A5079100857- Digital Platforms and Economics
- Open Source Software Innovations
- Innovation and Knowledge Management
- Medical Imaging Techniques and Applications
- Innovation Diffusion and Forecasting
- Business Strategy and Innovation
- Pancreatic and Hepatic Oncology Research
- Service and Product Innovation
- Radiomics and Machine Learning in Medical Imaging
- Prostate Cancer Treatment and Research
- Parathyroid Disorders and Treatments
- Neuroendocrine Tumor Research Advances
- Parkinson's Disease Mechanisms and Treatments
- Metabolism, Diabetes, and Cancer
- Radiopharmaceutical Chemistry and Applications
- Ovarian cancer diagnosis and treatment
- Medical Imaging and Pathology Studies
- Technology Adoption and User Behaviour
- Cancer, Hypoxia, and Metabolism
- Neurological disorders and treatments
- MRI in cancer diagnosis
- Digital Marketing and Social Media
- Cardiovascular Function and Risk Factors
- Adrenal and Paraganglionic Tumors
- Private Equity and Venture Capital
University of Turku
2016-2025
Turku PET Centre
2016-2025
Turku University Hospital
2016-2025
Tampere University
2015-2024
Organisation of European Cancer Institutes
2021
Tampere University
2003-2019
Tampere University of Applied Sciences
2000-2018
Zentrum für Innovation und Technik in Nordrhein-Westfalen
2013
Turku University of Applied Sciences
2012
Technical University of Munich
2012
To prospectively compare the accuracy of combined positron emission tomography/computed tomography using F-fluorodeoxyglucose (FDG-PET/CT), multidetector row computed (MDCT), and magnetic resonance imaging (MRI) in evaluation patients with suspected pancreatic malignancy.FDG-PET/CT is increasingly used for staging cancer. Preliminary data suggest a significant influence FDG-PET/CT on treatment planning, although its role still evolving.Thirty-eight consecutive suspicion malignancy were...
Purpose. Detection of bone metastases in breast and prostate cancer patients remains a major clinical challenge. The aim the current trial was to compare diagnostic accuracy 99mTc-hydroxymethane diphosphonate (99mTc-HDP) planar scintigraphy (BS), 99mTc-HDP SPECT, SPECT/CT, 18F-NaF PET/CT whole body 1.5 Tesla magnetic resonance imaging (MRI), including diffusion weighted imaging, (wbMRI+DWI) for detection high risk patients.Material methods. Twenty-six 27 at underwent BS, wbMRI+DWI. Five...
Abstract Scientific research builds on previous studies and scientifically proven knowledge. Researchers must master the recent developments in field when designing to answer new questions. Today, accessibility of literature is abundant due digitized publications, extensive coverage citation indexes, several databases. The means for conducting systematic reviews have greatly improved. In years, a lot with methods, such as reviews, mapping, visualizing studies, has been published. Despite...
Congenital hyperinsulinism of infancy (CHI) is characterized by severe hypoglycemia due to dysregulated insulin secretion, associated with either focal or diffuse pathology the endocrine pancreas. The condition caused a paternally inherited mutation in one genes encoding subunits beta-cell ATP-sensitive potassium channel (SUR1/ABCC8 Kir6.2/KCNJ11) and somatic loss maternal 11p15 alleles within affected area. Until now, preoperative diagnostics have relied on technically demanding invasive...
The aim of this study was to evaluate 2-(2-nitro-<sup>1</sup>H-imidazol-1-yl)-<i>N</i>-(2,2,3,3,3-pentafluoropropyl)-acetamide (EF5) labeled with <sup>18</sup>F-fluorine image hypoxia in patients squamous cell carcinoma the head and neck (HNSCC). <b>Methods:</b> Fifteen HNSCC were studied. Measurement tumor blood flow followed by an <sup>18</sup>F-EF5 PET/CT scan. On a separate day, <sup>18</sup>F-FDG performed determine metabolically active volume. In 6 patients, dynamic images area...
To study blood flow (BF) and metabolism in normal pancreas different pancreatic lesions. We then determined the effect of these biomarkers on outcome patients with cancer.Oxygen-15-labeled water fluorodeoxyglucose positron emission tomography/computed tomography scans were used 26 a suspicion cancer to measure BF metabolism. In addition, ratio standardized uptake value (SUV/BF) was calculated. Patients divided into three groups: finding (n = 7), benign lesions 8), malignant tumors...
