Carol J. Bult
A5028990206- Radiomics and Machine Learning in Medical Imaging
- Cancer Genomics and Diagnostics
- AI in cancer detection
- Bioinformatics and Genomic Networks
- Biomedical Text Mining and Ontologies
- Cancer Research and Treatments
- RNA modifications and cancer
- Gene expression and cancer classification
- Genomics and Phylogenetic Studies
- Epigenetics and DNA Methylation
- Computational Drug Discovery Methods
- Genetics, Bioinformatics, and Biomedical Research
- Genomics and Rare Diseases
- HER2/EGFR in Cancer Research
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- RNA and protein synthesis mechanisms
- Genetic Mapping and Diversity in Plants and Animals
- Lung Cancer Treatments and Mutations
- Molecular Biology Techniques and Applications
- Single-cell and spatial transcriptomics
- Genomics and Chromatin Dynamics
- Cell Image Analysis Techniques
- CRISPR and Genetic Engineering
- Cancer Immunotherapy and Biomarkers
Jackson Laboratory
2016-2025
Genetic Alliance
2023
Digital Research Alliance of Canada
2023
University of Maine
1998-2022
The Graduate Center, CUNY
2021-2022
The JAX Cancer Center
2017
Duke University
2013
Georgetown University
2013
Georgetown University Medical Center
2013
University of Delaware
2013
An approach for genome analysis based on sequencing and assembly of unselected pieces DNA from the whole chromosome has been applied to obtain complete nucleotide sequence (1,830,137 base pairs) bacterium Haemophilus influenzae Rd. This eliminates need initial mapping efforts is therefore applicable vast array microbial species which maps are unavailable. The H. Rd (Genome Sequence DataBase accession number L42023) represents only a free-living organism.
The Gene Ontology (GO) project (http://www. geneontology.org/) provides structured, controlled vocabularies and classifications that cover several domains of molecular cellular biology are freely available for community use in the annotation genes, gene products sequences. Many model organism databases genome groups GO contribute their sets to resource. database integrates contributed annotations full access this information formats. Members Consortium continually work collectively,...
The complete nucleotide sequence (580,070 base pairs) of the Mycoplasma genitalium genome, smallest known genome any free-living organism, has been determined by whole-genome random sequencing and assembly. A total only 470 predicted coding regions were identified that include genes required for DNA replication, transcription translation, repair, cellular transport, energy metabolism. Comparison this to Haemophilus influenzae suggests differences in content are reflected as profound...
The complete 1.66-megabase pair genome sequence of an autotrophic archaeon, Methanococcus jannaschii, and its 58- 16-kilobase extrachromosomal elements have been determined by whole-genome random sequencing. A total 1738 predicted protein-coding genes were identified; however, only a minority these (38 percent) could be assigned putative cellular role with high confidence. Although the majority related to energy production, cell division, metabolism in M. jannaschii are most similar those...
Only a small proportion of the mouse genome is transcribed into mature messenger RNA transcripts. There an international collaborative effort to identify all full-length mRNA transcripts from mouse, and ensure that each represented in physical collection clones. Here we report manual annotation 60,770 complementary DNA sequences. These are clustered 33,409 'transcriptional units', contributing 90.1% newly established transcriptome database. Of these transcriptional units, 4,258 new...
The Mouse Genome Database (MGD; http://www.informatics.jax.org) is the community model organism genetic and genome resource for laboratory mouse. MGD authoritative source biological reference data sets related to mouse genes, gene functions, phenotypes, models of human disease. primary outlet official gene, allele strain nomenclature based on guidelines set by International Committee Standardized Nomenclature Mice. In this report we describe significant enhancements MGD, including two new...
A finished clone-based assembly of the mouse genome reveals extensive recent sequence duplication during evolution and rodent-specific expansion certain gene families. Newly assembled duplications contain protein-coding genes that are mostly involved in reproductive function.
The Mouse Genome Database, (MGD, http://www.informatics.jax.org /), integrates genetic, genomic and phenotypic information about the laboratory mouse, a primary animal model for studying human biology disease. MGD data content includes comprehensive characterization of genes their functions, standardized descriptions mouse phenotypes, extensive integration DNA protein sequence data, normalized representation genome variant including comparative on mammalian genes. Data within are obtained...
To better characterize aging in mice, the Jackson Aging Center carried out a lifespan study of 31 genetically-diverse inbred mouse strains housed specific pathogen-free facility. Clinical assessments were every 6 months, measuring multiple age-related phenotypes including neuromuscular, kidney and heart function, body composition, bone density, hematology, hormonal levels, immune system parameters. In concurrent cross-sectional same at 6, 12, 20 more invasive measurements followed by...
