A5025712547- MRI in cancer diagnosis
- Advanced MRI Techniques and Applications
- Pregnancy and preeclampsia studies
- Climate variability and models
- Fetal and Pediatric Neurological Disorders
- Physics of Superconductivity and Magnetism
- Radiomics and Machine Learning in Medical Imaging
- Meteorological Phenomena and Simulations
- Medical Imaging Techniques and Applications
- Birth, Development, and Health
- Lanthanide and Transition Metal Complexes
- Gestational Diabetes Research and Management
- Advanced Condensed Matter Physics
- Epigenetics and DNA Methylation
- Maternal and fetal healthcare
- Atmospheric Ozone and Climate
- Cancer, Hypoxia, and Metabolism
- Prenatal Substance Exposure Effects
- Neonatal and fetal brain pathology
- Histone Deacetylase Inhibitors Research
- Atomic and Subatomic Physics Research
- Advanced Neuroimaging Techniques and Applications
- Advanced Chemical Physics Studies
- Glioma Diagnosis and Treatment
- Electron and X-Ray Spectroscopy Techniques
Advanced Imaging Research (United States)
2015-2025
Oregon Health & Science University
2016-2025
University of Utah
2009-2024
Huntsman Cancer Institute
2010-2017
University of Arizona
2017
University of Alabama at Birmingham
2013
Fujita Health University Hospital
2013
Inserm
2013
Sorbonne Université
2013
Institut du Cerveau
2013
Abstract Zika virus (ZIKV) infection during pregnancy leads to an increased risk of fetal growth restriction and central nervous system malformations, which are outcomes broadly referred as the Congenital Syndrome (CZS). Here we infect pregnant rhesus macaques investigate impact persistent ZIKV on uteroplacental pathology, blood flow, development. Despite seemingly normal fetal-placenta-maternal infection, advanced non-invasive in vivo imaging studies reveal dramatic effects placental oxygen...
Over the period from 1979 to 2001, tropospheric trends derived a widely cited analysis of Microwave Sounding Unit (MSU) temperature record show little or no warming, while surface based on in situ observations pronounced warming ∼0.2 K decade−1. This discrepancy between at and upper atmosphere has been source significant debate. Model predictions amplification with height troposphere are clearly inconsistent available observations, leading some researchers question adequacy their...
Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a widely used technique for assessing tissue physiology. Spoiled gradient echo (SPGR) pulse sequences are one of the most common methods acquisition DCE-MRI data, providing high temporal and spatial resolution with strong T1-weighting. Conversion SPGR signal to concentration briefly reviewed, new closed-form expression measurement uncertainty finite signal-to-noise ratio (SNR) baseline scan time derived. This result applicable...
Results of an ab initio density-functional study interlayer binding in graphite are presented. We obtain good agreement with experimental results for the equilibrium c-axis lattice parameter, exfoliation energy, and uniaxial compressibility this highly anisotropic material. also present calculated band structure graphite.
Measures of tumor vascularity and hypoxia have been correlated with glioma grade outcome. Dynamic contrast-enhanced (DCE) MRI can noninvasively map blood flow, vascularity, permeability. In this prospective observational cohort pilot study, preoperative imaging was molecular markers hypoxia, proliferation, progression-free overall patient survival. Pharmacokinetic modeling methods were used to generate maps extraction fraction, permeability-surface area product, transfer constant, washout...
Angle-resolved photoemission studies of the dispersion relations and polarization dependence bands in near ${E}_{F}$ region untwinned ${\mathrm{YBa}}_{2}{\mathrm{Cu}}_{3}{\mathrm{O}}_{7\ensuremath{-}\ensuremath{\delta}}$ (Y123) single crystals reveal previously unseen details electronic structure significantly expand our understanding this system. We find that narrow, intense feature seen along $\ensuremath{\Gamma}Y$ Y123 ${\mathrm{YBa}}_{2}{\mathrm{Cu}}_{4}{\mathrm{O}}_{8}$ (Y124) is best...
The atomic structures of the low-coverage 2\ifmmode\times\else\texttimes\fi{}2 phases Al, Ga, and In on Si(100) were determined basis first-principles total-energy calculations angle-resolved photoemission experiments. proposed structure consists rows ad-dimers, with ad-dimers oriented parallel to underlying Si dimers. Angle-resolved experiments performed for Si(100)2\ifmmode\times\else\texttimes\fi{}2:ln are in good agreement calculated surface-state dispersions ad-dimer model. existence...
To determine the extent to which gadolinium chelate is found in nonhuman primate fetal tissues and amniotic fluid at 19-45 hours after intravenous injection of a weight-appropriate maternal dose contrast agent gadoteridol.
We report angle-resolved photoemission spectroscopy measurements of the excitation gap in underdoped superconducting thin films Bi_2Sr_2Ca_{1-x}Dy_xCu_2O_{8+d}. As Tc is reduced by a factor 2 underdoping, state \Delta does not fall proportionally, but instead stays constant or increases slightly, violation BCS mean-field theory result. The different doping dependences and kT_c indicate that they represent energy scales. also show highly anisotropic consistent with d_{x^2-y^2} order...
