Dan Schmidt
A5035272369- Genetic Associations and Epidemiology
- Cardiovascular Health and Risk Factors
- Air Quality and Health Impacts
- Nutritional Studies and Diet
- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- Energy and Environment Impacts
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Disease and Adiposity
- Climate Change and Health Impacts
- Acute Ischemic Stroke Management
- Lipoproteins and Cardiovascular Health
- Cardiovascular Function and Risk Factors
- Birth, Development, and Health
- Diet, Metabolism, and Disease
- Metabolomics and Mass Spectrometry Studies
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer-related molecular mechanisms research
- Folate and B Vitamins Research
- Cardiovascular Health and Disease Prevention
- Cancer Risks and Factors
- Obesity, Physical Activity, Diet
- Intracerebral and Subarachnoid Hemorrhage Research
- Advanced Proteomics Techniques and Applications
University of Oxford
2019-2025
Medical Research Council
2023-2025
The Coordinating Center
2018
Qingdao Municipal Center for Disease Control and Prevention
2018
Schmid (Germany)
2017
University of Wisconsin–Oshkosh
2001-2016
Universitäres Kinderwunschzentrum Lübeck
2012
University Hospital Schleswig-Holstein
2012
University of Lübeck
2012
Appalachian State University
2001
BackgroundStroke is a leading cause of death and disability worldwide. Despite considerable improvements in diagnosis treatment, little known about the short-term long-term prognosis after first stroke low-income middle-income countries, including China. We aimed to assess risk recurrent mortality for each major pathological types.MethodsThis population-based cohort study included adults aged 35–74 years without who were recruited China Kadoorie Biobank (CKB). A baseline survey was conducted...
Adherence to a combination of healthy lifestyle factors has been related considerable reduction cardiovascular risk in white populations; however, little is known whether such associations persist nonwhite populations like the Asian population.
Tobacco smoking is estimated to account for more than 1 million annual deaths in China, and the epidemic continues increase men. Large nationwide prospective studies linked different health records can help periodically assess disease burden attributed smoking. We aimed examine associations of with incidence mortality from an extensive range diseases China.We analysed data China Kadoorie Biobank, which recruited 512 726 adults aged 30-79 years, whom 210 201 were men 302 525 women....
Abstract Alcohol consumption accounts for ~3 million annual deaths worldwide, but uncertainty persists about its relationships with many diseases. We investigated the associations of alcohol 207 diseases in 12-year China Kadoorie Biobank >512,000 adults (41% men), including 168,050 genotyped ALDH2 - rs671 and ADH1B rs1229984 , >1.1 ICD-10 coded hospitalized events. At baseline, 33% men drank regularly. Among men, intake was positively associated 61 diseases, 33 not defined by World...
BackgroundThe age-specific association between blood pressure and vascular disease has been studied mostly in high-income countries, before the widespread use of brain imaging for diagnosis main stroke types (ischaemic intracerebral haemorrhage). We aimed to investigate this relationship among adults China.Methods512 891 (59% women) aged 30–79 years were recruited into a prospective study from ten areas China June 25, 2004, July 15, 2008. Participants attended assessment centres where they...
BackgroundCooking practice has transitioned from use of solid fuels to clean fuels, with addition better ventilation facilities. However, the change in mortality risk associated such a transition remains unclear.MethodsThe China Kadoorie Biobank (CKB) Study enrolled participants (aged 30–79 years) ten areas across China; we chose study five urban where for cooking was prevalent. Participants who reported regular (weekly or more frequently) at baseline were categorised as persistent fuel...
Breastfeeding confers substantial benefits to child health and has also been associated with lower risk of maternal cardiovascular diseases (CVDs) in later life. However, the evidence on effects CVD is still inconsistent, especially East Asians, whom frequency duration breastfeeding significantly differ from those West.In 2004-2008, nationwide China Kadoorie Biobank recruited 0.5 million individuals aged 30 79 years 10 diverse regions across China. During 8 follow-up, 16 671 incident cases...
BackgroundGenetic variants that affect alcohol use in East Asian populations could help assess the causal effects of consumption on cause-specific mortality. We aimed to investigate associations between intake and mortality using conventional genetic epidemiological methods among more than 512 000 adults China.MethodsThe prospective China Kadoorie Biobank cohort study enrolled 724 (210 205 men 302 519 women) aged 30–79 years, during 2004–08. Residents with no major disabilities from ten...
Integrated analyses of plasma proteomic and genetic markers in prospective studies can clarify the causal relevance proteins discover novel targets for ischemic heart disease (IHD) other diseases.
Integrated analyses of plasma proteomics and genetic data in prospective studies can help assess the causal relevance proteins, improve risk prediction, discover novel protein drug targets for type 2 diabetes (T2D).
BackgroundIn developed countries, smoking is associated with increased risk of diabetes. Little known about the association in China, where cigarette consumption has (first urban, then rural areas) relatively recently. Moreover, uncertainty remains effect cessation on diabetes China and elsewhere. We aimed to assess associations incident among Chinese adults.MethodsThe prospective Kadoorie Biobank enrolled 512 891 adults (59% women) aged 30–79 years during 2004–08 from ten diverse areas...
