A5084691239- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Atrial Fibrillation Management and Outcomes
- Cardiac Imaging and Diagnostics
- ECG Monitoring and Analysis
- Preterm Birth and Chorioamnionitis
- Cardiovascular Effects of Exercise
- Neonatal Respiratory Health Research
- Advanced Radiotherapy Techniques
- Cardiac Structural Anomalies and Repair
- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Ion channel regulation and function
- Radiation Therapy and Dosimetry
- Infant Development and Preterm Care
- Advanced MRI Techniques and Applications
- Cardiac tumors and thrombi
- Retinopathy of Prematurity Studies
- Cardiovascular Syncope and Autonomic Disorders
- Medical Imaging Techniques and Applications
- Cardiomyopathy and Myosin Studies
- Neonatal and fetal brain pathology
- Heart Failure Treatment and Management
- Mosquito-borne diseases and control
Washington University in St. Louis
2015-2024
Barnes-Jewish Hospital
2013-2022
Saint Louis University Hospital
2020
Institute of Cardiology
2020
Cardiovascular Research Center
2017
University of Kansas Medical Center
2016
Case Western Reserve University
2016
MetroHealth Medical Center
2016
Johns Hopkins University
2015
Electrophysiology and Heart Modeling Institute
2015
Recent advances have enabled noninvasive mapping of cardiac arrhythmias with electrocardiographic imaging and delivery precise ablative radiation stereotactic body therapy (SBRT). We combined these techniques to perform catheter-free, electrophysiology-guided, radioablation for ventricular tachycardia.We targeted arrhythmogenic scar regions by combining anatomical during tachycardia that was induced means an implantable cardioverter-defibrillator (ICD). SBRT simulation, planning, treatments...
Abstract Ventricular arrhythmias are an important cause of morbidity and mortality come in a variety forms, from single premature ventricular complexes to sustained tachycardia fibrillation. Rapid developments have taken place over the past decade our understanding these ability diagnose treat them. The field catheter ablation has progressed with development new methods tools, publication large clinical trials. Therefore, global cardiac electrophysiology professional societies undertook...
Case studies have suggested the efficacy of catheter-free, electrophysiology-guided noninvasive cardiac radioablation for ventricular tachycardia (VT) using stereotactic body radiation therapy, although prospective data are lacking.We conducted a phase I/II trial in adults with treatment-refractory episodes VT or cardiomyopathy related to premature contractions (PVCs). Arrhythmogenic scar regions were targeted by combining anatomic and electric imaging standard therapy workflow followed...
Background— Various mechanisms of atrial fibrillation (AF) have been demonstrated experimentally. Invasive methods to study these in humans limitations, precluding continuous mapping both atria with sufficient resolution. In this article, we present biatrial epicardial activation sequences AF using noninvasive electrocardiographic imaging (ECGI). Methods and Results— the testing phase, ECGI accuracy was evaluated by comparing coregistered CARTO images during pacing 6 patients. Additionally,...
Abstract Cardiac radiotherapy (RT) may be effective in treating heart failure (HF) patients with refractory ventricular tachycardia (VT). The previously proposed mechanism of radiation-induced fibrosis does not explain the rapidity and magnitude which VT reduction occurs clinically. Here, we demonstrate hearts from RT that radiation achieve transmural within timeframe reduction. Electrophysiologic assessment irradiated murine reveals a persistent supraphysiologic electrical phenotype,...
The rapid heartbeat of ventricular tachycardia (VT) can lead to sudden cardiac death and is a major health issue worldwide. Efforts identify patients at risk, determine mechanisms VT, effectively prevent treat VT through mechanism-based approach would all be facilitated by continuous, noninvasive imaging the arrhythmia over entire heart. Here, we present real-time images human arrhythmias using electrocardiographic (ECGI). Our results reveal diverse activation patterns, mechanisms, sites...
Background— Brugada syndrome (BrS) is a highly arrhythmogenic cardiac disorder, associated with an increased incidence of sudden death. Its substrate in the intact human heart remains ill-defined. Methods and Results— Using noninvasive ECG imaging, we studied 25 BrS patients to characterize electrophysiological 6 right bundle-branch block for comparison. Seven healthy subjects provided control data. Abnormal was observed exclusively ventricular outflow tract following properties (in...
Introduction: Chronic kidney disease (CKD) has been independently associated with increased cardiovascular mortality. Little is known about the benefit of implantable cardioverter defibrillator (ICD) therapy for prevention sudden death in this large, high‐risk population. We sought to evaluate impact CKD on survival patients who received an ICD primary death. Methods and Results: In retrospective study underwent implantation death, were stratified by CKD, defined as serum creatinine ≥2 mg/dL...
Background— Phase analysis of cardiac arrhythmias, particularly atrial fibrillation, has gained interest because the ability to detect organized stable drivers (rotors) and target them for therapy. However, lack methodology details in publications on topic resulted ongoing debate over phase mapping technique. By comparing maps activation maps, we examined advantages limitations mapping. Methods Results— Seven subjects were enrolled. We generated from electrocardiographic...
Abstract Ventricular arrhythmias are an important cause of morbidity and mortality come in a variety forms, from single premature ventricular complexes to sustained tachycardia fibrillation. Rapid developments have taken place over the past decade our understanding these ability diagnose treat them. The field catheter ablation has progressed with development new methods tools, publication large clinical trials. Therefore, global cardiac electrophysiology professional societies undertook...
Background Options for patients with ventricular tachycardia (VT) refractory to antiarrhythmic drugs and/or catheter ablation remain limited. Stereotactic radiotherapy has been described as a novel treatment option. Methods Seven recurrent VT, deemed high risk either first time or redo invasive ablation, were treated across three UK centres non-invasive cardiac stereotactic ablative (SABR). Prior data and mapping combined cross-sectional imaging generate plans aim deliver single 25 Gy...
Worldwide, 10% of babies are born preterm, defined as a live birth before 37 weeks gestation. Preterm is the leading cause neonatal death, and survivors face lifelong risks adverse outcomes. New approaches with large sample sizes needed to identify strategies predict prevent preterm birth. The primary aims Washington University Prematurity Research Cohort Study were conduct three prospective projects addressing possible causes provide data samples for future research. Pregnant patients...
Ischemic cardiomyopathy (ICM) can provide the substrate for ventricular tachycardia (VT).To map noninvasively with high resolution electrophysiologic (EP) scar substrate, identify its relationship to reentry circuits during VT, and stratify VT risk in ICM patients.Noninvasive high-resolution epicardial mapping electrocardiographic imaging (ECGI) was performed 32 patients (17 clinical 15 without VT). Abnormal EP determined based on electrogram (EGM) amplitude (as percentage of maximal...
Ventricular arrhythmias are an important cause of morbidity and mortality come in a variety forms, from single premature ventricular complexes to sustained tachycardia fibrillation. Rapid developments have taken place over the past decade our understanding these ability diagnose treat them. The field catheter ablation has progressed with development new methods tools, publication large clinical trials. Therefore, global cardiac electrophysiology professional societies undertook outline...