A5009147827- Metabolomics and Mass Spectrometry Studies
- Bioinformatics and Genomic Networks
- RNA and protein synthesis mechanisms
- Fungal and yeast genetics research
- Microbial Metabolic Engineering and Bioproduction
- Biomedical Text Mining and Ontologies
- Mitochondrial Function and Pathology
- RNA Research and Splicing
- Microbial Natural Products and Biosynthesis
- Antifungal resistance and susceptibility
- Cervical Cancer and HPV Research
- Genomics and Phylogenetic Studies
- RNA modifications and cancer
- Fermentation and Sensory Analysis
- Genetic Associations and Epidemiology
- Bacterial Genetics and Biotechnology
- Bacteriophages and microbial interactions
- Photosynthetic Processes and Mechanisms
- Probiotics and Fermented Foods
- Gene expression and cancer classification
- Genetics, Bioinformatics, and Biomedical Research
- Pharmaceutical Economics and Policy
- Genital Health and Disease
- Health Systems, Economic Evaluations, Quality of Life
- Congenital heart defects research
Broad Institute
2018-2025
University of Catania
2013-2023
Oasi Maria SS
2020-2021
Istituti di Ricovero e Cura a Carattere Scientifico
2020-2021
Fondazione Humanitas per la Ricerca
2020
Angiologica (Italy)
2020
Massachusetts General Hospital
2018
McMaster University
2018
American Heart Association
2018
Yale University
2018
The Gene Ontology (GO) project (http://www. geneontology.org/) provides structured, controlled vocabularies and classifications that cover several domains of molecular cellular biology are freely available for community use in the annotation genes, gene products sequences. Many model organism databases genome groups GO contribute their sets to resource. database integrates contributed annotations full access this information formats. Members Consortium continually work collectively,...
The Saccharomyces Genome Database (SGD, http://www.yeastgenome.org) is the community resource for budding yeast cerevisiae. SGD project provides highest-quality manually curated information from peer-reviewed literature. experimental results reported in literature are extracted and integrated within a well-developed database. These data combined with quality high-throughput provided through Locus Summary pages, powerful query engine rich genome browser. acquisition, integration retrieval of...
Candida species are the most common cause of opportunistic fungal infection worldwide. Here we report genome sequences six and compare these related pathogens non-pathogens. There significant expansions cell wall, secreted transporter gene families in pathogenic species, suggesting adaptations associated with virulence. Large genomic tracts homozygous three diploid possibly resulting from recent recombination events. Surprisingly, key components mating meiosis pathways missing several...
The genome of the budding yeast Saccharomyces cerevisiae was first completely sequenced from a eukaryote. It released in 1996 as work worldwide effort hundreds researchers. In time since, has been intensively studied by geneticists, molecular biologists, and computational scientists all over world. Maintenance annotation sequence have long provided Genome Database, one original model organism databases. To deepen our understanding eukaryotic genome, S. strain S288C reference updated recently...
Recent sequencing and assembly of the genome for fungal pathogen Candida albicans used simple automated procedures identification putative genes. We have reviewed entire assembly, both by hand with additional bioinformatic resources, to accurately map describe 6,354 genes identify 246 whose original database entries contained errors (or possibly mutations) that affect their reading frame. Comparison other genomes permitted numerous fungus-specific might be targeted antifungal therapy. also...
Associations between human genetic variation and clinical phenotypes have become a foundation of biomedical research. Most repositories these data seek to be disease-agnostic therefore lack disease-focused views. The Type 2 Diabetes Knowledge Portal (T2DKP) is public resource datasets genomic annotations dedicated type diabetes (T2D) related traits. Here, we make the T2DKP more accessible prospective users useful existing users. First, evaluate T2DKP's comprehensiveness by comparing its with...
The BioKnowledge Library is a relational database and web site (http://www.proteome.com) composed of protein-specific information collected from the scientific literature. Each Protein Report on summarizes displays published about single protein, including its biochemical function, role in cell whole organism, localization, mutant phenotype genetic interactions, regulation, domains motifs, interactions with other proteins relevant data. This report describes four species-specific volumes...
