A5101800964- Functional Brain Connectivity Studies
- Migraine and Headache Studies
- Epilepsy research and treatment
- Nanoplatforms for cancer theranostics
- EEG and Brain-Computer Interfaces
- Neuroscience and Neuropharmacology Research
- Dementia and Cognitive Impairment Research
- Immune cells in cancer
- Trigeminal Neuralgia and Treatments
- Sleep and Wakefulness Research
- Natural Compounds in Disease Treatment
- Cancer Immunotherapy and Biomarkers
- Neurogenetic and Muscular Disorders Research
- Photodynamic Therapy Research Studies
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Neuroscience of respiration and sleep
- Vestibular and auditory disorders
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Cancer-related cognitive impairment studies
- Dietary Effects on Health
- Neurosurgical Procedures and Complications
- Optical Imaging and Spectroscopy Techniques
- Cancer Treatment and Pharmacology
- Menopause: Health Impacts and Treatments
Nanjing Medical University
2014-2025
Jiangsu Province Hospital
2006-2025
Nanjing University of Chinese Medicine
2024
Shanghai Institute of Materia Medica
2022-2024
Chinese Academy of Sciences
2022-2024
Nanjing University
2024
Nanjing General Hospital of Nanjing Military Command
2024
Central South University
2021-2022
Second Xiangya Hospital of Central South University
2022
Third Xiangya Hospital
2021
Human sperm cryopreservation in assisted reproductive technology is the only proven method that enables infertile men to father their own children. However, freezing and thawing reduces spermatozoon motility, viability, fertilizing ability. An association between dysfunctional spermatozoa due cryoinjury protein changes has not been established. We investigated through proteomic analysis differential characteristics freeze-thawed fresh samples obtained from nine normozoospermic donors....
Despite significant advances in neuroscience, the mechanisms of AD are not fully understood. Single-cell RNA sequencing (scRNA-seq) techniques provide potential solutions to analyze cellular composition complex brain tissue and explore molecular biological AD.We investigated heterogeneity via utilization bioinformatic analysis scRNA-seq patients healthy controls from Gene Expression Omnibus (GEO) database. The "GOplot" package was applied possible processes oligodendrocytes, astrocytes,...
Oxygen glucose deprivation/re-oxygenation (OGD/R) induces neuronal injury via mechanisms that are believed to mimic the pathways associated with brain ischemia. In SH-SY5Y cells and primary murine neurons, we report OGD/R accumulation of microRNA miR-422a, leading downregulation miR-422a targets myocyte enhancer factor-2D (MEF2D) mitogen-activated protein kinase 6 (MAPKK6). Ectopic inhibition attenuated OGD/R-induced cell death apoptosis, whereas overexpression induced significant apoptosis....
Abstract The red blood cell membrane (RBCm) provides tight protection, lowers the immunogenicity, and prolongs circulation time of drugs in vivo when acting as coating drug delivery systems. However, cellular uptake release are hindered by RBCm. Docetaxel (DTX) is first‐line medicine for treating triple‐negative breast cancer (TNBC), but it induces tumor metastasis. To solve these dilemmas, this study, photosensitizer 1,1‐dioctadecyl‐3,3,3,3‐tetramethylindotricarbocyanine iodide...
As an intermediate state between normal aging and dementia, mild cognitive impairment (MCI), especially amnestic MCI (aMCI), is a key stage in the prevention intervention of Alzheimer's disease (AD). Whether dancing could increase hippocampal volume seniors with aMCI remains debatable. The aim this study was to investigate influence aerobic dance on cognition after 3 months older adults aMCI. In randomized controlled trial, 68 elderly people were either group or control using 1:1 allocation...
Recent advances in migraine research have shown that the cerebral cortex serves a primary role pathogenesis of migraine. Since aberrant brain activity can be noninvasively detected with magnetoencephalography (MEG), The object this study was to investigate resting state cortical differences between migraineurs and controls its related clinical characteristics.Twenty-two subjects an acute twenty-two age- gender-matched were studied using MEG. MEG recordings recorded 120 seconds during...
