A5102985565- Bioactive Compounds and Antitumor Agents
- Genomics and Rare Diseases
- Phytochemistry and biological activity of medicinal plants
- Bioinformatics and Genomic Networks
- Biomedical Text Mining and Ontologies
- Genetic Associations and Epidemiology
- Fish Biology and Ecology Studies
- COVID-19 Clinical Research Studies
- Microbial Natural Products and Biosynthesis
- Fish Ecology and Management Studies
- Ichthyology and Marine Biology
- Carbohydrate Chemistry and Synthesis
- RNA Interference and Gene Delivery
- Phytochemical compounds biological activities
- Epigenetics and DNA Methylation
- Clostridium difficile and Clostridium perfringens research
- Research studies in Vietnam
- Polysaccharides and Plant Cell Walls
- Medicinal Plants and Neuroprotection
- International Student and Expatriate Challenges
- Global Education and Multiculturalism
- Diphtheria, Corynebacterium, and Tetanus
- Cholinesterase and Neurodegenerative Diseases
- Morinda citrifolia extract uses
- Genomics and Phylogenetic Studies
Broad Institute
2022-2025
University of North Carolina at Chapel Hill
2023
Tân Tạo University
2023
Regenxbio (United States)
2023
UNC Lineberger Comprehensive Cancer Center
2023
Sun Moon University
2017-2022
National Yang Ming Chiao Tung University
2022
Government of the Republic of Korea
2017
University of Economics and Law
2015
University of Economics Ho Chi Minh City
2015
Associations between human genetic variation and clinical phenotypes have become a foundation of biomedical research. Most repositories these data seek to be disease-agnostic therefore lack disease-focused views. The Type 2 Diabetes Knowledge Portal (T2DKP) is public resource datasets genomic annotations dedicated type diabetes (T2D) related traits. Here, we make the T2DKP more accessible prospective users useful existing users. First, evaluate T2DKP's comprehensiveness by comparing its with...
The human retina is a multilayered tissue that offers unique window into systemic health. Optical coherence tomography (OCT) widely used in eye care and allows the noninvasive, rapid capture of retinal anatomy exquisite detail. We conducted genotypic phenotypic analyses layer thicknesses using macular OCT images from 44,823 UK Biobank participants. performed cross-phenotype association (OCT-XWAS), associating with 1866 incident conditions (median 10-year follow-up) 88 quantitative traits...
Angiotensin-converting enzyme 2 (ACE2), part of the renin-angiotensin system (RAS), serves as an entry point for SARS-CoV-2, leading to viral proliferation in permissive cell types. Using mouse lines which Ace2 locus has been humanized by syntenic replacement, we show that regulation basal and interferon induced ACE2 expression, relative expression levels different transcripts, sexual dimorphism are unique each species, differ between tissues, determined both intragenic upstream promoter...
<title>Abstract</title> Rare coding variant association studies typically perform gene-level tests in which variants are filtered (or “masked”) and aggregated based on functional annotation allele frequency. As there is little research no consensus regarding masking strategies to use, we investigated the impact of burden tests, most widely used interpretable type aggregate test. A systematic review 234 catalogued 664 masks that rarely repeated across studies. Analyzing 54 traits within...
Coronavirus disease 2019 (COVID-19) remains a threat with the emergence of new variants, especially Delta and Omicron, without specific effective therapeutic drugs. The infection causes dysregulation immune system cytokine storm that eventually leads to fatal acute respiratory distress syndrome (ARDS) further irreversible pulmonary fibrosis. Therefore, promising way inhibit is disrupt binding fusion between viral spike host ACE2 receptor. A transcriptome-based drug screening platform has...
Biosynthesis of various genistein glycopyranoside scaffolds using versatile GTs and SOMTs. Each compound was structurally characterized biological activity assay carried out.
