A5100715582- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Metabolism, Diabetes, and Cancer
- Retinal Diseases and Treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Nitric Oxide and Endothelin Effects
- Mitochondrial Function and Pathology
- PI3K/AKT/mTOR signaling in cancer
- Cardiac Fibrosis and Remodeling
- Circular RNAs in diseases
- Sirtuins and Resveratrol in Medicine
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Kruppel-like factors research
- Inflammasome and immune disorders
- Fungal and yeast genetics research
- Plant Pathogens and Fungal Diseases
- Heart Rate Variability and Autonomic Control
- Advanced biosensing and bioanalysis techniques
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Tissue Engineering and Regenerative Medicine
- Cardiovascular Function and Risk Factors
- Vitamin C and Antioxidants Research
- bioluminescence and chemiluminescence research
- Mycotoxins in Agriculture and Food
University at Buffalo, State University of New York
2015-2024
Hebei Medical University
2022-2024
Second Hospital of Hebei Medical University
2022-2024
Tongji Hospital
2017-2024
Huazhong University of Science and Technology
2017-2024
Guangxi University
2023
Nankai University
2023
Jinhua Polytechnic
2023
First People's Hospital of Yunnan Province
2011-2022
Kunming University of Science and Technology
2022
Mesenchymal stem cell (MSC)-derived exosomes mediate tissue regeneration in a variety of diseases including ischemic heart injury, liver fibrosis, and cerebrovascular disease. Despite an increasing number studies reporting the therapeutic effects MSC exosomes, underlying molecular mechanisms their miRNA complement are poorly characterized. Here we microRNA (miRNA)-profiled conducted network analysis to identify dominant biological processes pathways modulated by exosomal miRNAs. At system...
A limitation of using exosomes to their fullest potential is limited secretion from cells, a major bottleneck efficient exosome production and application. This especially true for mesenchymal stem cells (MSCs), which can self-renew but have expansion capacity, undergoing senescence after only few passages, with derived senescent showing impaired regenerative capacity compared young cells. Here, we examined the effects small molecule modulators capable enhancing MSCs. The treatment MSCs...
The regulation of AMPK in the ischemic heart remains incompletely understood. Recent evidence implicates role Sestrin2 signaling pathway, and it is hypothesized that plays an influential during myocardial ischemia to promote activation. protein was found be expressed adult cardiomyocytes accumulated conditions. knockout (KO) mice were used determine importance reperfusion (I/R) injury. When wild-type (WT) KO subjected vivo I/R, infarct size significantly greater compared with WT hearts....
Abstract A limitation to using exosomes their fullest potential is limited secretion from cells, a major bottleneck efficient exosome production and application. This especially true for mesenchymal stem cell (MSCs), which can self-renew but have expansion capacity, undergoing senescence after only few passages, with derived senescent cells showing impaired regenerative capacity compared young cells. Here we examined the effects of small molecule modulators capable enhancing MSCs. Treatment...
NADPH oxidase 4 (Nox4) is a major source of reactive oxygen species (ROS) in retinal endothelial cells (ECs) and upregulated under hyperglycemic hypoxic conditions. However, the role Nox4 upregulation long-term blood vessel damage diabetic retinopathy (DR) remains undefined. Here, we attempted to address this question using humanized EC-specific transgenic (hNox4EC-Tg) knockout (Nox4EC-KO) mouse models. Our results show that hNox4EC-Tg mice at age 10–12 months exhibited increased tortuosity...
Ras GTPases act as molecular switches to control various cellular processes by coupling integrated signals in eukaryotes. Activities of are triggered GTPase guanine nucleotide exchange factors (RasGEFs) general, whereas the role RasGEF plant pathogenic fungi is largely unknown. In this study, we characterized only protein Fusarium graminearum, FgCdc25, combining genetic, cytological and phenotypic strategies. FgCdc25 directly interacted with RasGTPase FgRas2, but not FgRas1, regulate growth...
Abstract OBJECTIVE Vascular calcification (VC) significantly contributes to cardiovascular morbidity and mortality escalates with age. However, effective pharmaceutical interventions are lacking, the molecular mechanisms linking aging VC remain elusive. This study explores role of nuclear factor erythroid 2-related 2 (NRF2) in VC, specifically focusing on interplay between vascular senescence oxidative stress (OS). APPROACH AND RESULTS Using a chronological mouse model, we noted significant...
Colorectal cancer (CRC) is an extremely malignant tumor with a high mortality rate. Little known about the mechanism by which forkhead Box q1 (FOXQ1) causes CRC invasion and metastasis through epidermal growth factor receptor (EGFR) pathway.To illuminate FOXQ1 promotes of activating heparin binding (HB-EGF)/EGFR pathway.We investigated differential expression prognosis HB-EGF in using Gene Expression Profiling Interactive Analysis (GEPIA) website (http://gepia.cancer-pku.cn/index.html)....
Nuclear factor E2-related 2 (Nrf2) is a transcription known to induce the expression of variety antioxidant and detoxification genes. Recently, increasing evidence has revealed roles for Nrf2 in glucose, lipid, energy metabolism; however, exact functions hepatocyte biology are largely unclear. In current study, transient knockdown via siRNA transfection enhanced glucose uptake fasting AML12 hepatocytes 325.3 ± 11.1% ( P < 0.05) that untransfected control cells. The impacts (NK) on system,...
Li, Zongbin, Jun Guo, Chunwei Liu, Yajun Shi, Yang Jinli Wang, Dandan Jing and Yundai Chen. Compound Danshen Dripping Pill promotes adaptation to acute high-altitude exposure. High Alt Med Biol. 21:258–264, 2020. Background: In this study, we aimed investigate whether the traditional Chinese medicine, (CDDP), can prevent mountain sickness (AMS). We allocated CDDP matching placebos 160 volunteers before they ascended a high altitude. Treadmill exercise tests, echocardiography, blood routine...
Objective: To investigate the efficiency and potential mechanisms of exosomes from dendritic cells (DCs) transfected with Forkhead box protein P3 (FOXP3) in development experimental autoimmune encephalomyelitis (EAE). Method: Mouse bone marrow-derived immature DCs were loaded adenovirus carrying FOXP3 gene, generated. Then (FOXP3-EXOs) co-cultured CD4+T cell vitro to evaluate their on proliferation differentiation, injected into EAE mice assess effects EAE. Result: FOXP3-EXOs effective...
The modified rougan decoction (MRGD) compound formula has been proven a certain ability to relieve lipopolysaccharide-enrofloxacin (LPS-ENR)-induced liver oxidant injury in chickens. Recent advances have shown that mitochondrial dysfunction affects the development of many diseases, leading increased interest exploring its effects. Using LPS-ENR-injured vivo and vitro further evaluate effects MRGD on structure function, emphasized investigation molecular mechanism. After LPS-ENR treatment,...