A5018489971- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Glioma Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- RNA modifications and cancer
- Autophagy in Disease and Therapy
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- Cancer-related Molecular Pathways
Third Xiangya Hospital
2024-2025
Central South University
2024-2025
Bengbu Medical College
2022
Abstract Fbxo45, a conserved F-box protein, comprises of an atypical SKP1, CUL1, protein (SCF) ubiquitin ligase complex that promotes tumorigenesis and development. However, the biological function molecular mechanisms Fbxo45 involved in pancreatic carcinogenesis are ambiguous. We conducted several approaches, including transfection, coIP, real-time polymerase chain reaction (RT-PCR), Western blotting, assays, animal studies, to explore role cancer. Here, we report USP49 stability is...
Glioma is the primary malignant tumor with highest incidence rate in adult central nervous system. The application of bioinformatics methods to analyze RNA sequences multiple gliomas revealed that CDT1 gene has a significant impact on cell cycle glioma cells. Subsequently, we comprehensively and systematically investigated expression through analysis, clinical tissue specimens, vitro functional experiments. Our study first report glioma. findings demonstrate plays crucial role proliferation...