A5002433263- Acute Myeloid Leukemia Research
- Heavy Metal Exposure and Toxicity
- Epigenetics and DNA Methylation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Air Quality and Health Impacts
- Birth, Development, and Health
- Ubiquitin and proteasome pathways
- Cancer Genomics and Diagnostics
- Multiple Myeloma Research and Treatments
- Hematopoietic Stem Cell Transplantation
- MicroRNA in disease regulation
- Protein Tyrosine Phosphatases
- Cytokine Signaling Pathways and Interactions
- Pulmonary Hypertension Research and Treatments
- Healthcare and Environmental Waste Management
- Pregnancy and preeclampsia studies
- Recycling and Waste Management Techniques
- Blood disorders and treatments
- Retinoids in leukemia and cellular processes
- Acute Lymphoblastic Leukemia research
- Toxic Organic Pollutants Impact
- Eicosanoids and Hypertension Pharmacology
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Ovarian function and disorders
Shantou University
2015-2025
Shantou University Medical College
2015-2025
University Medical Center Groningen
2018-2024
University of Groningen
2018-2024
University Medical Center Utrecht
2024
Nanchang University
2021-2023
Jinan University
2022
Guizhou University
2022
Guangzhou Medical University
2019-2021
Second Affiliated Hospital of Guangzhou Medical University
2019-2021
Environmental exposure to carcinogenic polycyclic aromatic hydrocarbons (PAHs) can disturb the immune response. However, effect of PAHs on low-grade inflammation related platelets in humans is unknown. We investigated association PAH with and platelet parameters healthy preschoolers. The present study recruited 239 participants, aged 2–7 years, from an electronic-waste (e-waste)-exposed (n = 118) a reference 121) area. measured ten urinary metabolites, four types cells cytokines, seven...
Polycyclic aromatic hydrocarbons (PAHs), as a group of persistent organic pollutants, are linked to impaired immune function and low-grade inflammation in adults children. However, the potential PAHs lead cytokine storm associated with AhR (aryl hydrocarbon receptor) NLRP3 (NLR family pyrin domain containing 3) humans has been poorly studied. We aimed investigate associations between PAH exposure, expression, cytokines healthy preschoolers. Basic demographic surveys physical examinations...
Abstract The mammalian target of rapamycin (mTOR) inhibitor, DNA damage inducible transcript 4 (DDIT4), has expression in response to various cellular stresses. In multiple malignancies, studies have shown that DDIT4 participates tumorigenesis and impacts patient survival. We aimed study the prognostic value acute myeloid leukaemia (AML), which is currently unclear. Firstly, Cancer Genome Atlas was screened for AML patients with complete clinical characteristics data. A total 155 were...
Abstract Heavy metals disrupt mitochondrial function and activate the NOD‐like receptor pyrin‐containing 3 (NLRP3) inflammasome. We investigated effect of lead (Pb)/cadmium (Cd) on NLRP3 inflammasome activation in human trophoblast under normoxic, hypoxic pro‐inflammatory conditions. JEG‐3, BeWo HTR‐8/SVneo cells were exposed to Pb or Cd for 24 h absence presence hypoxia lipopolysaccharide (LPS) poly(I:C). Then, we evaluated cell viability, apoptosis, DNA copy number (mtDNAcn), membrane...
Acute myeloid leukemia (AML) is a highly heterogenous hematological malignancy and its prognostication depends on the genetic mutation expression profile of each patient. Pantothenate kinase (PANK) regulatory enzyme that controls coenzyme A (CoA) biosynthesis. It has four isoforms encoded by PANK1-4, respectively. Whether PANK family prognostic significance in AML remains unclear.We screened The Cancer Genome Atlas database for patients with complete PANK1-4 data. Eighty-four met criteria...
DOCK family proteins are evolutionarily conserved guanine nucleotide exchange factors for Rho GTPase with different cellular functions. It has been demonstrated that DOCK1 had adverse prognostic effect in acute myeloid leukemia (AML). We first analyzed data of 85 AML patients who were treated chemotherapy and available to DOCK11 expression information found DOCK2 significance AML. In view the known prognosis AML, we then explored role DOCK2. One hundred fifty-six extracted from The Cancer...