A5021352155- Glioma Diagnosis and Treatment
- Natural product bioactivities and synthesis
- Immune cells in cancer
- Phytochemistry and Biological Activities
- Immune Response and Inflammation
- Functional Brain Connectivity Studies
- Spine and Intervertebral Disc Pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- Protein Degradation and Inhibitors
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Migraine and Headache Studies
- Antiplatelet Therapy and Cardiovascular Diseases
- Musculoskeletal pain and rehabilitation
- MicroRNA in disease regulation
- Melanoma and MAPK Pathways
- Ubiquitin and proteasome pathways
- Traditional Chinese Medicine Analysis
- Metabolism and Genetic Disorders
- Chromatography in Natural Products
- Cancer Mechanisms and Therapy
- Drug-Induced Hepatotoxicity and Protection
- Anesthesia and Pain Management
- Platelet Disorders and Treatments
- Telomeres, Telomerase, and Senescence
Xuzhou Medical College
2015-2025
Shanxi Medical University
2025
Nanjing University of Chinese Medicine
2024
Capital Medical University
2021-2022
Nanjing Medical University
2015-2022
Chengdu University
2016-2022
Nanjing Brain Hospital
2019-2022
Cal Humanities
2022
Guangdong Medical College
2022
Hebei Medical University
2022
Glutathione (GSH) and GSH-related enzymes constitute the most important defense system that protects cells from free radical, radiotherapy, chemotherapy attacks. In this study, we aim to explore potential role regulatory mechanism of GSH redox cycle in drug resistance glioblastoma multiforme (GBM) cells. We found temozolomide (TMZ)-resistant glioma displayed lower levels endogenous reactive oxygen species higher total antioxidant capacity than sensitive Moreover, expression glutathione...
Context Oxidative stress and inflammation are implicated in the aging process its related hepatic renal function decline. Chlorogenic acid (CGA) is one of most abundant polyphenol compounds human diet. Recently, CGA has shown vivo vitro antioxidant properties.Objective The current study investigates effects protective chlorogenic on d-galactose-induced liver kidney injury.Materials methods Hepatic injuries were induced a mouse model by subcutaneously injection d-galactose (d-gal; 100 mg/kg)...
Abstract Mitochondria-related microRNAs (miRNAs) have recently emerged as key regulators of cell metabolism and can modulate mitochondrial fusion division. In order to investigate the roles mitochondria-related miRNAs played in obesity, we conducted comprehensive molecular analysis vitro vivo . Based on high-fat-diet (HFD) induced obese mice, found that hepatic function was markedly altered. Subsequently, evaluated expression levels selected miR-141-3p up-regulated strikingly HFD mice. To...
Scope Oxidative stress is involved in chronic stress‐induced depression and the disruption of neurotransmission neuroplasticity. Recently, orientin, a phenolic compound abundant some fruits, millet, herbs, has been shown to have antioxidant properties. This study investigated potential antidepressant effects orientin against its underlying mechanisms. Methods results The unpredictable mild (CUMS) model was used investigate on behavior biochemical alterations mice. After 2 weeks CUMS...
Summary Controlling platelet granule secretion has been considered an effective strategy to dampen thrombosis and prevent atherosclerosis. Anthocyanins are natural plant pigments possess a wide range of biological activities, including cardiovascular protective activity. In the present study we explored effects potential mechanisms anthocyanins on in hypercholesterolemia. randomised, double-blind clinical trial, 150 hypercholesterolaemic individuals were treated with purified (320 mg/day) or...
This study aimed to investigate the effects of polysaccharide from Angelica and Astragalus (AAP) on carbon tetrachloride (CCl 4 ) induced liver damage in mice. A total 120 Kunming mice were randomly distributed among 6 groups comprising (i) normal control mice, (ii) CCl treatment group, (iii) bifendate (iv) AAP (v) sinensis (ASP) (vi) membranaceus (AMP) group. AAP, ASP AMP administered treated with . The activities alanine transaminase (ALT) aspartate (AST) serum, superoxide dismutase (SOD)...
In Brief Study Design. Histological features of the intervertebral disc (IVD)-endplate interface were analyzed. Objective. To define cartilaginous and bony vertebral endplate in commonly used laboratory animals compare with that humans. Summary Background Data. Endplates are crucial for IVD nutrient supply: IVDs have limited blood supply; most nutrients diffuse through endplates to nourish discs. Various animal models degeneration been study etiology treatments spinal disorders. However,...
Abstract Acute lung injury (ALI) is an acute and progressive hypoxic respiratory failure that could progress to distress syndrome (ARDS) with a high mortality rate, thus immediate medical attention supportive care are necessary. The pathophysiology of ALI characterized by the disruption alveolar-capillary barrier activation neutrophils, leading tissue damage. receptor-interacting protein kinase 1 (RIPK1) has emerged as promising target for treatment multiple inflammatory diseases, but role...
Although altered neural networks have been demonstrated in recent MEG (magnetoencephalography) research migraine patients during resting state, it is unknown whether this alteration can be detected task-related networks. The present study aimed to investigate the abnormalities of frequency-specific somatosensory-related network by using MEG.Twenty-two migraineurs interictal phase and twenty-two sex- age-matched healthy volunteers were studied a whole-head magnetoencephalography (MEG) system....
Diosmetin (Dios) is a bioflavonoid mainly isolated from citrus fruits with some health-promoting properties. Recently, diosmetin has been investigated as promising agent for treating neurodegenerative diseases. However, the poor water solubility of restricts its application in various fields. Herein, this study developed novel lactoferrin modified long-circulating liposomes (Lf-Lcl) using thin-film dispersion-ultrasound method brain-targeted delivery potential implications Alzheimer's...
Esophageal squamous cell carcinoma (ESCC) is the most prevalent primary malignant esophageal tumor in China and has a poor prognosis, but lacks effective diagnostic prognostic biomarkers. Through single-sample gene set enrichment analysis (ssGSEA), we conducted immune genomic based on 28 features using transcriptomic data from 155 ESCC cases. We established of two subtypes characterized by high low profiles, 352 differentially expressed genes were identified between subtypes. Performed with...
Abstract Background Mitogen‐activated protein kinase 4 (MAPK4) is an atypical member of the mitogen‐activated (MAPK) family. We report here that MAPK4 overexpressed in glioma. The clinical significance, biological roles and underlying molecular mechanisms through which acts glioma remain unclear. Methods Analysis expression associated survival patients was performed based on data obtained from Cancer Genome Atlas (TCGA) Chinese Glioma (CGGA) databases confirmed human tissue by...
In traditional therapy with Chinese medicine, vitexin has several pharmacological properties, including antinociceptive, antispasmodic, antioxidant, antimyeloperoxidase, and α-glucosidase inhibitory activities. Recently, was shown to protect the heart against ischemia/reperfusion injury in an vitro model by inhibiting apoptosis. The purpose of this study find out whether influences effect on rat cytochrome P450 (CYP) enzymes (CYP1A2, CYP2C11, CYP3A1) using cocktail probe drugs vivo;...