis and chromatin remodeling take place in the nucleolus, which is hyperactive fast-proliferating cells. The sophisticated regulatory mechanism underlying dynamic nucleolar structure functions yet to be fully explored. present study uncovers mutual functional dependency between a previously uncharacterized human long non-coding RNA, we renamed LETN , key protein, NPM1. Specifically, being upregulated multiple types of cancer, resides...
Neuroinflammation is a feature common to neurodegenerative diseases, such as Parkinson’s disease (PD), which might be responsive therapeutic intervention. Rotenone has been widely used establish PD models by inducing mitochondrial dysfunction and inflammation. Our previous studies have reported that pyrroloquinoline quinone (PQQ), naturally occurring redox cofactor, could prevent in rotenone induced regulating functions. In the present study, we aimed investigate effect of PQQ on...
JOURNAL/nrgr/04.03/01300535-202512000-00031/figure1/v/2025-01-31T122243Z/r/image-tiff Inflammation plays a crucial role in the regeneration of fish and avian retinas. However, how inflammation regulates Müller glia (MG) reprogramming remains unclear. Here, we used single-cell RNA sequencing to investigate cell heterogeneity interactions MG immune cells regenerating zebrafish retina. We first showed that two types quiescent (resting MG1 MG2) reside uninjured Following retinal injury, resting...
Long noncoding (lnc)RNAs have been implicated in the development and progression of atherosclerosis. However, expression mechanism action lncRNAs atherosclerosis are still unclear. We implemented microarray analysis human advanced atherosclerotic plaques normal arterial intimae to detect lncRNA mRNA profile. Gene Ontology functional enrichment pathway analyses were applied explore potential functions pathways involved pathogenesis A total 236 488 mRNAs selected for further Ingenuity Pathway...
Abstract O-GlcNAcylation is a unique monosaccharide modification that ubiquitously present in numerous nucleoplasmic and mitochondrial proteins. The hexosamine biosynthesis pathway (HBP), which key branch of glycolysis, provides the sugar donor UDP-GlcNAc for O-GlcNAc modification. Thus, HBP/O-GlcNAcylation can act as nutrient sensor to perceive changes levels trigger modifications functional proteins cellular (patho-)physiology, thereby regulating diverse metabolic processes. An imbalance...