A5067072586- Air Quality and Health Impacts
- Climate Change and Health Impacts
- Energy and Environment Impacts
- Monoclonal and Polyclonal Antibodies Research
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Air Quality Monitoring and Forecasting
- CAR-T cell therapy research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- T-cell and B-cell Immunology
- Birth, Development, and Health
- Chemical Synthesis and Analysis
- Pregnancy and preeclampsia studies
- Chemical Synthesis and Reactions
- Bacterial Genetics and Biotechnology
- Global Health Care Issues
- Occupational and environmental lung diseases
- Obesity, Physical Activity, Diet
- vaccines and immunoinformatics approaches
- Synthetic Organic Chemistry Methods
- Health disparities and outcomes
- Gestational Diabetes Research and Management
- Sleep and related disorders
- Management of metastatic bone disease
- Global Maternal and Child Health
University of Oxford
2016-2025
Midwestern University
2025
Genocea (United States)
2018-2023
L'Oreal (United States)
2021
Hong Kong Polytechnic University
2021
Nuffield Health
2019
MRC Epidemiology Unit
2017
MRC Population Health Research Unit
2017
University of Birmingham
2009-2016
Sanofi (United States)
2013-2016
Anyone for d ? The chemistry of amino acids comes in two chirally distinct flavors—so-called l - and -enantiomers. By far the most commonly used form all kingdoms life is -form. Now Lam et al. (p. 1552 ; see Perspective by Blanke ) present unanticipated observation that diverse bacteria release large amounts various -amino into environment a population density–dependent fashion act as extracellular effectors regulate composition, structure, amount, strength peptidoglycan, major...
<h3>Importance</h3> When combusted indoors, solid fuels generate a large amount of pollutants such as fine particulate matter. <h3>Objective</h3> To assess the associations fuel use for cooking and heating with cardiovascular all-cause mortality. <h3>Design, Setting, Participants</h3> This nationwide prospective cohort study recruited participants from 5 rural areas across China between June 2004 July 2008; mortality follow-up was until January 1, 2014. A total 271 217 adults without...
Abstract Background: Few studies have assessed long-term effects of particulate matter (PM) with aerodynamic diameter &lt; 2.5 μm (PM2.5) on mortality for causes cancer other than the lung; we multiple causes. In Hong Kong, most people live and work in urban or suburban areas high-rise buildings. This facilitates estimation PM2.5 exposure individuals, taking into account height residence above ground level assessment health sufficient statistical power. Methods: We recruited 66,820...
Tobacco smoking is estimated to account for more than 1 million annual deaths in China, and the epidemic continues increase men. Large nationwide prospective studies linked different health records can help periodically assess disease burden attributed smoking. We aimed examine associations of with incidence mortality from an extensive range diseases China.We analysed data China Kadoorie Biobank, which recruited 512 726 adults aged 30-79 years, whom 210 201 were men 302 525 women....
Abstract Alcohol consumption accounts for ~3 million annual deaths worldwide, but uncertainty persists about its relationships with many diseases. We investigated the associations of alcohol 207 diseases in 12-year China Kadoorie Biobank >512,000 adults (41% men), including 168,050 genotyped ALDH2 - rs671 and ADH1B rs1229984 , >1.1 ICD-10 coded hospitalized events. At baseline, 33% men drank regularly. Among men, intake was positively associated 61 diseases, 33 not defined by World...
Summary The tubulin homologue FtsZ is well known for its essential function in bacterial cell division. Here, we show that Caulobacter crescentus , also plays a major role elongation by spatially regulating the location of MurG, which produces lipid II peptidoglycan wall precursor. early assembly into highly mobile ring‐like structure during quickly followed recruitment MurG and redirection precursor synthesis to midcell region. These FtsZ‐dependent events occur before constriction...
Over half the world's population, mostly from developing countries, use solid fuel for domestic purposes and are exposed to very high concentrations of harmful air pollutants with potential health effects such as respiratory problems, cardiovascular infant mortality ocular problems. The evidence also suggests that, although total percentage people using is decreasing, absolute number currently increasing. Exposure smoke burning increases risk chronic obstructive pulmonary disease (COPD) lung...
A limited number of studies on long-term effects particulate matter with aerodynamic diameter < 2.5 μm (PM2.5) health suggest it can be an important cause morbidity and mortality. In Asia where air quality is poor deteriorating, local data PM2.5 to support policy management are scarce. We assessed the mortality in a single Asian city. For 10-13 years, we followed up cohort 66,820 participants ≥ 65 years age who were enrolled interviewed all 18 Elderly Health Centres Department Health, Hong...
Psychological health amongst healthcare workers (HCWs) has become a major concern since the COVID-19 outbreak. HCWs perceived risks of contracting COVID-19, in relation to depression were investigated. It was hypothesised that high risk (close contact with cases, inadequate provision personal protective equipment, insufficient infection control training, and presence symptoms) would be significant predictors depression. Our cross-sectional survey completed by across three regions (Hubei,...
In network theory depression is conceptualized as a complex of individual symptoms that influence each other, and central in the have greatest impact on other symptoms. Clinical features are largely determined by sociocultural context. No previous study examined structure depressive Hong Kong residents. The aim this was to characterize symptom community adult sample during COVID-19 pandemic. A total 11,072 participants were recruited between 24 March 20 April 2020. Depressive measured using...
Few cohort studies explored the long-term effects of ambient fine particulate matter (PM2.5) on incidence cardiovascular diseases (CVDs), especially in countries with higher levels air pollution. We aimed to evaluate association between exposure PM2.5 and CVD China. performed a prospective study ten regions that recruited 512,689 adults during 2004–2008, follow-up until 2017. Annual concentrations were estimated using satellite-based model national coverage 1 x km spatial resolution....
Abstract Background Existing evidence on long-term ambient air pollution (AAP) exposure and risk of cardio-respiratory diseases in China is mainly mortality, based area average concentrations from fixed-site monitors for individual exposures. Substantial uncertainty persists, therefore, about the shape strength relationship when assessed using more personalised data. We aimed to examine relationships between AAP predicted local levels AAP. Methods A prospective study included 50,407...
There is some evidence that chronic obstructive pulmonary disease (COPD) and metabolic syndrome may be related, perhaps through systemic inflammation, which common to both. However, the association between two conditions has not yet been clearly shown. The present study involved 7,358 adults aged ≥50 yrs from a population-based survey who underwent spirometry, structured interview measurement of fasting marker levels. Airflow obstruction (forced expiratory volume in 1 s/forced vital capacity...
Intentional napping is very common, particularly in China. However, there are limited data regarding its potential health effects. We therefore examined the possible relationship between and type 2 diabetes. Cross-sectional analysis of baseline from Guangzhou Biobank Cohort Study. Community-based elderly association Guangzhou, 19,567 Chinese men women aged 50 years or older. Self-reported frequency was obtained by questionnaire diabetes assessed fasting blood glucose and/or self-reports...