A5101629003- Dementia and Cognitive Impairment Research
- Helicobacter pylori-related gastroenterology studies
- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Substance Abuse Treatment and Outcomes
- Cell Adhesion Molecules Research
- Opioid Use Disorder Treatment
- Impact of Technology on Adolescents
- Dialysis and Renal Disease Management
- Traditional Chinese Medicine Studies
- Cellular Mechanics and Interactions
- Wnt/β-catenin signaling in development and cancer
- Suicide and Self-Harm Studies
- Eating Disorders and Behaviors
- Ion Channels and Receptors
- Functional Brain Connectivity Studies
- Respiratory viral infections research
- Mesenchymal stem cell research
- Child and Adolescent Psychosocial and Emotional Development
- Advanced MRI Techniques and Applications
- Child Development and Digital Technology
- Acute Ischemic Stroke Management
- Clostridium difficile and Clostridium perfringens research
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Bipolar Disorder and Treatment
Kaohsiung Medical University
2016-2025
Kaohsiung Medical University Chung-Ho Memorial Hospital
2016-2025
China Medical University Hospital
2018-2025
National Cheng Kung University
2010-2023
China Medical University
2007-2023
Chang Gung University
2023
National Taiwan Normal University
2023
National Tsing Hua University
2007-2022
University of Oxford
2014-2022
National Taiwan University Hospital
2019-2021
<h3>Objectives</h3> To evaluate the predictive values of psychiatric symptoms for occurrence Internet addiction and to determine sex differences in value adolescents. <h3>Design</h3> addiction, depression, attention-deficit/hyperactivity disorder, social phobia, hostility were assessed by self-reported questionnaires. Participants then invited be 6, 12, 24 months later (the second, third, fourth assessments, respectively). <h3>Setting</h3> Ten junior high schools southern Taiwan....
Abstract Background Coping strategies are a potential way to improve interventions designed manage the caregiver burden of dementia. The purpose this study was develop an intervention targeted towards improving coping and examine its effectiveness on reducing burden. Methods A controlled design used. Fifty‐seven caregivers dementia patients were enrolled. assessed with R evised W ays C oping hecklist ( WCCL‐R ) hinese version aregiver B urden I nventory. participants randomly divided into...
Focal adhesion (FA) assembly, mediated by integrin activation, responds to matrix stiffness; however, the underlying mechanisms are unclear. Here, we showed that β1 and caveolin-1 (Cav1) levels were decreased with declining stiffness. Soft selectively downregulated endocytosis subsequent lysosomal degradation. Disruption of lipid rafts methyl-β-cyclodextrin or nystatin, knockdown Cav1 siRNA cell spreading, FA protein in cells cultured on stiff matrix. Overexpression Cav1, particularly...
People diagnosed with Internet gaming disorder (IGD) have been frequently reported to experience depression, anxiety, and hostility. Emotional regulation contributes these mood symptoms. This study evaluated emotional in subjects IGD examined relationships between regulation, hostility young adults IGD. We recruited 87 people a control group of without history All participants underwent diagnostic interview based on the criteria Diagnostic Statistical Manual Mental Disorders, Fifth Edition,...
Autonomic imbalance is considered a psychopathological mechanism underlying major depressive disorder (MDD). Heart rate variability (HRV) an index for autonomic activation. Poor sleep quality common among patients with MDD. HRV biofeedback (BF) has been used regulating balance physical illness and mental disorders. The purpose of present study was to examine the effects HRV-BF on symptoms, quality, pre-sleep arousal, indices, in MDD insomnia.In this case-controlled study, Pittsburgh Sleep...
Influenza A viruses are major human and animal pathogens with huge economic societal impact from illness, hospitalizations, deaths. Virus-like particles (VLPs) of influenza virus have been suggested as a vaccine candidate offering improved safety efficacy. To develop this concept further, we established flexible platform to efficiently generate different subtypes mammalian-expressed VLPs. Here demonstrate that these mammalian VLPs strongly resemble the authentic in structure, particle size...
Hypoxia inducible factor-1 (HIF-1) is the master transcriptional regulator of cellular response to altered oxygen levels. HIF-1α protein elevated in most solid tumors and contributes poor disease outcome by promoting tumor progression, metastasis, resistance chemotherapy. To date, relationship between HIF-1 these processes, particularly chemoresistance, has remained largely unexplored. Here, we show that expression MAPK-specific phosphatase dual-specificity phosphatase-2 (DUSP2) markedly...
Cell transplantation is a promising approach for patients with myocardial infarction. However, following injection, retention of the transplanted cells in injected area remains central issue, which can be deleterious to cell therapy. We hypothesized that use sheet fragments, preservation extracellular matrix (ECM), may significantly increase and thus improve Mesenchymal stem (MSC) fragments ECM were fabricated. Experimental infarction was created male syngeneic Lewis rats. Thirty minutes...
Background: A good quality of life (QOL) is associated with successful treatment in patients opioid dependence. Therefore, it clinical benefit to examine what factors can predict a change QOL among heroin users the course methadone maintenance (MMT) program. Objectives: This longitudinal study aimed patterns and predictors during period an 18-month MMT Methods: total 368 intravenous receiving southern Taiwan between 2007 2008 were interviewed using version Brief Version World Health...
Discoidin domain receptor 1 (DDR1) promotes E-cadherin-mediated adhesion. The underlying mechanism and its significance, however, have not been elucidated. Here we show that DDR1 overexpression augmented, whereas dominant negative mutant (DN-DDR1) or knockdown of inhibited E-cadherin localized in cell-cell junctions epithelial cells. changed the localization abundance E-cadherin, as well plasticity, manifested by enhancement microvilli formation alteration cytoskeletal organization. also...
Background: This study aims to examine whether coping strategies employed by caregivers are related distinct symptoms of patients with dementia and investigate the associations between burden among dementia. Methods: A cross-sectional design was used. total 57 were enrolled. Coping assessed using Ways Checklist, Chinese version Caregiver Burden Inventory. Correlations patients’ behavior or memory problems examined. Severities adjusted correlations caregiver strategies. Results: The...