There is no single reference dataset of long-term global upper-air temperature observations, although several groups have developed datasets from radiosonde and satellite observations for climate-monitoring purposes. The existence multiple data products allows exploration the uncertainty in signals climate variations change. This paper examines eight quantifies magnitude various signals, including stratospheric quasi-biennial oscillation (QBO) tropospheric ENSO warming following three major...
Propagation of errors, in conjunction with the theoretical signal equation for spoiled gradient echo pulse sequences, is used to derive a expression uncertainty quantitative variable flip angle T(1) mapping using two angles. This then minimized rigorous optimal angles that elucidates commonly empirical result. The expressions and are combined lower bound on achievable given set sequence parameters signal-to-noise ratio (SNR). These results provide means quantitatively determining effect...
Abstract A method to simultaneously estimate the arterial input function (AIF) and pharmacokinetic model parameters from dynamic contrast‐enhanced (DCE)‐MRI data was developed. This algorithm uses a parameterized functional form AIF k ‐means clustering classify tissue time‐concentration measurements into set of characteristic curves. An iterative blind estimation alternately estimated for model. Computer simulations were used investigate algorithm's sensitivity noise initial estimates. In 12...
Purpose The maternal microvasculature of the primate placenta is organized into 10–20 perfusion domains that are functionally optimized to facilitate nutrient exchange support fetal growth. This study describes a dynamic contrast‐enhanced magnetic resonance imaging method for identifying vascular and quantifying blood flow in them. Methods A rhesus macaque on 133rd day pregnancy (G133, term = 165 days) underwent Doppler ultrasound procedures, Cesarean‐section delivery. Serial T 1 ‐weighted...
To characterize spatial patterns of T2* in the placenta rhesus macaque (Macaca mulatta), to correlate these with placental perfusion determined using dynamic contrast-enhanced MRI (DCE-MRI), and evaluate potential for blood oxygen level-dependent effect quantify without use exogenous contrast reagent.MRI was performed on three pregnant macaques at gestational day 110. Multiecho spoiled gradient echo measurements were used compute maps T2*. Spatial maxima compared foci early enhancement by...
Existing methods for evaluating in vivo placental function fail to reliably detect pregnancies at-risk adverse outcomes prior maternal and/or fetal morbidity. Here we report the results of a prospective dual-site longitudinal clinical study quantitative T2* as measured by blood oxygen-level dependent magnetic resonance imaging (BOLD-MRI). The objectives this were: 1) quantify at multiple time points across gestation, and its consistency sites, 2) investigate association between outcomes. 797...
We present results of the first optical and angle-resolved photoemission study on a layered ruthenium oxide system with various Ca/Sr substitution levels. Using two-plane $({\mathrm{Sr}}_{1\ensuremath{-}x}{\mathrm{Ca}}_{x}{)}_{3}{\mathrm{Ru}}_{2}{\mathrm{O}}_{7}$ one-plane ${\mathrm{Ca}}_{2}{\mathrm{RuO}}_{4}$ crystals we were able to evolution electronic properties in range from band metal $({\mathrm{Sr}}_{3}{\mathrm{Ru}}_{2}{\mathrm{O}}_{7})$ ``bad''...
Two independent analyses of the same satellite-based radiative emissions data yield tropospheric temperature trends that differ by 0.1 degrees C per decade over 1979 to 2001. The troposphere warms appreciably in one satellite set, while other set shows little overall change. These uncertainties are important studies seeking identify human effects on climate. A model-predicted "fingerprint" combined anthropogenic and natural is statistically detectable only with a warming troposphere. Our...
Abstract Purpose To assess the accuracy of a model‐based approach for registration myocardial dynamic contrast‐enhanced (DCE)‐MRI corrupted by respiratory motion. Materials and Methods Ten patients were scanned perfusion on 3T or 1.5T scanners, short‐ long‐axis slices acquired. Interframe was done using an iterative method in conjunction with mean square difference metric. The tested comparing absolute motion before after registration, as determined from manually registered images. Regional...
Several methods of flip angle mapping for magnetic resonance imaging have been proposed. We evaluated the accuracy five measurement in presence noise. Our analysis was performed a closed form by propagation probability density functions (PDFs). The compared were (1) phase-sensitive method, (2) dual-angle method using gradient recalled echoes (GRE), (3) an extended version GRE incorporating phase information, (4) AFI and (5) information. took into account differences required time these...
We describe the gamma capillary transit time model, a generalized impulse response model for DCE-MRI that mathematically unifies Tofts-Kety, extended adiabatic tissue homogeneity, and two-compartment exchange models. By including parameter (α⁻¹) representing width of distribution times within voxel, GCTT discriminates tissues having relatively monodisperse distributions from those large degree heterogeneity. All five models were compared using in vivo data acquired three brain tumors (one...
Accurate quantification of pharmacokinetic model parameters in tracer kinetic imaging experiments requires correspondingly accurate determination the arterial input function (AIF). Despite significant effort expended on methods directly measuring patient-specific AIFs modalities as diverse dynamic contrast-enhanced magnetic resonance (DCE-MRI), positron emission tomography (PET), and perfusion computed (CT), fundamental technical difficulties have made consistent reliable achievement that...