A5064279763- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Cardiovascular Function and Risk Factors
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Disease and Adiposity
- Aortic aneurysm repair treatments
- Pulmonary Hypertension Research and Treatments
- Congenital Heart Disease Studies
- Atomic and Subatomic Physics Research
- Aortic Disease and Treatment Approaches
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Physical Activity and Health
- Heart Rate Variability and Autonomic Control
- Lipoproteins and Cardiovascular Health
- Cardiac Arrhythmias and Treatments
- Mobile Health and mHealth Applications
- Medical Imaging Techniques and Applications
- Coronary Interventions and Diagnostics
- Protease and Inhibitor Mechanisms
- Coronary Artery Anomalies
- Tissue Engineering and Regenerative Medicine
- Hemodynamic Monitoring and Therapy
- Cardiac Valve Diseases and Treatments
- Retinal Imaging and Analysis
- Mesenchymal stem cell research
Stanford University
2016-2025
Cardiovascular Institute of the South
2013-2025
New Zealand Christians in Science
2025
University of Portsmouth
2019-2024
Mayo Clinic
2024
Stanford Medicine
2005-2024
Cornell University
2024
Icahn School of Medicine at Mount Sinai
2024
University of California, Irvine
2024
National Heart Lung and Blood Institute
2024
Abstract Contrast agents incorporating superparamagnetic iron‐oxide nanoparticles have shown promise as a means to visualize labeled cells using MRI. Labeled cause significant signal dephasing due the magnetic field inhomogeneity induced in water molecules near cell. With resulting void for detection, particles behave negative contrast agent, which can suffer from partial‐volume effects. In this paper, new method is described imaging with positive contrast. Spectrally selective RF pulses are...
Getting enough sleep, exercising, and limiting sedentary activities can greatly contribute to disease prevention overall health longevity. Measuring the full 24-h activity cycle-sleep, behavior (SED), light-intensity physical (LPA), moderate-to-vigorous (MVPA)-may now be feasible using small wearable devices.This study compared nine devices for accuracy in a measurement.Adults (n = 40, 47% male) wore 24 h: ActiGraph GT3X+, activPAL, Fitbit One, GENEactiv, Jawbone Up, LUMOback, Nike Fuelband,...
MicroRNAs (miRs) regulate gene expression at the posttranscriptional level and play crucial roles in vascular integrity. As such, they may have a role modifying abdominal aortic aneurysm (AAA) expansion, pathophysiological mechanisms of which remain incompletely explored. Here, we investigate miRs 2 murine models experimental AAA: porcine pancreatic elastase (PPE) infusion model C57BL/6 mice AngII Apoe-/- mice. AAA development was accompanied by decreased miR-29b, along with increased known...
miR-21 modulates abdominal aortic aneurysm development by regulating cell proliferation and apoptosis within the wall.
Hip fractures are a leading cause of death and disability among older adults. also the most commonly missed diagnosis on pelvic radiographs, delayed leads to higher cost worse outcomes. Computer-aided (CAD) algorithms have shown promise for helping radiologists detect fractures, but image features underpinning their predictions notoriously difficult understand. In this study, we trained deep-learning models 17,587 radiographs classify fracture, 5 patient traits, 14 hospital process...
<h3>Importance</h3> Studies have established the importance of physical activity and fitness, yet limited data exist on associations between objective, real-world patterns, sleep, cardiovascular health. <h3>Objectives</h3> To assess feasibility obtaining measures activity, sleep from smartphones to gain insights into patterns associated with life satisfaction self-reported disease. <h3>Design, Setting, Participants</h3> The MyHeart Counts smartphone app was made available in March 2015,...
Abstract Identification and treatment of abdominal aortic aneurysm (AAA) remain among the most prominent challenges in vascular medicine. MicroRNAs (miRNAs) are crucial regulators cardiovascular pathology represent intriguing targets to limit AAA expansion. Here we show, by using two established murine models disease along with human tissue plasma analysis, that miR-24 is a key regulator inflammation pathology. In vivo vitro studies reveal chitinase 3-like 1 (Chi3l1) be major target effector...
