A5009421058- Spine and Intervertebral Disc Pathology
- Prostate Cancer Diagnosis and Treatment
- Musculoskeletal pain and rehabilitation
- Urinary Bladder and Prostate Research
- Ultrasound and Hyperthermia Applications
- Hepatocellular Carcinoma Treatment and Prognosis
- Advanced MRI Techniques and Applications
- Uterine Myomas and Treatments
- Prostate Cancer Treatment and Research
- MRI in cancer diagnosis
- Management of metastatic bone disease
- Pregnancy-related medical research
- Spinal Fractures and Fixation Techniques
- Urologic and reproductive health conditions
- Endometriosis Research and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Medical Imaging and Pathology Studies
- Sarcoma Diagnosis and Treatment
- Gynecological conditions and treatments
- Advanced Radiotherapy Techniques
- Pelvic and Acetabular Injuries
- Bone Tumor Diagnosis and Treatments
- Mesenchymal stem cell research
- Advanced X-ray and CT Imaging
Turku University Hospital
2016-2025
University of Turku
2017-2025
University of Oulu
2011-2025
Oulu University Hospital
2010-2021
Physico-Technical Institute
2018
National Research University of Electronic Technology
2018
Saint Petersburg State Electrotechnical University
2018
Shandong University
2009
Harvard University Press
2006-2008
Harvard University
2005-2008
A cross-sectional magnetic resonance imaging study with questionnaires on low back pain (LBP) and functional limitations.To investigate the association between lumbar intervertebral disc degeneration (DD) symptom severity among young Finnish adults.Both LBP DD are common already in adolescence, but very little is known of their adults.Young adults belonging to a birth cohort (n=874) were invited using 1.5-T scanner. Data limitations at ages 18, 19, 21 years used cluster subjects respect...
A reliability assessment of standardized magnetic resonance imaging (MRI) interpretations and measurements.To determine the intra- inter-reader MRI features lumbar spinal stenosis (SPS), including severity central, subarticular, foraminal stenoses, grading nerve root impingement, measurements cross-sectional area canal thecal sac.MRI is commonly used to assess patients with stenosis. Although a number studies have evaluated certain characteristics, comprehensive evaluation readings in...
Obesity is a major public health problem, predisposing subjects to metabolic syndrome, type 2 diabetes, and cardiovascular diseases. Specific prolyl 4-hydroxylases (P4Hs) regulate the stability of hypoxia-inducible factor (HIF), potent governor metabolism, with isoenzyme being main regulator. We investigated whether HIF-P4H-2 inhibition could be used treat obesity its consequences. Hif-p4h-2–deficient mice, fed normal chow or high-fat diet, had less adipose tissue, smaller adipocytes, tissue...
Computed tomography (CT) and bone scintigraphy (BS) are the imaging modalities currently used for distant metastasis staging of prostate cancer (PCa).To compare standard with newer potentially more accurate modalities.This prospective, single-centre trial (NCT03537391) enrolled 80 patients newly diagnosed high-risk PCa (International Society Urological Pathology grade group ≥3 and/or prostate-specific antigen [PSA] ≥20 cT ≥ T3; March 2018-June 2019) to undergo primary two three advanced...
Purpose To evaluate whether midsagittal (abdominal) obesity in magnetic resonance imaging (MRI), waist circumference (WC) and body fat percentage are associated with lumbar disc degeneration early adulthood. Methods We obtained the MRI (1.5-T scanner) of 325 females 233 males at a mean age 21 years. Lumbar was evaluated using Pfirrmann classification. analysed associations measures (abdominal diameter (AD), sagittal (SAD), ventral subcutaneous thickness (VST), dorsal (DST)), WC sum scores...
Abstract Background Disc degeneration (DD) is a common condition that progresses with aging. Although the events leading to DD are not well understood, significant genetic influence has been found. This study was undertaken assess association between relevant candidate gene polymorphisms and moderate in well-defined characterized cohort of young adults. Focusing on age can be valuable determining predisposition DD. Methods We investigated associations existing genes for among 538 adults mean...
The aim of our study was to assess the intersubject and intrasubject variations distal tibiofibular syndesmosis on computed tomography (CT) scans define standardized measures verify reduction.A retrospective 107 CT ankles with normal syndesmosis.Main trauma center, university teaching hospital.The 64 patients were reviewed by 2 musculoskeletal radiologists.Bilateral variation estimated. intra- interobserver reliabilities calculated using measurement points. measurements included length...
In Brief Study Design. Assessment of the reliability standardized magnetic resonance imaging (MRI) interpretations and measurements. Objective. To determine intra- inter-reader MRI parameters relevant to patients with intervertebral disc herniation (IDH), including morphology classification, degree thecal sac compromise, grading nerve root impingement, measurements cross-sectional area spinal canal, sac, fragment. Summary Background Data. is increasingly used assess sciatica IDH, but...
