A5007116585- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Tissue Engineering and Regenerative Medicine
- Cardiac electrophysiology and arrhythmias
- Electrospun Nanofibers in Biomedical Applications
- Cardiac Structural Anomalies and Repair
- Cardiac Fibrosis and Remodeling
- Mesenchymal stem cell research
- Cardiac Imaging and Diagnostics
- ECG Monitoring and Analysis
- Mechanical Circulatory Support Devices
- Cardiovascular Syncope and Autonomic Disorders
- Cardiovascular Function and Risk Factors
- Non-Invasive Vital Sign Monitoring
- Pluripotent Stem Cells Research
- Peptidase Inhibition and Analysis
- Cardiac Valve Diseases and Treatments
- Heart Rate Variability and Autonomic Control
- Cardiac Ischemia and Reperfusion
- Cardiac tumors and thrombi
- Advanced MRI Techniques and Applications
- Angiogenesis and VEGF in Cancer
- Venous Thromboembolism Diagnosis and Management
- Cardiomyopathy and Myosin Studies
University of California, San Francisco
2016-2025
University of California San Francisco Medical Center
2011-2024
AtriCure (United States)
2024
Stanford Medicine
2024
Broad Center
2010-2023
California Institute for Regenerative Medicine
2012-2022
University of San Francisco
2014-2020
University of California, Berkeley
2004-2018
Cardiovascular Institute Hospital
1998-2014
Graduate Theological Union
2004-2014
Current efforts in cardiac tissue engineering center around the use of scaffolds that deliver cells to epicardial surface. In this study, we examined effects fibrin glue as an injectable scaffold and wall support ischemic myocardium. The left coronary artery rats was occluded for 17 min, followed by reperfusion. Echocardiography performed 8 days after infarction. One 2 later, either 0.5% bovine serum albumin (BSA) phosphate-buffered saline, alone, skeletal myoblasts or were injected into...
Skeletal muscle consists of parallel bundles myotubes formed by the fusion myoblasts. We fabricated nanofibrous and micropatterned polymers as cell culture substrates to guide morphogenesis muscular tissue. The nanoscale microscale topographic features regulate cytoskeleton alignment, myotube assembly, striation, myoblast proliferation. This bottom-up approach from tissue level demonstrates potential for engineering assembly structure.
Efficacy of potential treatments for myocardial infarction (MI) is commonly assessed by histological measurement infarct size in rodent models. In experiments involving an acute MI setting, the infarcted area tissue sections left ventricle a standard approach to determine size. This has also been used chronic setting measure several weeks post-MI. We tested hypothesis that, because wall thinning known occur would be less appropriate. compared measurements based on 1) area, 2) epicardial and...
Background The importance of anatomic barriers in the atrial flutter reentry circuit has been well demonstrated canine models. It shown previously that crista terminalis and its continuation as eustachian ridge form a posterior barrier. In this study we tested hypothesis tricuspid annulus forms continuous anterior barrier to circuit. Methods Results Thirteen patients with typical were studied. A 20-pole halo catheter was situated around annulus. mapping used for activation entrainment from...
Background Radiofrequency catheter ablation is the treatment of choice for patients with paroxysmal supraventricular tachycardias refractory to medical therapy. However, in symptomatic inappropriate sinus tachycardia resistant drug therapy, His’ bundle permanent pacemaker insertion currently applied. We evaluated safety and efficacy radiofrequency modification node as alternative therapy tachycardia. Methods Results Sixteen disabling episodes (4.2±0.3 trials) underwent either total or...
Novel strategies by which to repair ischemic myocardium after myocardial infarction include the use of three-dimensional polymer scaffolds. A comparative study was carried out assess therapeutic potential fibrin, collagen I, and Matrigel as injectable biopolymers for infarction. Using a rat model left coronary artery occlusion followed reperfusion, local injection into infarct zone yielded significantly higher levels capillary formation, when compared with saline control group, at 5 weeks...
AUGMENT-HF was an international, multi-centre, prospective, randomized, controlled trial to evaluate the benefits and safety of a novel method left ventricular (LV) modification with alginate-hydrogel. Alginate-hydrogel is inert permanent implant that directly injected into LV heart muscle serves as prosthetic scaffold modify shape size dilated LV. Patients advanced chronic failure (HF) were randomized (1 : 1) alginate-hydrogel (n = 40) in combination standard medical therapy or alone...
Left atrial appendage elimination may improve catheter ablation outcomes for fibrillation.
Background —Interaction between wave fronts in the right and left atrium may be important for maintenance of atrial fibrillation, but little is known about electrophysiological properties preferential routes transseptal conduction. Methods Results —Eighteen patients (age 44±12 years) without structural heart disease underwent electroanatomic mapping during pacing from distal coronary sinus (CS) or posterior atrium. During CS pacing, 9 demonstrated a single breakthrough near os, 1 patient...
Atypical Atrial Flutter. Introduction : Although the circuit in typical counterclockwise atrial flutter has been clearly delineated, mechanisms of “atypical flutters” have less well characterized. The purpose this study was to investigate ECG and electrophysiologic (EP) characteristics atypical flutter. Methods Results Thirty‐three patients with at least one form underwent EP evaluation multipolar activation entrainment mapping. Nineteen clockwise had: (1) stereotypic morphology; (2) same...
Background — Atrial fibrillation is associated with a high risk for cardioembolic stroke. The left atrial appendage (LAA) the source of vast majority these thromboemboli. A novel implanted device percutaneous LAA transcatheter occlusion (PLAATO) has been designed to seal LAA. purpose this study was test feasibility and safety in dogs. Methods Results PLAATO implant delivered through 12F transseptal catheter 25 repositioned until seen, or it recaptured replaced different size. sealing...
The purpose of our study was to define the incidence and mechanisms atypical right atrial flutter.A total 28 (8%) 372 consecutive patients with flutter (AFL) had 36 episodes sustained AFL. Among 24 (67%) lower loop reentry (LLR), 13 (54%) early breakthrough at lateral tricuspid annulus, whereas 11 (46%) high 9 (38%) showed multiple annular breaks. Bidirectional isthmus block resulted in elimination LLR. A pattern posterior from eustachian ridge septum observed 4 (14%) patients. Upper 8 (22%)...