Morbidity from undiagnosed atrial fibrillation (AF) may be preventable with early detection. Many consumer wearables contain optical photoplethysmography (PPG) sensors to measure pulse rate. PPG-based software algorithms that detect irregular heart rhythms identify AF in large populations using wearables, but minimizing false-positive detections is essential.We performed a prospective remote clinical trial examine novel algorithm for detecting range of wrist-worn devices. Adults aged ≥22...
Each decade, the American Heart Association (AHA) develops an Impact Goal to guide its overall strategic direction and investments in research, quality improvement, advocacy, public health programs. Guided by AHA's new Mission Statement, be a relentless force for world of longer, healthier lives, 2030 is anchored understanding that achieve cardiovascular all, AHA must include broader vision well-being emphasize equity. In next 2030, will strive equitably increase healthy life expectancy...
Digital technology is now an integral part of medicine. Tools for detecting, screening, diagnosis, and monitoring health-related parameters have improved patient care enabled individuals to identify issues leading better management their own health. Wearable technologies integrated sensors can measure physical activity, heart rate rhythm, glucose electrolytes. For at risk, wearables or other devices may be useful early detection atrial fibrillation sub-clinical states cardiovascular disease,...
Anomalous coronary arteries are a rare but recognized cause of myocardial ischemia and sudden death. Identification currently requires x-ray angiography, which may have difficulty defining the three-dimensional course anomalous vessel. Magnetic resonance angiography (MRCA) has been shown to image artery anatomy noninvasively. We hypothesize that MRCA be useful in identification their anatomic course.Sixteen patients (9 men, 7 women, age 44 81 years) with aortic origins by conventional...
Conventional surgery and radiotherapy for acromegaly have limitations. There are few data on the use of somatostatin analog octreotide (Oct) as primary medical therapy. An open prospective study 27 patients with newly diagnosed was conducted in nine endocrine centers United Kingdom. Twenty had macroadenomas, 7 microadenomas. For first 24 wk (phase 1), received sc Oct an initial dose 100 μg, 3 times daily, increased to 200 μg three daily after 4 13 whose mean serum GH remained greater than 5...
PURPOSE: To determine the potential benefit of prospective navigator correction image position for coronary magnetic resonance (MR) angiography. MATERIALS AND METHODS: Two-dimensional MR angiograms were obtained with free breathing in 12 adult subjects. Navigator gating was used and without windows set at 3, 5, 7 mm. compared those conventional, end-expiratory breath holding. RESULTS: resulted quality equivalent to that holding, even 7-mm window. In contrast, allowed only maintenance similar...
Comparison of respiratory suppression methods and navigator locations for MR coronary angiography.M V McConnell, C Khasgiwala, B J Savord, M H Chen, L Chuang, R Edelman W ManningAudio Available | Share
Abstract Current MR coronary angiography (MRCA) methods use breath‐holding to minimize respiratory motion. A major limitation this technique is misregistration between imaging slices due breath‐hold variability. Prospective adaptive correction of image location using real‐time navigator measurement diaphragm position a potential method for improving slice registration in MRCA. Ten subjects underwent MRCA an ECG‐gated, fat‐suppressed, segmented k‐space, gradient‐echo sequence. Transverse and...
These reporting guidelines are recommended by the Society for Cardiovascular Magnetic Resonance (SCMR) to provide a framework healthcare delivery systems disseminate cardiac and vascular imaging findings related performance of cardiovascular magnetic resonance (CMR) examinations.
A detailed longitudinal examination of plasma lipoprotein subfraction concentrations and compositions in pregnancy was performed with the objective discovering pattern change subfractions. Plasma triglyceride, cholesterol, very low density (VLDL1), (VLDL2), intermediate (IDL), (LDL) its subfractions (LDL-I, LDL-II, LDL-III), high lipoprotein-cholesterol (HDL cholesterol) were quantified 10 normal pregnant women from weeks gestation at 5 weekly intervals thereafter, until 35 gestation,...
Because of their growing popularity and functionality, smartphones are increasingly valuable potential tools for health medical research. Using ResearchKit, Apple's open-source platform to build applications ("apps") smartphone research, collaborators have developed apps researching asthma, breast cancer, cardiovascular disease, type 2 diabetes, Parkinson disease. These research enhance widespread participation by removing geographical barriers participation, provide novel ways motivate...