A5100694793- Neuroinflammation and Neurodegeneration Mechanisms
- Acute Ischemic Stroke Management
- Parkinson's Disease Mechanisms and Treatments
- Cancer-related molecular mechanisms research
- COVID-19 epidemiological studies
- Tryptophan and brain disorders
- Genetic Associations and Epidemiology
- Cancer, Lipids, and Metabolism
- Gastrointestinal motility and disorders
- SARS-CoV-2 and COVID-19 Research
- Berberine and alkaloids research
- Synthesis and Biological Activity
- Advanced Computing and Algorithms
- Helicobacter pylori-related gastroenterology studies
- Nuclear Receptors and Signaling
- Gastroesophageal reflux and treatments
- COVID-19 Clinical Research Studies
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Gut microbiota and health
- PI3K/AKT/mTOR signaling in cancer
- Atherosclerosis and Cardiovascular Diseases
- Saffron Plant Research Studies
- Phytochemical and Pharmacological Studies
- Medicinal plant effects and applications
Jiangxi University of Traditional Chinese Medicine
2024-2025
University of Science and Technology of China
2023-2025
Guangzhou Institutes of Biomedicine and Health
2025
China Pharmaceutical University
2023-2024
Changchun University of Chinese Medicine
2024
Yale University
2024
State Key Laboratory of Natural Medicine
2024
Hebei Medical University
2024
Zhongshan Hospital of Xiamen University
2024
Fujian Medical University
2024
Recent evidence suggests that innate and adaptive immunity play a crucial role in Parkinson's disease (PD). However, studies regarding specific immune cell classification the peripheral blood PD remain lacking. Therefore, we aimed to explore different status patients with at ages of onset. We included 22 patients; among them were 10 who had early-onset (EOPD) 12 late-onset (LOPD) young healthy controls (YHCs) 8 elder HCs (EHCs). Mass cytometry staining technology was used perform accurate...
Metastatic castration-resistant prostate cancer (CRPC) is a currently incurable disease associated with high mortality. Novel therapeutic approaches for CRPC are urgently needed to improve prognosis. In this study, we developed cross-linked, PSMA-targeted lipoic acid nanoparticles (cPLANPs), which can interact transmembrane glycoprotein accumulate inside cells, where they upregulate caspase-3, downregulate anti-apoptotic B-cell lymphoma-2 (BCL-2), and thereby induce apoptosis. The...
The prognosis of hepatocellular carcinoma (HCC) is universally poor. Early diagnosis plays a pivotal role in determining the outcome HCC.
Background Coronary heart disease (CHD) is one of the common chronic diseases in clinical practice, often accompanied by inflammatory reactions. In recent years, system inflammation response index (SIRI) has aroused researchers’ interest as a novel biomarker. This study aims to explore relationship between SIRI and CHD through National Health Nutrition Examination Survey (NHANES) database. Methods We conducted cross-sectional analyzed participants aged 40 above with complete data from NHANES...
Bilobalide exhibits numerous beneficial bioactivities, including neuroprotective, anti-inflammatory, and antioxidant activity. Our previous study demonstrated that bilobalide inhibits adipogenesis promotes lipolysis. The dose-dependent cytotoxicity was found to be specific the mature adipocytes only, indicating potential for regulating apoptosis in them. Herein, we aimed investigate apoptotic effects of on 3T3-L1 elucidate underlying mechanisms thereof. Flow cytometry analysis (FACS)...
Ma, Lan, Ying Chen, Guoen Jin, Yingzhong Yang, Qin Ga, and Ri-Li Ge. Vascular endothelial growth factor as a prognostic parameter in subjects with "plateau red face." High Alt Med Biol 16:147-153, 2015.--Some individuals living at high altitude on the Qinghai Plateau China develop face called " Red Face" (PRF). It is characterized by telangiectasia of cheeks, which become unique ruddy color. more common young females than males, who have polycythemia are susceptible to PRF, its pathogenesis...
Background : Spearmint is commonly used as an antispasmodic and a flavouring in several medications including antacids. It can produce heartburn, presumably by lowering lower oesophageal sphincter (LES) tone, but the mechanism has not previously been objectively examined. Aim To study effect of spearmint on LES function, acid reflux symptoms. Methods In healthy volunteers, Dent Sleeve pH electrode were placed distal oesophagus. They then given either (0.5 mg), or high (500 mg) dose, placebo,...