The Yeast Proteome Database (YPD™) has been for several years a resource organized and accessible information about the proteins of Saccharomycescerevisiae. We have now extended YPD format to create database containing complete proteome model organism Caenorhabditiselegans (WormPD™). WormPD are designed use not only by their respective research communities but also broader scientific community. In both databases, gleaned from literature is presented in consistent, user-friendly Protein...
The Saccharomyces Genome Database (SGD; http://www.yeastgenome.org/) collects and organizes biological information about the chromosomal features gene products of budding yeast cerevisiae. Although published data from traditional experimental methods are primary sources evidence supporting Gene Ontology (GO) annotations for a product, high-throughput experiments computational predictions can also provide valuable insights in absence an extensive body literature. Therefore, GO available at...
The IntAct molecular interaction database has created a new, free, open-source, manually curated resource, the Complex Portal (www.ebi.ac.uk/intact/ complex), through which protein complexes from major model organisms are being collated and made available for search, viewing download.It been built in close collaboration with other bioinformatics services populated data ChEMBL, MatrixDB, PDBe, Reactome UniPro-tKB.Each entry contains information about participating molecules (including small...
Lipid droplets (LDs) are organelles of cellular lipid storage with fundamental roles in energy metabolism and cell membrane homeostasis. There has been an explosion research into the biology LDs, part due to their relevance diseases storage, such as atherosclerosis, obesity, type 2 diabetes, hepatic steatosis. Consequently, there is increasing need for a resource that combines datasets from systematic analyses LD biology. Here, we integrate high-confidence, systematically generated human,...
The human retina is a multilayered tissue that offers unique window into systemic health. Optical coherence tomography (OCT) widely used in eye care and allows the noninvasive, rapid capture of retinal anatomy exquisite detail. We conducted genotypic phenotypic analyses layer thicknesses using macular OCT images from 44,823 UK Biobank participants. performed cross-phenotype association (OCT-XWAS), associating with 1866 incident conditions (median 10-year follow-up) 88 quantitative traits...
Translation of the yeast mitochondrial mRNA encoding cytochrome c oxidase subunit III (coxIII) is specifically activated by products at least three nuclear genes, PET494, PET54, and PET122. To investigate whether target site for translational activation within 5' untranslated leader coxIII mRNA, we asked translation another protein, apo-cytochrome b, from a chimeric bearing required or Mutations in any these genes abolished b an two-thirds leader, showing that all gene are must act leader....
The Saccharomyces Genome Database (SGD; http://www.yeastgenome.org) is a scientific database for the molecular biology and genetics of yeast cerevisiae, which commonly known as baker's or budding yeast. information in SGD includes functional annotations, mapping sequence information, protein domains structure, expression data, mutant phenotypes, physical genetic interactions primary literature from these data are derived. Here we describe how published phenotypes interaction annotated displayed SGD.
The Aspergillus Genome Database (AspGD) is an online genomics resource for researchers studying the genetics and molecular biology of Aspergilli. AspGD combines high-quality manual curation experimental scientific literature examining Aspergilli, cutting-edge comparative approaches to iteratively refine improve structural gene annotations across multiple species, web-based research tools accessing exploring data. All these data are freely available at http://www.aspgd.org. We welcome...
The product of Saccharomyces cerevisiae nuclear gene PET494 is known to be required for a posttranscriptional step in the accumulation one mitochondrial product, subunit III cytochrome c oxidase (coxIII). Here we show that protein probably acts mitochondria by demonstrating both PET494-beta-galactosidase fusion and unmodified are specifically associated with mitochondria. To define site action, isolated mutations suppress pet494 deletion. These were rearrangements oxi2 encodes coxIII....
The Saccharomyces Genome Database (SGD; http://www.yeastgenome.org) is the community resource for genomic, gene and protein information about budding yeast cerevisiae, containing a variety of functional each product. We have recently added regulatory to SGD present it on new tabbed section Locus Summary entitled 'Regulation'. are compiling transcriptional regulator–target relationships, which curated from literature at or imported, with permission, YEASTRACT database. For nearly every S....
Abstract We have found that agitation of Saccharomyces cerevisiae with glass beads and plasmid DNA using a vortex mixer results in genetic transformation the yeast cells. This method is less efficient, but considerably more convenient, than other procedures. The fact minimal requirements for are simply physical damage presence an osmotically supportive environment suggests this process may occur nature.