A5088167436- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Vaccine Coverage and Hesitancy
- Long-Term Effects of COVID-19
- Animal Virus Infections Studies
- COVID-19 epidemiological studies
- vaccines and immunoinformatics approaches
- Immune Cell Function and Interaction
- Hepatitis B Virus Studies
- Mosquito-borne diseases and control
- Antifungal resistance and susceptibility
- Immunodeficiency and Autoimmune Disorders
- CRISPR and Genetic Engineering
- Hepatitis Viruses Studies and Epidemiology
- Pneumonia and Respiratory Infections
- Tuberculosis Research and Epidemiology
- Vitamin D Research Studies
- T-cell and B-cell Immunology
- Plant Virus Research Studies
- Heparin-Induced Thrombocytopenia and Thrombosis
- Respiratory viral infections research
- SARS-CoV-2 detection and testing
- interferon and immune responses
- Viral gastroenteritis research and epidemiology
- Poxvirus research and outbreaks
Abu Dhabi Health Services
2016-2025
Khalifa University of Science and Technology
2022-2025
Shaikh Khalifa Medical City
2012-2023
Centers for Disease Control and Prevention
2016
America Bangladesh University
2016
Children's Hospital of Eastern Ontario
2005-2006
<h3>Importance</h3> Although effective vaccines against COVID-19 have been developed, additional are still needed. <h3>Objective</h3> To evaluate the efficacy and adverse events of 2 inactivated vaccines. <h3>Design, Setting, Participants</h3> Prespecified interim analysis an ongoing randomized, double-blind, phase 3 trial in United Arab Emirates Bahrain among adults 18 years older without known history COVID-19. Study enrollment began on July 16, 2020. Data sets used for were locked...
Abstract To unravel the source of SARS-CoV-2 introduction and pattern its spreading evolution in United Arab Emirates, we conducted meta-transcriptome sequencing 1,067 nasopharyngeal swab samples collected between May 9th Jun 29th, 2020 during first peak local COVID-19 epidemic. We identified global clade distribution eleven novel genetic variants that were almost absent rest world defined five subclades specific to UAE viral population. Cross-settlement human-to-human transmission was...
COVID-19 vaccines have proven to be very safe in the clinical trials, however, there is less evidence comparing safety of these real-world settings. Therefore, we aim investigate nature and severity adverse effects reported differences based on type vaccine received. A survey was conducted among 1,878 adult (≥18 years) recipients through online platforms telephonic interviews during March September 2021. The factors potentially associated with side like age, gender, ethnicity, comorbidities,...
Middle East respiratory syndrome coronavirus (MERS-CoV) infections sharply increased in the Arabian Peninsula during spring 2014. In Abu Dhabi, United Arab Emirates, these occurred primarily among healthcare workers and patients. To identify describe epidemiologic clinical characteristics of persons with healthcare-associated infection, we reviewed laboratory-confirmed MERS-CoV cases reported to Health Authority Dhabi January 1, 2013-May 9, Of 65 case-patients identified 27 (42%) had cases....
An inherited disorder makes WAVEs The WAVE regulatory complex (WRC) is a multiunit that regulates actin cytoskeleton formation. Although other actin-regulatory proteins modulate human immune responses, the precise role for WRC has not yet been established. Cook et al. studied five patients from four unrelated families who harbor missense variants of gene encoding component HEM1. These presented with recurrent infections and poor antibody along enhanced allergic autoimmune disorders. HEM1 was...
Insufficient blood levels of the neurohormone vitamin D are associated with increased risk COVID-19 severity and mortality. Despite global rollout vaccinations promising preliminary results, focus remains on additional preventive measures to manage COVID-19. Results conflict D's plausible role in preventing treating We examined relation between status mortality among multiethnic population United Arab Emirates. Our observational study used data for 522 participants who tested positive...
The SARS-CoV-2 subvariant BA.2.86 ‘Pirola’, first identified in Denmark August 2023, has manifested with a significantly mutated spike protein profile, suggesting heightened ability to evade vaccine-induced and infection-induced antibodies. This article outlines the epidemiological spread, immune response implications, global responses BA.2.86. Preliminary observations indicate community transmissions of subvariant, even among those previously infected or vaccinated. Notably, infection shown...