Abstract- The skewness criterion of phylogenetic structure in data is too sensitive to character state frequencies, not enough number characters (degree corroboration) and relies on counts arbitrarily-resolved bifurcating trees. For these reasons it can give misleading results. Permutation tests lack those drawbacks be performed quickly by using approximate parsimony calculations, but the test based minimal tree length imply strong ambiguous data. A more satisfactory obtained a support...
The Mouse Genome Database (MGD, http://www.informatics.jax.org) serves the international biomedical research community as central resource for integrated genomic, genetic and biological data on laboratory mouse. To facilitate use of mouse a model in translational studies, MGD maintains core high-quality curated integrates experimentally computationally generated sets. unified catalog genes genome features, including functional RNAs, QTL phenotypic loci. curates provides phenotype annotations...
The Mouse Genome Database (MGD; http://www.informatics.jax.org) is the community model organism knowledgebase for laboratory mouse, a widely used animal comparative studies of genetic and genomic basis human health disease. MGD authoritative source biological reference data related to mouse genes, gene functions, phenotypes models primary official gene, allele, strain nomenclature based on guidelines set by International Committee Standardized Nomenclature Mice. MGD's biocuration scientists...
In 2007, the International Knockout Mouse Consortium (IKMC) made ambitious promise to generate mutations in virtually every protein-coding gene of mouse genome a concerted worldwide action. Now, 5 years later, IKMC members have developed high-throughput trapping and, particular, gene-targeting pipelines and generated more than 17,400 mutant murine embryonic stem (ES) cell clones 1,700 strains, most them conditional. A common web portal (www.knockoutmouse.org) has been established, allowing...
The Mouse Genome Database (MGD: http://www.informatics.jax.org) is the primary community data resource for laboratory mouse. It provides a highly integrated and curated system offering comprehensive view of current knowledge about mouse genes, genetic markers genomic features as well associations those with sequence, phenotypes, functional comparative information, their relationships to human diseases. MGD continues enhance access these data, extend scope content visualizations, provide...
The Mouse Genome Database (MGD) is the community model organism database for laboratory mouse and authoritative source phenotype functional annotations of genes. MGD includes a complete catalog genes genome features with integrated access to genetic, genomic phenotypic information, all serving further use as system studying human biology disease. major component Informatics (MGI, http://www.informatics.jax.org/) resource. contains standardized descriptions phenotypes, associations between...
RNAcentral is a comprehensive database of non-coding RNA (ncRNA) sequences, collating information on ncRNA sequences all types from broad range organisms. We have recently added new genome mapping pipeline that identifies genomic locations for in 296 species. also several functional annotations, such as tRNA secondary structures, Gene Ontology and miRNA-target interactions. A quality control mechanism based Rfam family assignments potential contamination, incomplete more. The has become...
The Mouse Genome Database (MGD, http://www.informatics.jax.org) is the international community resource for integrated genetic, genomic and biological data about laboratory mouse. Data in MGD are obtained through loads from major providers experimental consortia, electronic submissions laboratories biomedical literature. maintains a comprehensive, unified, non-redundant catalog of mouse genome features generated by distilling gene predictions NCBI, Ensembl VEGA. serves as authoritative...
The Mouse Genome Database (MGD; http://www.informatics.jax.org) is the key community mouse database which supports basic, translational and computational research by providing integrated data on genetics, genomics, biology of laboratory mouse. MGD serves as source for biological reference sets related to genes, gene functions, phenotypes disease models with an increasing emphasis association these human disease. We report here recent enhancements this resource, including improved access...
The Mouse Genome Database (MGD) (http://www.informatics.jax.org) is the community model organism database resource for laboratory mouse, a premier animal study of genetic and genomic systems relevant to human biology disease. MGD maintains comprehensive catalog genes, functional RNAs other genome features as well heritable phenotypes quantitative trait loci. feature generated by integration computational manual annotations NCBI, Ensembl Vega/HAVANA. curates listing mouse genes using Gene...
The Mouse Phenome Database (MPD; http://www.jax.org/phenome) is an open source, web-based repository of phenotypic and genotypic data on commonly used genetically diverse inbred strains mice their derivatives. MPD also a facility for query, analysis in silico hypothesis testing. Currently contains about 1400 measurements contributed by research teams worldwide, including phenotypes relevant to human health such as cancer susceptibility, aging, obesity, susceptibility infectious diseases,...