One of the most important reasons underlying resistance tumors is immune suppression induced by cancer cells. Myeloid-derived suppressor cells (MDSCs), which exerts pivotal functions in immunosuppression, a key participator tumor microenvironment and novel target for therapy. Here curcumin (Cur) was employed as specific MDSCs repressor to inhibit number function MDSCs. Moreover, self-assembled nano-filament system generated through conjugation Cur peptide. In vivo study demonstrated powerful...
Inside the tumor microenvironment, a complicated immunosuppressive network is constituted by cells and suppressive immune as its nodes, including myeloid-derived suppressor (MDSCs), tumor-associated macrophages (TAMs), regulatory T cells, which have mutual promotion on each other superimposed inhibition natural killer (NK) cytotoxic cells. Breaking whole balance of this web critical to immunotherapy since modulation single node may be diluted factors in network. To achieve multifaceted...
Although altered neural networks have been demonstrated in recent MEG (magnetoencephalography) research migraine patients during resting state, it is unknown whether this alteration can be detected task-related networks. The present study aimed to investigate the abnormalities of frequency-specific somatosensory-related network by using MEG.Twenty-two migraineurs interictal phase and twenty-two sex- age-matched healthy volunteers were studied a whole-head magnetoencephalography (MEG) system....
Early diagnosis and accurate prognosis of cognitive decline in Alzheimer's disease (AD) is important to timely assignment optimal treatment modes. We aimed develop a deep learning model predict conversion guide re-assignment decisions more intensive therapies where needed. Longitudinal data including five variable sets, i.e. demographics, medical history, neuropsychological outcomes, laboratory neuroimaging results, from the Disease Neuroimaging Initiative (ADNI) cohort were analyzed. first...
As a well-known anticancer drug, paclitaxel (PTX), first-line chemotherapeutic agent, remains unsatisfactory for gastric cancer therapy. It is reported that triptolide (TPL) could enhance the anti-gastric effect of PTX. Considering poor solubility both drugs, we developed red blood cell membrane-biomimetic nanosystem, an emerging tool in drug delivery, to co-load and (red membrane coated PTX TPL co-loaded poly(lactic-<i>co</i>-glycolic acid) [PLGA] nanoparticles, RP(P/T)). The successful...
Background: Ginkgo biloba extract (GBE) and donepezil have been reported to be effective in patients with Alzheimer’s disease (AD). Nonetheless, how these drugs impact spontaneous brain activities they consequently improve functional recovery are currently unclear. Objectives: This study was explore the efficacy of GBE vs. their add-on on adaption following pharmacologic treatment AD. Methods: Patients AD were enrolled assigned group ( n = 50), or combined 50). Neuropsychological...
Abstract B lymphocytes have emerged as an important immune‐regulating target. Inoculation with tumor cell membrane‐derived vaccines is a promising strategy to activate cells, yet their efficiency limited due lack of costimulatory molecules. To amplify responses against tumor, herein, spatiotemporally‐synchronized antigen‐adjuvant integrated nanovaccine, termed CM‐CpG‐aCD40, constructed by conjugating the immune stimulative CpG oligonucleotide and anti‐CD40 antibody (aCD40) onto membrane...
About 1% of the population around world suffers from epilepsy. The success epilepsy surgery depends critically on pre-operative localization epileptogenic zones. High frequency oscillations including ripples (80-250 Hz) and fast (250-500 are commonly used as biomarkers to localize Recent literature demonstrated that indicate zones better than ripples. Thus, it is crucial accurately detect signals magnetoencephalography for improving outcome surgery. This paper proposes an automatic accurate...
As a long-standing chronic disease, Temporal Lobe Epilepsy (TLE), resulting from abnormal discharges of neurons and characterized by recurrent episodic central nervous system dysfunctions, has affected more than 70% drug-resistant epilepsy patients across the world. etiology clinical symptoms are complicated, differential diagnosis TLE mainly relies on experienced clinicians, specific diagnostic biomarkers remain unclear. Though great effort been made regarding genetics, pathology,...
The reactive oxygen species and Ca2+ overload play a critical role in ischemia/reperfusion (I/R) injury. MCI-186 has potent effects the brain as free radical scavenger ischemia-reperfusion. Acute glucose-oxygen deprivation subsequent reoxygenation were used to model injury cultured hippocampal cells. reduced malondialdehyde level raised SOD activity when applied upon dose-dependent manner compared with untreated group. peak neuroprotective occurred at 100 300 microM. Intracellular calcium...