ABSTRACT Ritonavir is the most potent and efficacious inhibitor of cytochrome P4503A (CYP3A), it used accordingly for pharmacoenhancement other antiretrovirals. Paradoxically, ritonavir induces clinical metabolism clearance many drugs. The mechanism by which inhibits drug unknown. CYP2B6 in human hepatocytes. This investigation tested hypothesis that vivo. Thirteen healthy immunodeficiency virus-negative volunteers underwent a three-way sequential crossover protocol, receiving racemic...
To prospectively compare 18F-prostate-specific membrane antigen (PSMA)-1007 positron emission tomography (PET)/CT, whole-body magnetic resonance imaging (WBMRI) including diffusion-weighted (DWI) and standard computed (CT), in primary nodal staging of prostate cancer (PCa).Men with newly diagnosed unfavourable intermediate- or high-risk PCa underwent 18F-PSMA-1007 PET/CT, WBMRI DWI contrast-enhanced CT within a median 8 days. Six readers (two for each modality) independently reported pelvic...
In Brief Study Design. A cross-sectional magnetic resonance imaging (MRI) study. Objective. We investigated the association among Modic changes, Schmorl's nodes, spondylolytic defects, high-intensity zone lesions, radial tears, herniations, and low back symptom severity. Summary of Background Data. Disc degeneration is associated with pain in early adulthood, but associations between other MRI findings are not well known. Methods. Questionnaire data scans (1.5-T) were available for 554...
Abstract Joint effusion due to elbow fractures are common among adults and children. Radiography is the most commonly used imaging procedure diagnose injuries. The purpose of study was investigate diagnostic accuracy deep convolutional neural network algorithms in joint classification pediatric adult radiographs. This retrospective consisted a total 4423 radiographs 3-year period from 2017 2020. Data randomly separated into training (n = 2672), validation 892) test set 859). Two models using...
Although it has been suggested that lumbar disc degeneration (LDD) is a significant risk factor for low back pain (LBP), its role remains uncertain. Our objective was to clarify the association between LDD and LBP whether mental distress modifies association.Participants of birth cohort underwent 1.5-T magnetic resonance imaging at age 47. The sum score (Pfirrmann classification, range 0-15) (categorized into "no pain", "mild-to-moderate "bothersome-and-frequent pain") assessed using...
The role of environmental factors in lumbar intervertebral disc degeneration (DD) young adults is largely unknown. Therefore, we investigated whether body mass index (BMI), smoking, and physical activity are associated with DD among adults. Oulu Back Study (OBS) a subpopulation the 1986 Northern Finland Birth Cohort (NFBC 1986) it originally included 2,969 children. OBS subjects received postal questionnaire, those who responded (N = 1,987) were invited to examination. participants 874) MRI...
The RFA Guardian is a comprehensive application for high-performance patient-specific simulation of radiofrequency ablation liver tumors. We address wide range usage scenarios. These include pre-interventional planning, sampling the parameter space uncertainty estimation, treatment evaluation and, in worst case, failure analysis. first its kind that exhibits sufficient performance simulating outcomes during intervention. achieve this by combining large number image processing, biomechanical...
The study aim was to utilise multiple feature selection methods in order select the most important parameters from clinical patient data for high-intensity focused ultrasound (HIFU) treatment outcome classification uterine fibroids. retrospective using 66 HIFU treatments with 89 A total of 39 features were extracted and 14 different filter-based used informative features. selected then a support vector (SVC) model evaluate performance these predicting therapy outcome. defined as non-perfused...
To assess the utility of IVIM parameters in evaluating uterine fibroid blood flow compared to dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) derived flow. Sixteen premenopausal women with fibroids were enrolled this prospective study. Pelvic MRI scans obtained for each subject, both and without continuous intravenous infusion oxytocin, known decrease significantly flow, changes fibroids. DCE analyses conducted using separate dedicated software. The bi-exponential model was...
To prospectively evaluate the feasibility, accuracy, and safety of multiparameter MRI-guided percutaneous biopsy using a 1T open MRI scanner for evaluating suspicious centrally located lung lesions with associated post-obstructive atelectasis. In this single-center study, coaxial cutting was performed 107 central atelectasis in patients between July 2015 December 2020. A fast T2-weighted imaging (T2WI)-turbo spin echo (TSE) sequence an enhanced T1-weighted (T1WI)-TSE were used to identify,...
Abstract Introduction Uterine fibroids are the most common benign tumors among women, and it is estimated that approximately 70% of women have one or multiple by age menopause. About 30% these suffer from symptoms related to fibroids. Magnetic resonance‐guided high‐intensity focused ultrasound (MR‐HIFU) a novel, non‐invasive treatment method for symptomatic uterine Material Methods In this prospective, single‐centre follow‐up study, 175 with were treated MR‐HIFU. The effect MR‐HIFU on...