A5043867999- Aortic Disease and Treatment Approaches
- Aortic aneurysm repair treatments
- Radiomics and Machine Learning in Medical Imaging
- Cardiac Valve Diseases and Treatments
- Renal and Vascular Pathologies
- Acute Myeloid Leukemia Research
- Systemic Lupus Erythematosus Research
- Head and Neck Cancer Studies
- Infectious Aortic and Vascular Conditions
- Congenital Heart Disease Studies
- Cancer-related molecular mechanisms research
- Cardiovascular and Diving-Related Complications
- MRI in cancer diagnosis
- Multiple Myeloma Research and Treatments
- MicroRNA in disease regulation
- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cardiac, Anesthesia and Surgical Outcomes
- Pancreatic and Hepatic Oncology Research
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Circular RNAs in diseases
- Vascular Procedures and Complications
- Atherosclerosis and Cardiovascular Diseases
Second Affiliated Hospital of Guangzhou Medical University
2010-2025
Guangzhou Medical University
2010-2025
Guangdong Academy of Medical Sciences
2011-2024
Guangdong Provincial People's Hospital
2007-2024
China Communications Construction Company (China)
2024
Southern Medical University
2013-2024
Guangdong Ocean University
2024
First Affiliated Hospital of Jinan University
2024
Shandong Normal University
2024
Gansu Provincial Hospital
2024
Purpose: To identify MRI-based radiomics as prognostic factors in patients with advanced nasopharyngeal carcinoma (NPC).Experimental Design: One-hundred and eighteen (training cohort: n = 88; validation 30) NPC were enrolled. A total of 970 features extracted from T2-weighted (T2-w) contrast-enhanced T1-weighted (CET1-w) MRI. Least absolute shrinkage selection operator (LASSO) regression was applied to select for progression-free survival (PFS) nomograms. Nomogram discrimination calibration...
ABSTRACT Carbapenem-resistant Enterobacteriaceae (CRE) infection is highly endemic in China, but estimates of the burden are lacking. We established incidence CRE from a multicenter study that covered 25 tertiary hospitals 14 provinces. cases defined as carbapenem-nonsusceptible Citrobacter freundii , Escherichia coli Enterobacter cloacae or Klebsiella pneumoniae infections during January to December 2015 were collected and reviewed medical records. Antimicrobial susceptibility testing...
Abstract Background Coping strategies are a potential way to improve interventions designed manage the caregiver burden of dementia. The purpose this study was develop an intervention targeted towards improving coping and examine its effectiveness on reducing burden. Methods A controlled design used. Fifty‐seven caregivers dementia patients were enrolled. assessed with R evised W ays C oping hecklist ( WCCL‐R ) hinese version aregiver B urden I nventory. participants randomly divided into...
We report the development and optimization of reagents for in-solution, hybridization-based capture mouse exome. By validating this approach in a multiple inbred strains novel mutant strains, we show that whole exome sequencing is robust discovery putative mutations, irrespective strain background. found strong candidate mutations majority exomes sequenced, including new models orofacial clefting, urogenital dysmorphology, kyphosis autoimmune hepatitis.
We aimed to identify a magnetic resonance imaging (MRI)-based model for assessment of the risk individual distant metastasis (DM) before initial treatment nasopharyngeal carcinoma (NPC).This retrospective cohort analysis included 176 patients with NPC. Using PyRadiomics platform, we extracted features primary tumors in all who did not exhibit DM treatment. Subsequently, used minimum redundancy-maximum relevance and least absolute shrinkage selection operator algorithms select strongest build...
We aimed to investigate the potential of radiomic features magnetic resonance imaging (MRI) predict progression in patients with advanced nasopharyngeal carcinoma (NPC). One hundred and thirteen consecutive (01/2007-07/2013) (training cohort: n = 80; validation 33) NPC were enrolled. A total 970 initial extracted from T2-weighted (T2-w) (n 485) contrast-enhanced T1-weighted (CET1-w) MRI for each patient. used least absolute shrinkage selection operator (Lasso) method select that most...