China has high stroke rates despite the population being relatively lean. Uncertainty persists about relevance of adiposity to risk types. We aimed assess associations with incidence types and effect mediation by blood pressure in Chinese men women.The Kadoorie Biobank enrolled 512 891 adults aged 30-79 years from ten areas (five urban five rural) during 2004-08. During a median 9 (IQR 8-10) follow-up, 32 448 strokes (about 90% confirmed neuroimaging) were recorded among 489 301 participants...
Little evidence from large-scale cohort studies exists about the relationship of solid fuel use with hospitalization and mortality major respiratory diseases.To examine associations risks acute chronic diseases.A study 277,838 Chinese never-smokers no prior diseases at baseline. During 9 years follow-up, 19,823 first episodes or deaths diseases, including 10,553 lower disease (CLRD), 4,398 obstructive pulmonary (COPD), 7,324 infection (ALRI), were recorded. Cox regression yielded adjusted...
Abstract Background Previous studies of primarily Western populations have reported contrasting associations dairy consumption with certain cancers, including a positive association prostate cancer and inverse colorectal premenopausal breast cancers. However, there are limited data from China where rates levels differ importantly those in populations. Methods The prospective Kadoorie Biobank study recruited ~0.5 million adults ten diverse (five urban, five rural) areas across during...
DNA methylation clocks emerged as a tool to determine biological aging and have been related mortality age-related diseases. Little is known about the association of age (DNAm age) with coronary heart disease (CHD), especially in Asian population.
In observational studies, type 2 diabetes is associated with two- to fourfold higher risk of cardiovascular diseases (CVD). Using data from the China Kadoorie Biobank (CKB), we examined associations genetically predicted CVD among ∼160,000 participants assess whether these relationships are causal. A genetic score (comprising 48 established variants) was presence carotid plaque (odds ratio 1.17 [95% CI 1.05, 1.29] per 1 unit log-odds diabetes; n = 6,819) and elevated ischemic stroke (IS)...
OBJECTIVE To assess prospective associations of circulating metabolites with the risk type 2 diabetes (T2D) among Chinese adults. RESEARCH DESIGN AND METHODS A case-cohort study within 8-year China Kadoorie Biobank comprised 882 participants incident T2D and 789 subcohort participants. Nuclear magnetic resonance metabolomic profiling quantified 225 in stored baseline plasma samples. Cox regression related individual risk, adjusting for potential confounders fasting time. RESULTS After...
Abstract Background Little is known about the effects of maintaining healthy sleep patterns on frailty transitions. Methods Based 23,847 Chinese adults aged 30–79 in a prospective cohort study, we examined associations between and Healthy included duration at 7 or 8 h/d, without insomnia disorder, no snoring. Participants who persisted with pattern both surveys were defined as scored one point. We used 27 phenotypes to construct index three statuses: robust, prefrail, frail. Frailty...
Abstract Background The relevance of folic acid for stroke prevention in low-folate populations such as China is uncertain. Genetic studies the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism, which increases plasma homocysteine (tHcy) levels, could clarify causal elevated tHcy levels stroke, ischaemic heart disease (IHD) and other diseases without fortification. Methods In prospective Kadoorie Biobank, 156 253 participants were genotyped MTHFR 12 240 developed a during...
Previous studies of the health impact ambient and household air pollution (AAP/HAP) have chiefly relied on self-reported and/or address-based exposure modelling data. We assessed feasibility collecting integrating detailed personal data in different settings seasons. recruited 477 participants (mean age 58 years, 72% women) from three (two rural [Gansu/Henan] one urban [Suzhou]) study areas China Kadoorie Biobank, based their previously reported fuel use patterns. A time-resolved monitor...
Abstract Background The association of incident cardiometabolic multimorbidity (CMM) with mortality risk is rarely studied, and neither are the durations diseases (CMDs). Whether patterns CMD change as individuals progress from one to CMM unclear. Methods Data China Kadoorie Biobank 512,720 participants aged 30–79 was used. defined simultaneous presence two or more CMDs interest, including diabetes, ischemic heart disease, stroke. Cox regression used estimate hazard ratios (HRs) 95%...
Abstract Adiposity is associated with multiple diseases and traits, but little known about the causal relevance mechanisms underlying these associations. Large-scale proteomic profiling, especially when integrated genetic data, can clarify linking adiposity disease outcomes. We examined associations of plasma levels 1463 proteins in 3977 Chinese adults, using measured genetically-instrumented BMI. further used two-sample bi-directional MR analyses to assess if certain influenced adiposity,...
BackgroundHospitals in China are classified into tiers (1, 2 or 3), with the largest (tier 3) having more equipment and specialist staff. Differential health insurance cost-sharing by hospital tier (lower deductibles higher reimbursement rates lower tiers) was introduced to reduce overcrowding hospitals, promote use of limit escalating healthcare costs. However, little is known about effects differential schemes on choice tiers.MethodsIn a 9-year follow-up prospective study 0.5 M adults from...
Background: Monitoring bone mineral density (BMD) in adults is critical for early detection of osteoporosis and prevention fracture, which quantitative ultrasound (QUS) a good non-invasive tool. We examined the associations QUS measures, including stiffness index (SI) T-score, with socio-demographic, lifestyle, anthropometric correlates risk subsequent fracture. Methods: Calcaneal was performed using GE's Lunar Achilles EXPII among 24,651 (mean age 59.5 years, 61.7% women) from China...