A5047341378- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Retinal Diseases and Treatments
- Corneal surgery and disorders
- Retinal and Optic Conditions
- Ophthalmology and Visual Impairment Studies
- Visual perception and processing mechanisms
- Cerebral Venous Sinus Thrombosis
- Intraocular Surgery and Lenses
- Ocular Surface and Contact Lens
- Ophthalmology and Eye Disorders
- Corneal Surgery and Treatments
- Ocular Diseases and Behçet’s Syndrome
- Color Science and Applications
- Industrial Vision Systems and Defect Detection
- Ocular Infections and Treatments
- Face Recognition and Perception
- Acute Ischemic Stroke Management
- Retinal Development and Disorders
- Ophthalmology and Visual Health Research
- Retinal and Macular Surgery
- AI in cancer detection
- Neural dynamics and brain function
- Genetic Associations and Epidemiology
- Face recognition and analysis
Harvard University
2016-2025
Massachusetts Eye and Ear Infirmary
2016-2025
Smith-Kettlewell Eye Research Institute
2016-2025
Leipzig University
2017-2025
Harvard University Press
2023
LMU Klinikum
2022
Singapore Eye Research Institute
2019-2022
Icahn School of Medicine at Mount Sinai
2021
Max Planck Institute for Mathematics in the Sciences
2010-2020
Max Planck Institute for Mathematics
2010-2020
The microvasculature, the smallest blood vessels in body, has key roles maintenance of organ health and tumorigenesis. retinal fundus is a window for human vivo noninvasive assessment microvasculature. Large-scale complementary machine learning-based vasculature with phenome-wide genome-wide analyses may yield new insights into disease.
Glaucoma is an optic neuropathy accompanied by vision loss which can be mapped visual field (VF) testing revealing characteristic patterns related to the retinal nerve fibre layer anatomy. While detailed knowledge about these important understand anatomic and genetic aspects of glaucoma, current classification schemes are typically predominantly derived qualitatively. Here, we classify glaucomatous quantitatively statistically learning prototypical on convex hull data space. In contrast...
To detect visual field (VF) progression by analyzing spatial pattern changes.We selected 12,217 eyes from 7360 patients with at least five reliable 24-2 VFs and 5 years of follow-up an interval 6 months. were decomposed into 16 archetype patterns previously derived artificial intelligence techniques. Linear regressions applied to the weights VF series over time. We defined as decrease rate normal or any increase 15 defect archetypes be outside limits. The method was compared mean deviation...
Journal Article Cohort Profile: The LIFE-Adult-Study Get access Christoph Engel, Engel Institute for Medical Informatics, Statistics and Epidemiology, Leipzig University, Leipzig, GermanyLeipzig Research Centre Civilization Diseases, Germany Corresponding author. Haertelstrasse 16–18, 04107 Germany. E-mail: christoph.engel@imise.uni-leipzig.de https://orcid.org/0000-0002-7247-282X Search other works by this author on: Oxford Academic PubMed Google Scholar Kerstin Wirkner, Wirkner Samira...
Glaucoma is a progressive optic neuropathy and leading cause of irreversible blindness worldwide. Primary open-angle glaucoma the most common form, yet etiology this multifactorial disease poorly understood. We aimed to identify plasma metabolites associated with risk developing POAG in case-control study (599 cases 599 matched controls) nested within Nurses' Health Studies, Professionals' Follow-Up Study. Plasma were measured LC-MS/MS at Broad Institute (Cambridge, MA, USA); 369 from 18...
Accurate diagnosis and timely management are vital for favorable uveitis outcomes. Artificial Intelligence (AI) holds promise in medical decision-making, particularly ophthalmology. Yet, the diagnostic precision advice from AI-based chatbots lack assessment.
The human retina is a multilayered tissue that offers unique window into systemic health. Optical coherence tomography (OCT) widely used in eye care and allows the noninvasive, rapid capture of retinal anatomy exquisite detail. We conducted genotypic phenotypic analyses layer thicknesses using macular OCT images from 44,823 UK Biobank participants. performed cross-phenotype association (OCT-XWAS), associating with 1866 incident conditions (median 10-year follow-up) 88 quantitative traits...
To assess the diagnostic performance of two chatbots, ChatGPT and Glass, in uveitis diagnosis compared to renowned specialists, evaluate clinicians' perception about utilizing artificial intelligence (AI) ophthalmology practice.
Better understanding of primary open-angle glaucoma (POAG) genetics could enable timely screening and promote individualized disease risk prognostication.
Abstract Aims/hypothesis As the prevalence of insulin resistance and glucose intolerance is increasing throughout world, diabetes-induced eye diseases are a global health burden. We aim to identify distinct optical bands which closely related metabolism, using non-invasive, high-resolution spectral domain coherence tomography (SD-OCT) in large, population-based dataset. Methods The LIFE-Adult-Study randomly selected 10,000 participants from population registry Leipzig, Germany....
Fairness (also known as equity interchangeably) in machine learning is important for societal well-being, but limited public datasets hinder its progress. Currently, no dedicated medical with imaging data fairness are available, though underrepresented groups suffer from more health issues. To address this gap, we introduce Harvard Glaucoma (Harvard-GF), a retinal nerve disease dataset including 3,300 subjects both 2D and 3D balanced racial glaucoma detection. the leading cause of...
The study investigates long-term recognition memory in congenital prosopagnosia (CP), a lifelong impairment face identification that is present from birth. Previous investigations of processing deficits CP have mostly relied on short-term tests to estimate the scope and severity individual deficits. We firstly report controlled test (one year) for faces objects conducted with large group participants CP. Long-term significantly impaired eight (CPs). In all but one case, this deficit was...