A5100736974- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Neurological Disorders and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Traditional Chinese Medicine Analysis
- Anesthesia and Neurotoxicity Research
- Alzheimer's disease research and treatments
- Inflammasome and immune disorders
- Cancer-related molecular mechanisms research
- Cardiovascular Disease and Adiposity
- Immune cells in cancer
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer, Stress, Anesthesia, and Immune Response
- Adipokines, Inflammation, and Metabolic Diseases
- Mesenchymal stem cell research
- Medical Research and Treatments
- Tryptophan and brain disorders
- Acute Ischemic Stroke Management
- Gastric Cancer Management and Outcomes
- Intensive Care Unit Cognitive Disorders
- Atrial Fibrillation Management and Outcomes
- Barrier Structure and Function Studies
- Phytochemistry and Biological Activities
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- S100 Proteins and Annexins
Sun Yat-sen University
2019-2025
Guangxi University of Chinese Medicine
2025
Sixth Affiliated Hospital of Sun Yat-sen University
2025
Lianyungang Oriental Hospital
2024
Xuzhou Medical College
2011-2024
Huazhong University of Science and Technology
2020-2024
Wuhan University
2020-2024
Zhongnan Hospital of Wuhan University
2020-2024
Jilin University
2024
Chinese PLA General Hospital
2013-2024
Aside from the well-established self-renewal and multipotent differentiation properties, mesenchymal stem cells exhibit both immunomodulatory anti-inflammatory roles in several experimental autoimmune inflammatory diseases. In this study, we isolated a new population of human gingiva, tissue source easily accessible oral cavity, namely, gingiva-derived (GMSCs), which exhibited clonogenicity, self-renewal, capacities. Most importantly, GMSCs were capable functions, specifically suppressed...
Abstract Background Ischemic stroke is the second leading cause of death globally. The narrow time window for administering effective thrombolytic therapy motivates search alternative prevention strategies. Microglia and astrocyte activation-mediated inflammation play a pivotal role in ischemic injury. Cottonseed oil (CSO) has been shown to exert anti-inflammatory effects against peripheral tissue injury, although CSO mostly used as solvent lipid-soluble drugs. However, neuroprotection not...
Significance In the present study, we found a significantly up-regulated CD3 + CD4 − CD8 T cell (double-negative cell; DNT) population in peripheral blood of patients with acute stroke compared age-matched healthy subjects. Interestingly, infiltrating DNTs were mainly located close to microglia ischemic brain tissues both and middle cerebral artery occlusion mice. amplified proinflammatory subsequently enhanced neuroinflammation exacerbated injury after stroke. Mechanistically, DNT-intrinsic...
Lignans, derived from flaxseed, are phyto-oestrogens being increasingly studied for their health benefits. An 8-week, randomised, double-blind, placebo-controlled study was conducted in fifty-five hypercholesterolaemic subjects, using treatments of 0 (placebo), 300 or 600 mg/d dietary secoisolariciresinol diglucoside (SDG) flaxseed extract to determine the effect on plasma lipids and fasting glucose levels. Significant treatment effects were achieved ( P < 0·05 0·001) decrease total...
Abstract Background Silicosis is one of the most common occupational pulmonary fibrosis caused by respirable silica-based particle exposure, with no ideal drugs at present. Metformin, a commonly used biguanide antidiabetic agent, could activate AMP-activated protein kinase (AMPK) to exert its pharmacological action. Therefore, we sought investigate role metformin in silica-induced lung fibrosis. Methods The anti-fibrotic was assessed 50 mg/kg model. Silicon dioxide (SiO 2 )-stimulated...
Background: Alzheimer's disease (AD) is a neurodegenerative characterized by loss of recognition and memory. Neuroinflammation plays pivotal roles in the pathology AD affects progression disease. Astrocyte microglia, as main immune executors central nervous system (CNS), participate into inflammatory response AD. Glia polarize different phenotypes during neurodegeneration. Pro-inflammatory glia produce cytokines (IL-1β, TNF-α, IL-6) resulting debris aggregates neurotoxicity....