Fluorine-18-L-dihydroxyphenylalanine (18F-DOPA) positron emission tomography (PET) is a promising method in localizing neuroendocrine tumors. Recently, it has been shown to differentiate focal forms of congenital hyperinsulinism infancy. The current study was set up determine the potential 18F-DOPA PET identifying insulin-secreting tumors or beta-cell hyperplasia pancreas adults.We prospectively studied 10 patients with confirmed hyperinsulinemic hypoglycemia and presumed tumor using PET....
In Brief Background: Lymphedema remains a challenging clinical problem that often lacks curative treatment options. Recent reports have shown microvascular lymph node transfer from the groin area into axillas of lymphedematous patients may improve lymphatic drainage, but effect on donor-site flow has not been studied. These be more prone to develop lymphedema at donor sites as well; therefore, authors' aim was evaluate postoperative function. Methods: The authors performed flap axilla in 13...
Patent data has been an obvious choice for analysis leading to strategic technology intelligence, yet, the recent proliferation of machine learning text methods is changing status traditional patent and approaches. This article discusses benefits constraints approaches in industry level analysis, this end offers a demonstration unsupervised based telecommunication firms between 2001 2014 on about 160,000 USPTO full-text patents. Data were classified using descriptions with Latent Dirichlet...
IntroductionThe importance of inter-organizational relationships and networks to innovation is widely acknowledged. And now, there active discussion on the topic value co-creation within boundary-spanning activities various concepts related collaborative (Lee et al., 2012). Recent studies such practices underline a variety different
Computed tomography (CT) and bone scintigraphy (BS) are the imaging modalities currently used for distant metastasis staging of prostate cancer (PCa).To compare standard with newer potentially more accurate modalities.This prospective, single-centre trial (NCT03537391) enrolled 80 patients newly diagnosed high-risk PCa (International Society Urological Pathology grade group ≥3 and/or prostate-specific antigen [PSA] ≥20 cT ≥ T3; March 2018-June 2019) to undergo primary two three advanced...
New technologies constantly change the paradigm of how businesses will be run in future. The Internet Things (IoT) enables new business opportunities for data-driven transformation organisations. emergence IoT concept has resulted numerous definitions, with earlier references primarily focussed on technological aspects. This hindered broader diffusion term as, arguably, definitions do not integrate other non-technological elements and focus more service provisions. To resolve this, our...
Accurate diagnosis of Parkinson disease (PD) remains challenging, with variability and clinical uncertainty, especially in nonspecialized settings. Despite advancements diagnostic criteria biological markers, misdiagnosis continues to affect patient care research. This study aimed assess the long-term stability PD evaluate accuracy initial diagnoses over time a large, consecutive cohort diagnosed by neurologists, or without movement disorder specialization. We conducted retrospective...
Although 6-(18)F-fluoro-L-dopa ((18)F-FDOPA) has been available to study the striatal dopaminergic system for more than 2 decades, full potential of tracer was not realized before introduction (18)F-FDOPA PET and PET/CT image a variety neuroendocrine tumors (NETs) pancreatic beta-cell hyperplasia. Together with receptor-based imaging, offers formerly unforeseen means assist in management NETs infants persistent hyperinsulinemic Institutions special expertise surgical, oncologic, radiologic...
Despite recent technological advances allowing for quantitative single-photon emission computed tomography (SPECT), SPECT has not been widely used in the clinical practice. The aim of this study is to evaluate feasibility measuring metastatic bone uptake breast and prostate cancer by comparing standard values (SUVs) measured with 99mTc-HDP SPECT/CT 18F-NaF PET/CT. Twenty-six 27 patients at high risk metastases underwent both PET/CT within 14 days each other. PET data were reconstructed using...
Understanding how the application of big data analytics (BDA) generates business value is a persistent challenge in information systems (IS) research. Improving understanding BDA realizes requires unpacking theories to study phenomenon. This unpacks task-technology fit (TTF) theory toward generating new and improved insights into BDA. Extant studies on TTF have mainly focused traditional IT which different from digital technologies like that are malleable dynamic. While has primarily...
Digital transformation compels companies to seek new strategies and business models, allowing firms find ways create capture value. APIs have been widely used in improving internal processes opened up recently third-party developers enable innovations digital ecosystems. However, few studies documented success stories of value generation through employing public thus enabling new, API-driven models. This single case study examined the one leading organizations travel industry, Amadeus...
The beginning of this millennium has become the golden age smart city initiatives, as local governments strive to exploit novel technologies improve public services and quality life their inhabitants. However, it is not enough focus only on technologies; we need understand how value identified, different parties approach that an ecosystem level. In qualitative case study, two Finnish cities were examined by employing balance framework identify proposition created what types can be captured...