Abstract NVSI-06-08 is a potential broad-spectrum recombinant COVID-19 vaccine that integrates the antigens from multiple SARS-CoV-2 strains into single immunogen. Here, we evaluate safety and immunogenicity of as heterologous booster dose in BBIBP-CorV recipients randomized, double-blind, controlled, phase 2 trial conducted United Arab Emirates (NCT05069129). Three groups healthy adults over 18 years age (600 participants per group) who have administered two doses 4-6-month, 7-9-month...
Abstract The effectiveness of the inactivated BBIBP-CorV vaccine against severe COVID-19 outcomes (hospitalization, critical care admission and death due to COVID-19) its long-term have not been well characterized among general population. We conducted a retrospective cohort study using electronic health records 3,147,869 adults, which 1,099,886 vaccinated individuals were matched, in 1:1 ratio unvaccinated persons. A Cox-proportional hazard model with time varying coefficients was used...
The heterogeneity in symptomatology and phenotypic profile attributable to COVID-19 is widely unknown. objective of this manuscript conduct a trans-ancestry genome wide association study (GWAS) meta-analysis severity improve the understanding potentially causal targets for SARS-CoV-2.This cross-sectional recruited 646 participants UAE that were divided into two groups based on phenotypes, hospitalized (n=482) non-hospitalized (n=164) participants. Hospitalized patients developed acute...
The increased coronavirus disease 2019 (COVID-19) breakthrough cases pose the need of booster vaccination. We conducted a randomised, double-blinded, controlled, phase 2 trial to assess immunogenicity and safety heterologous prime-boost vaccination with an inactivated COVID-19 vaccine (BBIBP-CorV) followed by recombinant protein-based (NVSI-06-07), using homologous boost BBIBP-CorV as control. Three groups healthy adults (600 individuals per group) who had completed two-dose vaccinations 1-3...
The interplay between the compositional changes in gastrointestinal microbiome, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) susceptibility and severity, host functions is complex yet to be fully understood. This study performed 16S rRNA gene-based microbial profiling of 143 subjects. We observed structural alterations gut microbiota SARS-CoV-2-infected group comparison non-infected controls. composition individuals showed an increase anti-inflammatory bacteria such as...
The United Arab Emirates (UAE) was the first country in Middle East to report severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Serosurveys are essential understanding extent of virus transmission. This cross-sectional study aims assess seroprevalence SARS-CoV-2 infection Emirate Abu Dhabi.Between 19 July and 14 August 2020, 4487 households were selected using a random sample stratified by region citizenship head household (UAE citizen or non-citizen). A cluster 40...
Tuberculosis (TB) remains a significant global health concern. Although the Gulf Cooperation Council (GCC) countries have relatively lower TB incidence rates, they face unique challenges, particularly with large migrant workforce from TB-endemic regions. Understanding trends in burden these is essential for guiding public strategies. We analyzed GCC 1990 to 2021 using data Global Burden of Disease (GBD) study. Joinpoint regression assessed temporal trends, and ARIMA modeling was used...
To unravel the source of SARS-CoV-2 introduction and pattern its spreading evolution in United Arab Emirates, we conducted meta-transcriptome sequencing 1067 nasopharyngeal swab samples collected between May 9th Jun 29th, 2020 during first peak local COVID-19 epidemic. We identified global clade distribution eleven novel genetic variants that were almost absent rest world defined five subclades specific to UAE viral population. Cross-settlement human-to-human transmission was related...
Vitamin D has many effects on cells in the immune system. Many studies have linked low vitamin status with severity of COVID-19. Genetic variants involved metabolism been implicated as potential risk factors for severe COVID-19 outcomes. This study investigated how genetic variations humans affected clinical presentation In total, 646 patients SARS-CoV-2 infection were divided into two groups: noncritical (
Abstract Based on the findings from Phase III clinical trials of inactivated SARS COV-2 Vaccine, (BBIBP-CORV) emergency use authorization (EUA) was granted for vaccine to frontline workers in UAE. A prospective cohort study conducted among estimate incidence rate and risk symptomatic COVID-19 infection 14 days after second dose inoculation with BBIBP-CORV vaccine. Those who received two doses period 14th September 2020 (first dose) 21st December (second were followed up infections. 11,322...
The study aims to explore the risk factors, clinical characteristics, and outcomes of mpox infection in Abu Dhabi, United Arab Emirates (UAE).