Serum albumin (S-Alb) is a widely used biomarker of nutritional status and disease severity in patients with autoimmune diseases. We investigated the correlation between S-Alb myasthenia gravis (MG). A total number 166 subjects were recruited study. Subjects divided into 3 groups (T1 to T3) by levels: T1: 21.1 38.4 g/L, T2: 38.5 41.5 T3: 41.6 48.9 g/L. Regression analysis was performed determine initial concentrations MG. Lower levels observed increased than those slight severity, meanwhile,...
BACKGROUND Results from DNA microarray experiments have shown that the expression of miR-34s undergoes significant changes following spinal cord injury (SCI). The present study was designed to detect in and its target genes during acute sub-acute stages SCI. MATERIAL AND METHODS Luxol fast blue (LFB) staining for myelin used observe differences general morphology after SCI a contusion model rats. qPCR carried out determine variation mimic technique further confirm regulatory effect miR-34a...
Purpose: Psoriasis is a chronic, multi-system skin disease that can be influenced by immunological, environmental, and genetic factors. Plasma metabolomic analysis provide great deal of information on potential diagnostic biomarkers, pathogenesis personalized treatment. However, the role metabolites in psoriasis unknown. Patients Methods: We performed an untargeted plasma based high-resolution liquid chromatography mass spectrometry from 10 plaque patients healthy controls. Results: A total...
Background: Proton pump inhibitors (PPIs) are validated gastric acid suppressors and have been widely used to treat patients with active duodenal ulcers. Although existing PPIs shown great efficacy, many scientists still devoted developing more effective better safety profile. Herein, we aimed compare the efficacy of anaprazole in mucosal healing, a novel PPI, that rabeprazole. Methods: In this multicenter, randomized, positive-controlled, double-blinded, parallel-group phase II clinical...
Stroke is the leading cause of disability and second death worldwide. Diabetes mellitus an important independent cardiovascular risk factor in patients, regardless age, smoking habit, hypertension. Approximately one-third first-time ischemic stroke patients have diabetes. Inflammation among most pathological mechanisms atheroma formation, damage cascades acute phase, as well during subacute chronic phases after stroke. Diabetes, a common for stroke, often present long time before occurs,...
Abstract Objective To explore the predictive value of interleukin-6 (IL-6) combined with human neutrophil lipocalin (HNL) stroke-associated pneumonia (SAP) in patients who were diagnosed acute ischemic stroke (AIS). Methods 108patients divided into two groups: group (52 cases) and non-pneumonia (56 cases), according to whether developed SAP within 7 days admission. General information was compared between groups, like age, gender, history hypertension, diabetes mellitus, cardiovascular...
Natural products and their derivatives are a precious treasure in the pursuit of potent anti-inflammatory drugs. In this work, we measured toxicity 78 LA at 20 μM using MTT, then evaluated NO release compounds without obvious LPS-induced RAW.264.7 by Griess reagent, identified three compounds, namely 6, 19, 70, which exhibited promising potential. These IC
Abstract Shanghai has faced an unprecedented COVID‐19 pandemic with the BA.2.2 strain of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) Omicron infection. Comprehensive insights into its epidemiology, clinical manifestations, and viral shedding dynamics are currently limited. This study encompasses 208373 patients that were infected sub‐lineage in Shanghai, China. Demographic information, symptoms, vaccination status, isolation as well time (VST) recorded. Among included this...
Because of the shared transmission routes, co-infection with human immunodeficiency virus (HIV) and hepatitis C is very common. Accumulated clinical evidence showed that one could alter infectious course other in HIV HCV co-infected individuals. However, little known on molecular basis HIV/HCV interactions their modulations hosts. In this study, treatment-naive HIV, mono-/co-infected individuals CD4+ T cell counts >300/μl were recruited gene expression profiles investigated by microarray...
The traditional theory of bidder and regulatory agency construction engineering does not take into account the repeated periodicity game between regulator regulated party, so that mathematical point equilibrium deviates from actual behavioral expression. According to intertemporal nature agency, this paper analyzed payoff matrix subject constructed behavior model explored conditions expression (steady state unsteady state) two parties engineering. results shows that: (1) administrative...