A5041432904- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Disease and Adiposity
- Health, Environment, Cognitive Aging
- Cancer Immunotherapy and Biomarkers
- Electrolyte and hormonal disorders
- Liver Disease Diagnosis and Treatment
- Platelet Disorders and Treatments
- Biomarkers in Disease Mechanisms
- Heart Failure Treatment and Management
- Hormonal Regulation and Hypertension
- Antiplatelet Therapy and Cardiovascular Diseases
- Health and Medical Studies
- Enhanced Recovery After Surgery
- Nutritional Studies and Diet
- Cardiac, Anesthesia and Surgical Outcomes
- Stress Responses and Cortisol
- Liver Disease and Transplantation
- Immunotherapy and Immune Responses
- Esophageal Cancer Research and Treatment
- Lipoproteins and Cardiovascular Health
- Cardiac Fibrosis and Remodeling
- Cardiovascular Function and Risk Factors
- Tryptophan and brain disorders
- Inflammatory Biomarkers in Disease Prognosis
- Immune cells in cancer
Leipzig University
2015-2023
University Hospital Leipzig
2018-2022
The LIFE-Adult-Study is a population-based cohort study, which has recently completed the baseline examination of 10,000 randomly selected participants from Leipzig, major city with 550,000 inhabitants in east Germany. It first study this kind and size an urban population eastern part conducted by Leipzig Research Centre for Civilization Diseases (LIFE). Our objective to investigate prevalences, early onset markers, genetic predispositions, role lifestyle factors civilization diseases,...
Journal Article Cohort Profile: The LIFE-Adult-Study Get access Christoph Engel, Engel Institute for Medical Informatics, Statistics and Epidemiology, Leipzig University, Leipzig, GermanyLeipzig Research Centre Civilization Diseases, Germany Corresponding author. Haertelstrasse 16–18, 04107 Germany. E-mail: christoph.engel@imise.uni-leipzig.de https://orcid.org/0000-0002-7247-282X Search other works by this author on: Oxford Academic PubMed Google Scholar Kerstin Wirkner, Wirkner Samira...
Knowledge about cardiac and inflammatory biomarkers in patients with stable coronary artery disease (CAD) is limited. To address this, we analyzed 3072 (36% female) a median follow-up of 10 years the Leipzig LIFE Heart Study suspected CAD angiography. Selected included troponin T (hsTNT), N-terminal pro B-type natriuretic peptide (NT-proBNP), copeptin, C-reactive protein (hsCRP), interleukin-6 (IL-6). Patients were stratified by severity: CAD0 (no sclerosis), CAD1 (non-obstructive, i.e.,...
Abstract Background For many patients with end-stage liver disease, transplantation represents the only curative therapy. Transplant recipients are scored and ranked using model for disease (MELD/MELD-Na). Circulatory impairment is known to deteriorate outcomes; however, it not incorporated into current allocation system’s score. The aim of our study analyze predictive value copeptin as a biomarker circulatory increased short-term mortality risk in disease. Methods We conducted retrospective...
Introduction: Any surgical procedure develops a stress situation for the patient, which can modulate individual outcome. At present, there is only limited information about response in colorectal resections by laparoscopic compared to conventional surgery. Therefore, our objectives were feasibility and investigation of biomarkers including copeptin steroid hormones before, during after surgery.Methods: Eleven patients underwent minimally invasive ten conventionally open Blood samples...
Abstract Introduction Light transmission aggregometry (LTA) is regarded as the gold standard in platelet function diagnostics. However, there a relevant degree of interlaboratory variability practical applications. Objective The aim present study was to develop practicable laboratory comparison on LTA and analyze differences influencing factors regard standardization five specialized hemostaseological centers. Methods performed 30 patients total. Each center blood samples from six healthy...
Abstract Introduction and methods: The knowledge about diagnostic prognostic value of cardiac inflammatory biomarkers in patients with chronic coronary syndrome (CCS) is limited. To address this, we analyzed serum levels selected 2536 suspected CCS (35% female) from the Leipzig LIFE Heart Study who were admitted for angiography. median follow-up was 10 years. following considered: high sensitive troponin T (hsTNT), N-terminal pro B-type natriuretic peptide (NT-proBNP), copeptin, C-reactive...
Abstract The prognosis of patients with advanced esophageal adenocarcinoma (EAC) is still poor, which partly due to a limited chemotherapy response. About 50% these patients, treated neoadjuvant chemotherapy, are non-responder, might by influenced inflammation and immunological conditions. EAC (n = 24) were characterized prospectively in single center study for gender (female n 4; male 20), age (median 64; range 43-77 years), TNM-classification, pathological response rate (PRR) chemotherapy....
Die Langzeitprognose von Patienten mit ösophagealem Adenokarzinom ist trotz verbesserter Therapiealgorithmen begrenzt. Lediglich 50 % der sprechen auf die neodjuvante Chemotherapie im Sinne einer adäquaten pathologischen Response an. Möglicherweise spielt immunologische Konstitution und das systemische Inflammationsgeschehen hierfür eine Rolle.