A5067773498- Stress Responses and Cortisol
- Hormonal and reproductive studies
- Hormonal Regulation and Hypertension
- Adrenal Hormones and Disorders
- Eating Disorders and Behaviors
- Thyroid Cancer Diagnosis and Treatment
- Growth Hormone and Insulin-like Growth Factors
- Estrogen and related hormone effects
- Vitamin D Research Studies
- Immunodeficiency and Autoimmune Disorders
- Child and Adolescent Psychosocial and Emotional Development
- Childhood Cancer Survivors' Quality of Life
- Infant Nutrition and Health
- Neuroendocrine Tumor Research Advances
- Hypothalamic control of reproductive hormones
- Pituitary Gland Disorders and Treatments
- Obesity and Health Practices
- Exercise and Physiological Responses
- Regulation of Appetite and Obesity
- Analytical Chemistry and Chromatography
- Atrial Fibrillation Management and Outcomes
- Nutritional Studies and Diet
- Sex and Gender in Healthcare
- Thyroid and Parathyroid Surgery
- Health, Environment, Cognitive Aging
Friedrich-Ebert-Stiftung e.V.
2025
Medizinisches Versorgungszentrum Prof. Mathey, Prof. Schofer
2025
University Hospital Leipzig
2016-2023
Leipzig University
2015-2020
LG (South Korea)
2013
Journal Article Cohort Profile: The LIFE-Adult-Study Get access Christoph Engel, Engel Institute for Medical Informatics, Statistics and Epidemiology, Leipzig University, Leipzig, GermanyLeipzig Research Centre Civilization Diseases, Germany Corresponding author. Haertelstrasse 16–18, 04107 Germany. E-mail: christoph.engel@imise.uni-leipzig.de https://orcid.org/0000-0002-7247-282X Search other works by this author on: Oxford Academic PubMed Google Scholar Kerstin Wirkner, Wirkner Samira...
Dysregulation of the adrenal cortex has been assessed with measurement salivary cortisol. So far cortisol is routinely measured immunoassay (IA). However, liquid chromatography-tandem mass spectrometry (MS) known to offer better specificity. We compared concentrations by MS and IA at basal stress induced conditions evaluated reasons for difference in method-dependent results.Saliva samples (n=2703) were collected from 169 children (age range: 8-14 years; 81 healthy children; 55 internalizing...
Steroid hormones are important regulators of physiological processes in humans and under genetic control. A link to coronary artery disease (CAD) is supposed.Our main objective was identify loci influencing steroid hormone levels. As a secondary aim, we searched for causal effects on CAD.We conducted genome-wide meta-association studies eight hormones: cortisol, dehydroepiandrosterone sulfate (DHEAS), estradiol, testosterone two independent cohorts (LIFE-Adult, LIFE-Heart, maximum n = 7667),...
Untreated disorders of the adrenocortical system, such as Cushing's or Addison's disease, can be fatal, and accurate quantification a patient's cortisol levels is vital for diagnosis. The objective this study was to assess analytical performance new fully-automated Elecsys® Cortisol II assay (second generation) measure in serum saliva.Four European investigational sites assessed intermediate precision reproducibility (Roche Diagnostics) under routine conditions. Method comparisons vs. liquid...
Sustained-release GH formulations may provide a strategy for improving treatment compliance and persistence in GH-deficient patients. The aim of the study was to examine efficacy safety LB03002, sustained-release formulation once-weekly administration. We conducted phase III, 12-month, multinational, randomized, open-label, comparator-controlled trial with 12-month uncontrolled extension. Prepubertal treatment-naive children (mean age, 7.8 y) participated study. administered LB03002 (n = 91)...
Abstract Accumulating evidence supports a link between depression and being overweight in women. Given previously reported sex differences fat accumulation prevalence, as well the likely role of hormones both mood disorders, we hypothesised that depression-overweight association may be mediated by hormones. To this end, investigated with depression, then considered relation to large population-based cohort. We included total 3124 women, 970 premenopausal 2154 postmenopausal from LIFE-Adult...
Background: Several studies have shown a positive association between anxiety and obesity, particularly in women. We aimed to study whether sex hormone alterations related obesity might play role this association. Patients methods: Data for were obtained from population-based cohort (the LIFE-Adult-Study). A total of 3,124 adult women (970 premenopausal 2,154 postmenopausal) included into the analyses. The symptomatology was assessed using GAD-7 questionnaire (cut-off ≥ 10 points). Sex...
Purpose The purpose of this study was to investigate the efficacy and safety LB03002, a sustained-release human GH (SR-hGH), compared with that daily rhGH for 12 months in children deficiency (GHD). Methods A total 73 GHD were screened 63 eligible subjects randomized 1:1 ratio LB03002 (SR-hGH) treatment group. administered once weekly at dose 0.5 mg/kg while 6 consecutive days equally divided doses make 0.21 per week. Treatments given by s.c. injections. Injection site reactions adverse...
Abstract Background There is only limited information on serum reference ranges of calcitonin (CT) in infants, children and adolescents. This gap hampers valid diagnostics patients with multiple endocrine neoplasia type 2 (MEN 2) planned prophylactic thyroidectomy. In addition, age-dependent for CT are necessary to define a cure medullary thyroid carcinoma (MTC). We asked whether the levels were age- gender-dependent pediatric cohort. Methods A total 6090 samples 2639 subjects LIFE-Child...
Purpose: Frequent changes in chronic urticaria (CU) activity over time can cause psychological stress, which also serves as a trigger of CU.To measure the control status CU, Urticaria Control Test (UCT) was developed Germany.This study aimed to investigate validity, reliability and responsiveness CU for Korean version UCT (K-UCT) its relation with salivary cortisol cortisone levels.Methods: Linguistic adaptation into conducted.A total 96 patients were enrolled, 80 them completed study.The...
Liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) has become state of the art for quantitative analysis steroid hormones. Although method comparisons show that aldosterone measurement using LC-MS/MS yields considerably lower levels than immunoassays (IAs), method-specific cutoff values primary aldosteronism (PA) are largely missing. Objective this study was analyze diagnostic accuracy proposed LC-MS/MS-specific saline infusion test (SIT).From 2016 2019, 104 consecutive...
In this study, we used a stress test to investigate endocrinological and subjective responses of 8- 14-year-old children with internalizing or externalizing disorders healthy controls. The sample (N = 170) consisted clinical community children. Parents were given diagnostic interview diagnose their children's psychiatric condition. We measured saliva cortisol subjectively experienced arousal in before after the Trier Social Stress Test for Children. Children also rated performance...