Alzheimer's disease (AD) and related Tauopathies are characterised by the pathologically hyperphosphorylated aggregated microtubule-associated protein Tau, which is accompanied neuroinflammation mediated activated microglia. However, role of Tau pathology in microglia activation or their causal relationship remains largely elusive.
In order to investigate the role of interleukin-5 (IL-5) in airway hyperreactivity and eosinophilia, we observed effect inhaled recombinant human IL-5 on responsiveness methacholine cell populations induced sputum eight patients with allergic bronchial asthma using a placebo-controlled study design. Our results demonstrated that inhalation did not alter lung function asthmatics. control experiments receiving either vehicle or 0.4 ng endotoxin, PC20 values change nor numbers eosinophils...
Background Nonalcoholic fatty liver disease (NAFLD) is considered to be associated with diet and gut dysbiosis. Excessive sucralose can induce dysbiosis negatively affect host health. Maternal shapes the microbial communities of neonate this effect continues in later life. We aimed investigate effects maternal (MS) intake on susceptibility offspring hepatic steatosis adulthood.Methods C57BL/6 pregnant mice were randomized into MS group (MS during gestation lactation) control (MC) (MC diet)....
Sepsis-associated encephalopathy (SAE) is a poorly understood condition that leads to long-term cognitive impairment and increased mortality in survivors. Recent research revealed IL-17A/IL-17R might serve as checkpoint microglia-mediated neuroinflammation. The present study was designed determine the specific role of IL-17A-mediated microglia activation development SAE. A mouse model SAE induced by cecal ligation puncture (CLP), behavior performance evaluated inhibitory avoidance test open...
The immunological responses are a key pathological factor in Alzheimer's disease (AD).We hypothesized that microglial polarization alters microglia-astrocyte immune interactions AD.M1 and M2 microglia were isolated from primary rat confirmed to secrete pro-inflammatory anti-inflammatory factors, respectively.Primary astrocytes co-cultured with M1 or medium.M1 medium increased astrocyte production of factors (interleukin [IL]-1β, tumor necrosis α IL-6), while enhanced (IL-4 IL-10).To analyze...
Scope Oxidative stress is involved in chronic stress‐induced depression and the disruption of neurotransmission neuroplasticity. Recently, orientin, a phenolic compound abundant some fruits, millet, herbs, has been shown to have antioxidant properties. This study investigated potential antidepressant effects orientin against its underlying mechanisms. Methods results The unpredictable mild (CUMS) model was used investigate on behavior biochemical alterations mice. After 2 weeks CUMS...
Many studies have shown that microglia in the activated state may be neurotoxic. It has been proven uncontrolled or over-activated play an important role many neurodegenerative disorders. Bone marrow-derived mesenchymal stem cells (BMSCs) animal models to a therapeutic effect on neural damage. Such is attributed fact BMSCs ability differentiate into neurons and produce trophic factors, but there little information available literature concerning whether by affecting microglial activity. In...
The inflammatory response plays a pivotal role in blood-brain barrier (BBB) destruction following ischemic brain injury. Enhanced leukocyte adhesion to vascular endothelial cells is an essential event the process. TMEM16A, newly discovered protein regulating calcium-activated chloride channels, widely expressed eukaryotes. Recent studies have suggested that upregulated expression of TMEM16A associated with occurrence and development many diseases. However, BBB integrity after stroke has not...
L‐theanine (γ‐glutamylethylamide), an amino acid component of green tea, has been shown to reduce mental and physical stress, improve memory function. In this study, the antidepressant effect was investigated in mice using forced swim test, tail suspension open‐field test reserpine test. produced antidepressant‐like effect, since administration at doses 1, 4 20 mg/kg for 10 successive days significantly reduced immobility time both compared with control group, without accompanying changes...