A5100731835- Health Systems, Economic Evaluations, Quality of Life
- Antiplatelet Therapy and Cardiovascular Diseases
- Pharmaceutical Practices and Patient Outcomes
- Atrial Fibrillation Management and Outcomes
- Lipoproteins and Cardiovascular Health
- Bone health and treatments
- Blood Pressure and Hypertension Studies
- Pharmaceutical Economics and Policy
- Medication Adherence and Compliance
- Dermatology and Skin Diseases
- Acute Myocardial Infarction Research
- Pneumonia and Respiratory Infections
- Phagocytosis and Immune Regulation
- Stroke Rehabilitation and Recovery
- Proteoglycans and glycosaminoglycans research
- Cardiac, Anesthesia and Surgical Outcomes
- Coronary Interventions and Diagnostics
- Allergic Rhinitis and Sensitization
- Helicobacter pylori-related gastroenterology studies
- Immune cells in cancer
- Systemic Lupus Erythematosus Research
- Meteorological Phenomena and Simulations
- Climate variability and models
- Ocular Oncology and Treatments
- Acute Ischemic Stroke Management
Chinese University of Hong Kong
2016-2025
National University of Singapore
2025
Massey University
2025
Harvard University
1977-2024
University of Hong Kong
2011-2024
Environment and Climate Change Canada
2010-2024
University of California, Los Angeles
2019-2024
Hospital of the University of Pennsylvania
2024
University of Pennsylvania
2013-2023
Penn Presbyterian Medical Center
2014-2023
The Gene Ontology (GO) project (http://www. geneontology.org/) provides structured, controlled vocabularies and classifications that cover several domains of molecular cellular biology are freely available for community use in the annotation genes, gene products sequences. Many model organism databases genome groups GO contribute their sets to resource. database integrates contributed annotations full access this information formats. Members Consortium continually work collectively,...
Concurrent therapy with a proton-pump inhibitor is standard treatment for patients receiving aspirin who are at risk ulcer. Current U.S. guidelines also recommend clopidrogel have major gastrointestinal intolerance of aspirin. We compared clopidogrel plus esomeprazole the prevention recurrent bleeding from ulcers in high-risk patients.We studied took to prevent vascular diseases and presented ulcer bleeding. After had healed, we randomly assigned were negative Helicobacter pylori receive...
A neutral gastric pH is critical for the stability of clots over bleeding arteries. We investigated effect preemptive infusion omeprazole before endoscopy on need endoscopic therapy.
Purpose: The ubiquitously expressed transmembrane glycoprotein CD47 delivers an anti-phagocytic (do not eat) signal by binding signal-regulatory protein α (SIRPα) on macrophages. is overexpressed in cancer cells and its expression associated with poor clinical outcomes. TTI-621 (SIRPαFc) a fully human recombinant fusion that blocks the CD47-SIRPα axis to enhancing phagocytosis of malignant cells. Blockade this inhibitory using has emerged as promising therapeutic strategy promote tumor cell...
Abstract The Global Environmental Multiscale (GEM) model is the Canadian atmospheric used for meteorological forecasting at all scales. A limited-area version now also exists. It a gridpoint with an implicit semi-Lagrangian iterative space–time integration scheme. In “horizontal,” equations are written in spherical coordinates traditional shallow atmosphere approximations and discretized on Arakawa C grid. “vertical,” were originally defined using hydrostatic-pressure coordinate regular...
The paper presents the most comprehensive and large-scale global study to date on how higher education students perceived use of ChatGPT in early 2024. With a sample 23,218 from 109 countries territories, reveals that primarily used for brainstorming, summarizing texts, finding research articles, with few using it professional creative writing. They found useful simplifying complex information content, but less reliable providing supporting classroom learning, though some considered its...
Abstract Background The Gene Ontology Annotation (GOA) database http://www.ebi.ac.uk/GOA aims to provide high-quality supplementary GO annotation proteins in the UniProt Knowledgebase. Like many other biological databases, GOA gathers much of its content from careful manual curation literature. However, as both volume literature and requiring characterization increases, processing capability can become overloaded. Consequently, semi-automated aids are often employed expedite process....
The ATP-binding cassette G2 (ABCG2) c.421C>A (rs2231142) polymorphism influences the pharmacokinetics of rosuvastatin. We examined whether this low-density lipoprotein cholesterol (LDL-C)-lowering efficacy drug. In 305 Chinese patients with hypercholesterolemia who were treated rosuvastatin at a dosage 10 mg daily, c.421A variant was found to be significantly associated greater reduction in LDL-C level, gene-dose-dependent manner. As compared subjects c.421CC genotype, those c.421AA genotype...
Mild cognitive impairment (MCI) patients are at risk of decline, while elevated serum homocysteine is also associated with impairment. Thus, older people MCI and hyperhomocysteinemia may be under greater decline. We therefore performed a randomized trial homocysteine-lowering by B vitamins supplementation to prevent decline in homocysteine.279 outpatients aged ≥65 years ≥10.0 μmol/L were randomly assigned take either methylcobalamin 500 μg folic acid 400 once daily, or two placebo tablets...
Versican is a large chondroitin sulfate proteoglycan belonging to the lectican family. Alternative splicing of versican generates at least four isoforms named V0, V1, V2, and V3. We have shown that V1 isoform not only enhanced cell proliferation, but also modulated cycle progression protected cells from apoptosis. Futhermore, was able activate proto-oncogene EGFR expression modulate its downstream signaling pathway, induce p27 degradation enhance CDK2 kinase activity. As well, down-regulated...
To evaluate both direct and indirect costs of systemic lupus erythematosus (SLE) patients with without flares from a societal perspective, to investigate the impact severity clinical manifestations on direct/indirect costs.A retrospective cost-of-illness study was performed 306 SLE patients. Participants completed questionnaires sociodemographics, employment status, out-of-pocket expenses. Health resources consumption recorded by chart review patient self-reported questionnaire. The total...
Abstract At the Canadian Meteorological Center (CMC), we are currently developing future global forecasting Yin‐Yang model. In horizontal use spherical coordinates on overset grid, while in vertical a log‐hydrostatic‐pressure coordinate Charney–Phillips grid. The parametrization of physical processes is kept same as current Global Environmental Multiscale (GEM) operational forecast performed by considering domain decomposition (a two‐way coupling method) between two limited‐area models...
Background: Staphylococcus aureus (S. aureus) colonization/infection is an important factor in the pathophysiology of atopic dermatitis (AD). Clinical trials have demonstrated conflicting efficacy diluted bleach baths treating moderate-to-severe AD. We conducted a double-blinded, placebo-controlled (water), cross-over trial among patients with AD to investigate reducing S. colonization and severity. Method: In this trial, 40 were randomized receive twice-weekly water baths, each for four...