A5101682584- Supramolecular Self-Assembly in Materials
- Cardiovascular Function and Risk Factors
- Metabolism, Diabetes, and Cancer
- Signaling Pathways in Disease
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Luminescence and Fluorescent Materials
- Autophagy in Disease and Therapy
- Ubiquitin and proteasome pathways
- Synthesis and Properties of Aromatic Compounds
- Nitric Oxide and Endothelin Effects
- Hormonal Regulation and Hypertension
- Lipid metabolism and disorders
- Connexins and lens biology
- Estrogen and related hormone effects
- Cellular Mechanics and Interactions
- Adrenal Hormones and Disorders
- Circular RNAs in diseases
- Blood Coagulation and Thrombosis Mechanisms
- Erythrocyte Function and Pathophysiology
- Ferroptosis and cancer prognosis
- Selenium in Biological Systems
- Thyroid Disorders and Treatments
- Hydrogels: synthesis, properties, applications
- Biomedical Research and Pathophysiology
- Nerve injury and regeneration
Xinxiang Medical University
2025
Shuguang Hospital
2019-2024
Shanghai University of Traditional Chinese Medicine
2019-2024
Shandong University
2023-2024
Bengbu Medical College
2021-2023
Wannan Medical College
2023
Qingdao University
2019-2020
Affiliated Hospital of Qingdao University
2020
Qingdao Municipal Hospital
2019
Cangzhou Central Hospital
2014-2018
Abstract Fbxo45, a conserved F-box protein, comprises of an atypical SKP1, CUL1, protein (SCF) ubiquitin ligase complex that promotes tumorigenesis and development. However, the biological function molecular mechanisms Fbxo45 involved in pancreatic carcinogenesis are ambiguous. We conducted several approaches, including transfection, coIP, real-time polymerase chain reaction (RT-PCR), Western blotting, assays, animal studies, to explore role cancer. Here, we report USP49 stability is...
Antithrombin (AT) is a protein of the serpin superfamily involved in regulation proteolytic activity serine proteases coagulation system. AT known to exhibit anti-inflammatory and cardioprotective properties when it binds heparan sulfate proteoglycans (HSPGs) on vascular cells. AMP-activated kinase (AMPK) plays an important role during myocardial ischaemia reperfusion (I/R). To determine whether signaling function mediated through AMPK pathway, we evaluated activities wild-type its two...
Background.Hypertrophy of glomerular mesangial cells (GMC) is one the earliest pathological abnormalities in diabetic nephropathy, which correlates with eventual glomerulosclerosis. We have previously proved that this hypertrophy mediated by downregulation connexin43 (Cx43) and dysfunction gap junctional intercellular communication, but mechanism involved still unclear. This study aims to investigate whether PTEN/Akt/mammalian target rapamycin (mTOR) was as downstream molecular signaling...
Multiple constituent coassembly is an emerging strategy to manipulate supramolecular chirality and chiroptical properties such as circularly polarized luminescence (CPL). However, the second or third could not be removed from pristine self-assembly. Here we developed a constitute-removable chiral using sublimation that realize with tunable chirality, CPL properties. Octafluoronapthalene (OFN) small enthalpy formed coassemblies perylene-conjugated peptoids via arene-perfluoroarene (AP)...
As one of the most serious microvascular complications diabetes and a major cause end stage renal disease, diabetic nephropathy (DN) is calling for effective treatment strategies. Here, we provide evidence that hyperglycemia can induce proliferation decreasing apoptosis mesangial cells (MCs) subsequent dysfunction by up-regulating cellular FLICE-inhibitory protein (cFLIP). Treatment with emodin significantly turns down accelerated cell cycle MCs cultured in high glucose (HG) via inhibiting...
Shengmai injection (SMI), a traditional Chinese herbal medicine extracted from Panax ginseng C.A. Mey., Ophiopogon japonicus (Thunb.) Ker Gawl., and Schisandra chinensis (Turcz.) Baill., has been used to treat acute chronic heart failure. This study aimed further clarify the effects of SMI on energy metabolism. could improve cell-survival rate also reduce myocardial cell hypertrophy apoptosis. Mitochondria are important sites cellular metabolism, protects mitochondrial function which was...
Abstract Psoriasis is a persistent immune-mediated inflammatory dermatosis. The treatment of psoriasis now features natural medicine as an effective new alternative because its notable effectiveness and few side effects. Nervonic acid (NA), long-chain fatty mostly sourced from the seed oils some wild plants, exhibits significant antidepressant anti-inflammatory properties. Nonetheless, pathogenic effects mechanism NA in pathogenesis are unreported. This work demonstrated that markedly...
The dynamic mechanical strength of the extracellular matrix (ECM) has been demonstrated to play important role in determining cell behavior. Growing evidences suggest that gradual stiffening process is particularly decisive during tissue development and wound healing. Herein, a novel strategy prepare hydrogels with gradually enhanced provided. Such could maintain properties at their initial states, such as self-healing shear-thinning properties. With subsequent slow covalent crosslinking,...
Nitric oxide synthase-interacting protein (Nosip) interacts with nitric synthase (NOS) and regulates NO synthesis release, which participates in various critical physiological pathological processes. However, the role of Nosip hepatocellular carcinoma (HCC) is unclear. In this study, expression was found to be elevated HCC tissues cells. siRNA transfection inhibited proliferation motility cells promoted apoptosis. contrast, overexpression migration invasion, apoptosis As a natural compound,...
Abstract Multiple constituent coassembly is an emerging strategy to manipulate supramolecular chirality and chiroptical properties such as circularly polarized luminescence (CPL). However, the second or third could not be removed from pristine self‐assembly. Here we developed a constitute‐removable chiral using sublimation that realize with tunable chirality, CPL properties. Octafluoronapthalene (OFN) small enthalpy formed coassemblies perylene‐conjugated peptoids via arene‐perfluoroarene...
Abstract Background Dilated cardiomyopathy (DCM) is a severe condition characterized by cardiac enlargement and declining heart function, often leading to refractory failure life-threatening outcomes. Globally, particularly in China, notable challenge arises from the insufficient availability of targeted therapies demonstrating significant efficacy for DCM. Additionally, application traditional anti-heart drugs DCM constrained, as many patients exhibit propensity hypotension or show limited...
Introduction: Antithrombin (AT) is an endogenous protein of the serpin superfamily involved in regulation proteolytic activity serine proteases coagulation system. In addition to its anticoagulant function, AT also exhibits anti-inflammatory and cardioprotective function when it binds distinct heparin sulfate proteoglycans (HSPG) on vascular endothelial cells. The energy sensor AMP-activated kinase (AMPK) known play important role during myocardial ischemia reperfusion (I/R). Hypothesis: may...
To explore the molecular mechanism by which natural astaxanthin (AST) inhibits renal clear cell carcinoma (KIRC) based on network pharmacology and bioinformatics.PharmMapper database was used to retrieve targets of astaxanthin, TCGA identify differentially expressed genes (DEGs) in KIRC adjacent tissues. The target AST analyzed using Cytoscape software construct "drug-target" diagram. visual protein-protein interaction (PPI) constructed String database, GO enrichment analysis core performed....
Antithrombin (AT) is a plasma serpin inhibitor that regulates the proteolytic activity of procoagulant proteases clotting cascade. In addition to its anticoagulant activity, AT also possesses potent antiinflammatory and antiangiogenic properties. this study, we investigated wild-type (AT-WT) reactive center loop mutant (AT-RCL) not capable inhibiting thrombin in mouse model ischemia/reperfusion injury which left anterior descending coronary artery (LAD) was occluded released then. The...