Anthraquinones, naturally occurring bioactive compounds, have been reported to exhibit various biological activities, including anti-inflammatory, antiviral, antimicrobial, and anticancer effects. In this study, we biotransformed three selected anthraquinones into their novel O-glucoside derivatives, expressing a versatile glycosyltransferase (YjiC) from Bacillus licheniformis DSM 13 in Escherichia coli. Anthraflavic acid, alizarin, 2-amino-3-hydroxyanthraquinone were exogenously fed...
The use of adeno-associated viruses (AAVs) as gene delivery vectors has vast potential for the treatment many severe human diseases. Over one hundred naturally existing AAV capsid variants have been described and classified into phylogenetic clades based on their sequences. AAV8, AAV9, AAVrh.10, other intensively studied capsids propelled pre-clinical clinical use, more recently, marketed products; however, less-studied may also desirable properties (e.g., potency differences, tissue...
Advances in computer science are continuing to help expand a new subfield of ecology based on computational analyses complex ecological networks where the nonlinear dynamics many interacting species can be more realistically modeled and understood. Research has recently elucidated how network structure feeding relationships both generally stabilize ecosystems also specifically predict effects experimentally removing species. Still, further research is inhibited by exponential increase...
Methyltransferases transfer a methyl group to diverse of natural products, thus providing structural diversity, stability, and altered pharmacological properties the molecules. A limited number regiospecific sugar-
Rhamnose is a naturally occurring deoxysugar present as glycogenic component of plant and microbial natural products. A recombinant mutant Escherichia coli strain was developed by overexpressing genes involved in the TDP-L-rhamnose biosynthesis pathway different bacterial strains Saccharothrix espanaensis rhamnosyl transferase to conjugate intrinsic cytosolic with anthraquinones supplemented exogenously. Among five (alizarin, emodin, chrysazin, anthrarufin, quinizarin) tested, quinizarin...
Abstract Although large-scale genetic association studies have proven useful for the delineation of neurodegenerative disease processes, we still lack a full understanding pathological mechanisms these diseases, resulting in few appropriate treatment options and diagnostic challenges. To mitigate gaps, Neurodegenerative Disease Knowledge Portal (NDKP) was created as an open-science initiative with aim to aggregate, enable analysis, display all available genomic datasets disease, while...
Presently reported study examined the length–weight relations for 11 goby species collected from a mangrove estuary of Red River, Vietnam. A total 1097 individuals following species, representing three families, were analyzed: Butis butis (Hamilton, 1822); koilomatodon (Bleeker, 1849); Acentrogobius moloanus (Herre, 1927); viridipunctatus (Valenciennes, 1837); Apocryptodon madurensis Aulopareia unicolor Glossogobius giuris Gobiopsis macrostoma Steindachner, 1861; Mugilogobius abei (Jordan et...
The internationalization of higher education is a common development trend universities in the world.For Vietnam, globalization education, most important which an essential and vital issue country's strategy.However, at same time, international context also posing many challenges for Vietnam when it comes to competitiveness highlyqualified workers relation other countries region, existing skill gap good post-graduates, brain drain phenomenon, etc.Besides analyzing current trends their...
Presently reported study examined the length–weight relations for 11 goby species collected from a mangrove estuary of Red River, Vietnam. A total 1097 individuals following species, representing three families, were analyzed: Butis butis (Hamilton, 1822); koilomatodon (Bleeker, 1849); Acentrogobius moloanus (Herre, 1927); viridipunctatus (Valenciennes, 1837); Apocryptodon madurensis Aulopareia unicolor Glossogobius giuris Gobiopsis macrostoma Steindachner, 1861; Mugilogobius abei (Jordan et...
This paper aims to answer whether there is a difference in the choice and consumption of domestic imported fruits at supermarkets Ho Chi Minh city if yes, it can be measured. To these questions, we employ structural equation model (SEM) with four variables, including product quality feature, brand, price, personal behavior consumers. The subsequently checked using confirmatory factor analysis (CFA). Data obtained from surveys on fruit consumers HCMC’s conducted October December, 2013....