Objective To investigate the efficacy and safety of telitacicept treatment in a Chinese SLE cohort, with real-life settings. Methods All patients who were receiving at least 4 weeks included, followed up. Patients received subcutaneous injection weekly based on standard treatment. responder index-4 (SRI-4) was assessed before first administration after administration. Disease flares during follow-up period defined as an increase disease activity number or dose immunosuppressive drugs....
Abdominal aortic aneurysms (AAAs) can result in high mortality upon rupture but are usually undiagnosed because of the absence symptoms early stage. Ultrasound screening is regarded as an impactful way to prevent AAA-related death cannot be performed efficiently; therefore, a target population, especially Asia, for this procedure lacking. Additionally, although dyslipidaemia and atherosclerosis associated with AAA. However, it remains undetermined whether non-high-density...
Atrioventricular septal defects (AVSDs) are a common severe form of congenital heart disease (CHD). In this study we identified deleterious non-synonymous mutations in two cilia genes, Dnah11 and Mks1, independent N-ethyl-N-nitrosourea-induced mouse mutant lines with heritable recessive AVSDs by whole-exome sequencing. Cilia required for left/right body axis determination second field (SHF) Hedgehog (Hh) signaling, find that affect these requirements differentially. Dnah11avc4 did not...
Background: To develop and validate a radiomic nomogram incorporating features with clinical variables for individual local recurrence risk assessment in nasopharyngeal carcinoma (NPC) patients before initial treatment. Methods: One hundred forty were randomly divided into training cohort (n = 80) validation 60). A total of 970 extracted from pretreatment magnetic resonance (MR) images NPC May 2007 to December 2013. Univariate multivariate analyses used selecting associated recurrence, was...
Background: Multiple myeloma (MM) is the second most common hematologic malignancy worldwide and does not have sufficient prognostic indicators.FCER1G (Fc fragment Of IgE receptor Ig) located on chromosome 1q23.3and involved in innate immunity.Early studies shown that FCER1G participates many immune-related pathways encompassing multiple cell types.Meanwhile, it associated with malignancies.However, relationship between MM has been studied.Methods: In this study, we integrated nine...
There is no consensus on specific prognostic biomarkers potentially improving survival of nasopharyngeal carcinoma (NPC), especially in advanced-stage disease. The value MRI-based radiomics signature unclear. A total 970 quantitative features were extracted from the tumor 100 untreated NPC patients (stage III-IVb) (discovery set: n = 70, validation 30). We then applied least absolute shrinkage and selection operator (lasso) regression to select that most associated with progression-free...
Abstract The mammalian target of rapamycin (mTOR) inhibitor, DNA damage inducible transcript 4 (DDIT4), has expression in response to various cellular stresses. In multiple malignancies, studies have shown that DDIT4 participates tumorigenesis and impacts patient survival. We aimed study the prognostic value acute myeloid leukaemia (AML), which is currently unclear. Firstly, Cancer Genome Atlas was screened for AML patients with complete clinical characteristics data. A total 155 were...
Lupus nephritis (LN) frequently manifests as a significant complication in systemic lupus erythematosus (SLE) patients, with emerging research indicating plausible correlation between subclinical retinal involvement and renal manifestations. This study aims to investigate the relationship neutrophil-to-C3 ratio (NC3R) both LN well microvasculature damage among SLE patients. In this cross-sectional study, cohort of 220 participants (78 142 non-LN) was recruited. We assessed clinical...
Spinal cord ischemia (SCI) is a recognized grave complication after thoracic endovascular aortic repair (TEVAR). The present study aimed to evaluate the incidence and investigate risk of SCI TEVAR based on current prophylactic strategies designed against established factors.The retrospectively reviewed prospectively maintained database patients who underwent successfully between January 2009 December 2012 in single cardiovascular center. Detailed assessment was routinely performed for all...