A5101664045- Circadian rhythm and melatonin
- Dietary Effects on Health
- Sleep and Wakefulness Research
- Genetics, Aging, and Longevity in Model Organisms
- Cancer-related molecular mechanisms research
- Psychological and Temporal Perspectives Research
- MicroRNA in disease regulation
- Kruppel-like factors research
- Sleep and related disorders
- Winter Sports Injuries and Performance
- Vitamin C and Antioxidants Research
- Spaceflight effects on biology
- Immune cells in cancer
- Epigenetics and DNA Methylation
- Neuroinflammation and Neurodegeneration Mechanisms
- Sports injuries and prevention
- Health, Environment, Cognitive Aging
- Neurobiology and Insect Physiology Research
- Effects and risks of endocrine disrupting chemicals
- Educational Robotics and Engineering
- Cancer Immunotherapy and Biomarkers
- Coenzyme Q10 studies and effects
- Genomics, phytochemicals, and oxidative stress
Third Xiangya Hospital
2025
Xiangya Hospital Central South University
2025
Beijing Jiaotong University
2025
Zunyi Medical University
2024
Sichuan University
2017-2020
West China Medical Center of Sichuan University
2017-2020
Although previous studies investigated the potential adverse effects of endocrine-disrupting chemicals (EDCs) on biological age acceleration and aging-related diseases, mixed effect multiple types EDCs acceleration, including its underlying mechanism, remains unclear. Data from National Health Nutrition Examination Survey (NHANES) were used to analyze measures, Klemera-Doubal method (KDM-BA), phenotypic age, homeostatic dysregulation (HD). Weight quantile sum (WQS) regression was performed...
Abstract The tumor microenvironment is associated with various progressions, including cancer metastasis, immunosuppression, and sustained growth. Tumor‐associated macrophages (TAMs) are considered an indispensable component of the microenvironment, participating in progression remodeling creating compounds to regulate activities. This study aims observe enriched TAMs tissues during bladder development, which markedly facilitated proliferation cells promoted growth vivo. We determined that...
Transactivator (Tat), a regulatory protein of HIV-1, plays very important role in HIV-1 infection by promoting the rapid replication HIV. Research surrounding Tat function has mainly focused on inhibition immune system, promotion growth vascular endothelial cells, and nervous system damage. To date, little research addressed circadian rhythms. Previous studies our lab have found that concentration HIV patients' blood was positively correlated with sleep quality melatonin concentrations. In...
Emerging evidence has demonstrated that long noncoding RNAs (lncRNAs) play critical roles in the epigenetic and transcriptional regulation of mammalian circadian systems. Circadian rhythmicity regulates many aspects our immune system, perturbation clock can augment inflammatory response. However, knowledge precise functions lncRNAs within system is relatively limited. In this study, differentially expressed induced by Clock knockdown were screened via mRNA/lncRNA microarray bioinformatic...
The circadian system regulates many important aspects of physiology, including the immune response to infectious agents, which is mediated by activation transcription factor NF-κB. Thus, understanding mechanisms clocks regulate NF-κB a necessary step toward development improved therapies underwritten manipulation. Previous reports have identified OTUD7B deubiquitinase, as novel regulator noncanonical signaling, largely through maintenance TRAF3, negative In investigations in our laboratory,...
Social isolation usually affects the physical and mental health of human produces depression, whether it may relate with circadian rhythm still remains to be investigated. Two groups mice were employed this experiment continuously monitoring their activities in a dark environment. Immunofluorescence was used show expression clock gene two mice. The results demonstrate that social leads decrease mouse activities, phase advance relatively down-regulated expression. We conclude can affect...
Colorectal carcinoma (CRC) is one of the most prevalent types malignancy-associated mortality world. Recently, studies about over-expression circadian locomotor output cycles kaput gene will promote CRC progression and inhibit tumor cell apoptosis in vitro through AKT-pathway (an antiapoptotic pathway have been reported). However, it remains to be studied molecular mechanism proliferation CRC. In our present study, we attempt study clock which inhibits CT26 cells p53-dependent when...
Circadian rhythm has been involved in the regulation of many physiological activities. Autophagy is metabolic process that transports substances cytoplasm to lysosomes for degradation, and diseases, including cancer. Studies have shown autophagy activity a circadian feature. As core gene system, clock participated occurrence development The expression whether regulates tumor by not illustrated at present. In this study, we established stable clock-knockdown strain mouse breast cancer cell...
Our previous study indicated that Clock gene could affect the thrombotic potential. In this present study, we examined differential expression of proteins in knockdown mice’s plasma, including α1-antitrypsin as a potential target. The were AML12 cells with being knocked down to confirm expressions. RNAs those extracted every 3 h 24 h. transcriptional levels (Serpina1a) and fibronectin (Fn1) analyzed least-squares fit 24-h cosine function by single cosinor method, but no circadian rhythm was...