A5057974261- Electrospun Nanofibers in Biomedical Applications
- 3D Printing in Biomedical Research
- Tissue Engineering and Regenerative Medicine
- Mesenchymal stem cell research
- Nanoplatforms for cancer theranostics
- Polymer Surface Interaction Studies
- Advanced Sensor and Energy Harvesting Materials
- Nanoparticle-Based Drug Delivery
- Silk-based biomaterials and applications
- Dyeing and Modifying Textile Fibers
- Bone Tissue Engineering Materials
- Hydrogels: synthesis, properties, applications
- Wound Healing and Treatments
- Skin Protection and Aging
- Conducting polymers and applications
- Neuroscience and Neural Engineering
- Osteoarthritis Treatment and Mechanisms
- Graphene and Nanomaterials Applications
- Nanofabrication and Lithography Techniques
- Marine Biology and Environmental Chemistry
- Gold and Silver Nanoparticles Synthesis and Applications
- Photoacoustic and Ultrasonic Imaging
- Molecular Junctions and Nanostructures
- Extracellular vesicles in disease
- Supramolecular Self-Assembly in Materials
National Taiwan University
2016-2025
Institute of Chemistry, Academia Sinica
2024
University of Technology
2023
National Taipei University of Technology
2022
National Pingtung University
2022
University of California, San Diego
2022
John Wiley & Sons (United States)
2019
Hudson Institute
2019
National Taiwan University Hospital
2017
Taipei City Government
2015
Abstract Reactive oxygen species (ROS) have been recognized as prevalent contributors to the development of inner retinal injuries including optic neuropathies such glaucoma, non‐arteritic anterior ischemic neuropathy, traumatic and Leber hereditary among others. This underscores pivotal significance oxidative stress in damage inflicted upon tissue. To combat ROS‐related challenges, this study focuses on creating an injectable tissue‐adhesive hydrogel with tailored antioxidant properties for...
Novel strategies by which to repair ischemic myocardium after myocardial infarction include the use of three-dimensional polymer scaffolds. A comparative study was carried out assess therapeutic potential fibrin, collagen I, and Matrigel as injectable biopolymers for infarction. Using a rat model left coronary artery occlusion followed reperfusion, local injection into infarct zone yielded significantly higher levels capillary formation, when compared with saline control group, at 5 weeks...
Structural similarity of electrospun fibers (ESFs) to the native extracellular matrix provides great potential for application biofunctional ESFs in tissue engineering. This study aimed synthesize biofunctionalized poly (L-lactide-co-glycolide) (PLGA) investigating cardiac engineering application. We developed a simple but novel strategy incorporate adhesive peptides PLGA ESFs. Two derived from laminin, YIGSR, and RGD, were covalently conjugated poly-L-lysine, then mingled with solution...
Photodynamic therapy (PDT) involves the cellular uptake of a photosensitizer (PS) combined with oxygen molecules and light at specific wavelength to be able trigger cancer cell death via apoptosis pathway, which is less harmful has inflammatory side effect than necrosis. However, traditional PDT treatment two main deficiencies: dark toxicity PS poor selectivity between target cells normal tissues. In this work, methylene blue (MB), known effective PS, Au nanoparticles (NPs) was prepared...
Near-infrared (NIR)-light-modulated photothermal thrombolysis has been investigated to overcome the hemorrhage danger posed by clinical clot-busting substances. A long-standing issue in thrombosis fibrinolytics is lack of lesion-specific therapy, which should not be ignored. Herein, a novel therapy using disintegration fibrin clot was explored through dual-targeting glycol chitosan/heparin-decorated polypyrrole nanoparticles (GCS-PPY-H NPs) enhance thrombus delivery and thrombolytic...
Methylene blue (MB) is a widely used dye and photodynamic therapy (PDT) agent that can produce reactive oxygen species (ROS) after light exposure, triggering apoptosis. However, it hard for the to penetrate through cell membrane, leading poor cellular uptake; thus, drug carriers, which could enhance uptake, are suitable solution. In addition, defective vessels resulting from fast vessel outgrowth leads an enhanced permeability retention (EPR) effect, gives nanoscale carriers promising...
Standardized human adipose-derived stem cell spheroids can be harvested abundantly and the differentiation capability of performed well in enzyme-crosslinked gelatin hydrogel.
Abstract The present study focuses on the utilization of a hydrogel consisting gelatin methacrylate (GelMA) and polyvinyl alcohol (PVA) as matrix for hosting redox couple Fe(CN) 6 3−/4− . exhibits discernable thermopower ( S rc ) 3 mV K −1 beneficial effect microstructure mechanical robustness is demonstrated by small‐angle X‐ray scattering (SAXS). Moreover, used to construct 3D printed thermoelectric generator (TEG) eight p‐type legs, which commendable properties, including an open‐circuit...
Abstract Reactive polymer coatings were synthesized via chemical vapor deposition (CVD) polymerization process. These decouple surface design from bulk properties of underlying materials and provide a facile general route to support thiol‐ene thiol‐yne reactions on variety substrate materials. Through the reported technique, functions can be activated through simple thiol‐terminated molecules such as polyethylene glycols (PEGs) or peptides (GRGDYC), according biological demonstrated in...
Abstract: A new microsphere consisting of inorganic mesoporous silica nanoparticles (MSNs) and organic alginate (denoted as [email protected] ) was successfully synthesized by air-dynamic atomization applied to the intracellular drug delivery systems (DDS) liver cancer cells with sustained release specific targeting properties. microspheres have advantages MSN alginate, where provides a large surface area for high loading excellent biocompatibility COOH functionality targeting. Rhodamine 6G...
Keratin, a natural biomaterial derived from wool or human hair, has the intrinsic ability to interact with different types of cells and potential serve as controllable extracellular matrix that can be used scaffold for tissue engineering. In this study, we demonstrated simple fast technique construct 3D keratin scaffolds accelerated wound healing using lyophilization method based on extraction hair. The physical properties such water uptake, pore size, porosity adjusted by changing protein...
Abstract Controlled extracellular chemical and topographical cues can generate physicochemical changes that influence the proliferation differentiation of neural cells; external electrical stimulation (ES) via conductive bioelectrodes promote by increasing neurite outgrowth. Rat pheochromocytoma (PC12) cells are used as a neuron‐like model to explore possibility using well‐designed poly(ethylene oxide) (PEO)/poly(3,4‐ethylenedioxythiophene):polystyrenesulfonate (PEDOT:PSS) blend solution...
Engineered skin that can facilitate tissue repair has been a great advance in the field of wound healing. A well-designed dressing material together with active biological cues such as cells or growth factors overcome limitation using auto-grafts from patients. Recently, many studies showed human adipose-derived stem (hASCs) be used to promote healing and engineering. hASCs have already widely applied for clinical trials. harvested abundantly because they easily isolated fat known stromal...
MXenes belong to a large family of two-dimensional layered transition-metal carbides and nitrides. MXene nanosheets integrate the fascinating advantages high electronic conductivity, excellent biocompatibility, acid/base resistance. Herein, we demonstrate "hospital-on-a-chip" system with multifunctional microneedle electrodes for biosensing electrostimulation using highly stable nanosheets. This consists integrated microchip biosensors an efficient diagnosis medical treatment elements...