A5080336061- Influenza Virus Research Studies
- Respiratory viral infections research
- Immune Response and Inflammation
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Viral Infectious Diseases and Gene Expression in Insects
- Virus-based gene therapy research
- Immune Cell Function and Interaction
- Gallbladder and Bile Duct Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Hepatitis B Virus Studies
- Customer Service Quality and Loyalty
- vaccines and immunoinformatics approaches
- Animal Virus Infections Studies
- Viral Infections and Outbreaks Research
- CAR-T cell therapy research
- Elbow and Forearm Trauma Treatment
- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- Long-Term Effects of COVID-19
- Viral gastroenteritis research and epidemiology
- interferon and immune responses
- Esophageal and GI Pathology
University of Oxford
2024
Medical Research Council
2024
China National Biotechnology (China)
2018-2023
Wuhan University
2023
Renmin Hospital of Wuhan University
2023
Ruijin Hospital
2023
University of Washington
2020
National Vaccine and Serum Institute
2020
International Peace Maternity & Child Health Hospital
2020
Shanghai Jiao Tong University
2006-2020
Currently, there are no approved specific antiviral agents for novel coronavirus disease 2019 (COVID-19). In this study, 10 severe patients confirmed by real-time viral RNA test were enrolled prospectively. One dose of 200 mL convalescent plasma (CP) derived from recently recovered donors with the neutralizing antibody titers above 1:640 was transfused to as an addition maximal supportive care and agents. The primary endpoint safety CP transfusion. second endpoints improvement clinical...
Abstract Currently, there are no approved specific antiviral agents for 2019 novel coronavirus disease (COVID-19). In this study, ten severe patients confirmed by real-time viral RNA test were enrolled prospectively. One dose of 200 mL convalescent plasma (CP) derived from recently recovered donors with the neutralizing antibody titers above 1:640 was transfused to as an addition maximal supportive care and agents. The primary endpoint safety CP transfusion. second endpoints improvement...
Seasonal influenza, causes hundreds of thousands deaths annually, posing a severe threat to human health. Currently available influenza vaccines are targeted only at specific strains or conserved epitopes; however, these not completely efficacious because viruses can undergo mutation during circulation, leading antigenic mismatch between recommended and circulating elusion from the immune system. Therefore, developing an vaccine that is quick, effective, broadly protective has become...
Since May 2022, human mpox cases have increased unexpectedly in non-endemic countries. The first imported case of Hong Kong was reported September 2022. Here we report the isolation and identification MPXV from vesicle swabs this patient. In research, were inoculated Vero E6 cells. addition to observing cytopathic effects (CPEs) or cells, isolated virus identified as (MPXV) using quantitative Real-Time PCR (RT-PCR), transmission electron microscopy, high-throughput sequencing. experiment...
Abstract Based on the findings from Phase III clinical trials of inactivated SARS COV-2 Vaccine, (BBIBP-CORV) emergency use authorization (EUA) was granted for vaccine to frontline workers in UAE. A prospective cohort study conducted among estimate incidence rate and risk symptomatic COVID-19 infection 14 days after second dose inoculation with BBIBP-CORV vaccine. Those who received two doses period 14th September 2020 (first dose) 21st December (second were followed up infections. 11,322...
Lowering low-density lipoprotein cholesterol (LDL-C) through PCSK9 inhibition represents a new therapeutic approach to preventing and treating cardiovascular disease (CVD). Phenome-wide analyses of genetic variants in large biobanks can help identify unexpected effects inhibition. In the prospective China Kadoorie Biobank, we constructed score using three at locus associated with directly measured LDL-C [PCSK9 (PCSK9-GS)]. Logistic regression gave estimated odds ratios (ORs) for PCSK9-GS...
For pilot-scale manufacturing of hemoglobin-based oxygen carrying drugs, we should get highly pure and viral inactivated hemoglobin (Hb) at high recovery. In our method, placenta (PHb) solutions were purified by heating in the presence reducing agent deoxygenating conditions so that heat-sensitive proteins selectively precipitated virus was inactivated. The optimum preparative condition resulted PHb solution (>99% pure) with approximate 90% recovery less than 2% MetHb content, maintained...
Poor immune responses to inactivated influenza vaccine can be improved by effective and safe adjuvants increase antibody titers cellular protective response. In our study, AddaVax PolyI:C combined adjuvant (AP adjuvant) were used for development. After immunizing BALB/c mice Wistar rats intramuscularly, Split H3N2 adjuvanted with AP elicited higher serum hemagglutination-inhibition antibodies IgG titers. We demonstrated that induced a transient innate cytokines production at the injection...
This phase III clinical trial aimed to assess the safety and demonstrate immunogenicity of a candidate freeze-dried purified Vero cell-based rabies vaccine (PVRV-WIBP) developed for human use. A cohort 40 participants in stage 1 1956 subjects 2 with an age range 10–50 years were recruited trial. For analysis 1, 20 received either 4-dose or 5-dose regimen PVRV-WIBP. In 2, randomly divided into PVRV-WIBP, PVRV-LNCD, PVRV-WIBP groups. The serum neutralizing antibody titer against was determined...
Background A quadrivalent split influenza vaccine IIV4-W against both and B viruses is urgently needed.Methods To evaluate the safety immunogenicity of in people aged 3–60 years, 2400 participants recruited a double-blind phase III trial were randomly assigned to IIV4-W, TIV1 TIV2 groups. The indicators measured at 28 days postvaccination for 180 follow-up.Results Adverse events (AEs) occurred 162 (20.28%), 116 (14.55%) 123 (15.41%) groups, respectively. All these AEs mild self-limiting, no...
Abstract Nucleic acid drugs can treat diseases caused by defective or abnormal genes. Herein, the mechanism of non‐viral vectors for nucleic drug delivery is described. This review introduce delivery, including acid‐carrier conjugate, proteins and peptides‐based nanoparticles, polysaccharides, other biological macromolecules‐based nanoparticles consisting lipid synthetic polymers‐based inorganic organic–inorganic hybrid nanoparticles. Finally, challenges prospects are discussed.
To control seasonal influenza epidemics in elders, a quadrivalent, inactivated, split-virion vaccine (IIV4) comprising A and B lineages is produced for young individuals adults aged ≥60 years. In this phase III, randomized, double-blind, active-controlled trial, we compared safety immunogenicity of IIV4 with licensed quadrivalent inactivated (IIV4-HL) by Hualan Biological Engineering during the 2019 season. Participants were randomly assigned to receive (n = 959) or IIV4-HL 959). Compared...
Insights into the potential candidate hub genes may facilitate generation of safe and effective immunity against seasonal influenza as well development personalized vaccines for elderly at high risk virus infection. This study aimed to identify related immune induction process 2018/19 quadrivalent inactivated (QIVs) in ≥60 years by using weighted gene co-expression network analysis (WGCNA). From 63 whole blood samples from16 individuals, a total 13,345 were obtained divided eight modules,...
In influenza vaccine development, Madin-Darby canine kidney (MDCK) cells provide multiple advantages, including large-scale production and egg independence. Several cell-based vaccines have been approved worldwide. We cultured H5N1 virus in a serum-free MDCK cell suspension. The harvested was manufactured into after inactivation purification. effectiveness assessed the Wuhan Institute of Biological Products BSL2 facility. pre- postvaccination mouse serum titers were determined using...