Ruth Boxall
A5064965502- Genetic Associations and Epidemiology
- Lipoproteins and Cardiovascular Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Nutritional Studies and Diet
- Birth, Development, and Health
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiovascular Health and Risk Factors
- Cardiovascular Disease and Adiposity
- Metabolomics and Mass Spectrometry Studies
- Acute Ischemic Stroke Management
- Cancer, Lipids, and Metabolism
- Climate Change and Health Impacts
- Cancer Risks and Factors
- Air Quality and Health Impacts
- Cardiovascular Health and Disease Prevention
- Cardiovascular Function and Risk Factors
- Diet and metabolism studies
- Global Public Health Policies and Epidemiology
- Asthma and respiratory diseases
- Health disparities and outcomes
- Adipokines, Inflammation, and Metabolic Diseases
- Epigenetics and DNA Methylation
- Nutrition, Genetics, and Disease
- Blood Pressure and Hypertension Studies
- Atherosclerosis and Cardiovascular Diseases
Medical Research Council
2017-2024
University of Oxford
1973-2024
The Coordinating Center
2018
Qingdao Municipal Center for Disease Control and Prevention
2018
University of Edinburgh
2011-2015
Western General Hospital
2011-2015
Institute of Genetics and Cancer
2015
Blood lipids are established risk factors for myocardial infarction (MI), but uncertainty persists about the relevance of lipids, lipoprotein particles, and circulating metabolites MI stroke subtypes. This study sought to investigate associations plasma metabolic markers with risks incident MI, ischemic (IS), intracerebral hemorrhage (ICH). In a nested case-control (912 1,146 IS, 1,138 ICH cases, 1,466 common control subjects) 30 79 years age in China Kadoorie Biobank, nuclear magnetic...
BackgroundStroke is a leading cause of death and disability worldwide. Despite considerable improvements in diagnosis treatment, little known about the short-term long-term prognosis after first stroke low-income middle-income countries, including China. We aimed to assess risk recurrent mortality for each major pathological types.MethodsThis population-based cohort study included adults aged 35–74 years without who were recruited China Kadoorie Biobank (CKB). A baseline survey was conducted...
Adherence to a combination of healthy lifestyle factors has been related considerable reduction cardiovascular risk in white populations; however, little is known whether such associations persist nonwhite populations like the Asian population.
Tobacco smoking is estimated to account for more than 1 million annual deaths in China, and the epidemic continues increase men. Large nationwide prospective studies linked different health records can help periodically assess disease burden attributed smoking. We aimed examine associations of with incidence mortality from an extensive range diseases China.We analysed data China Kadoorie Biobank, which recruited 512 726 adults aged 30-79 years, whom 210 201 were men 302 525 women....
Abstract Alcohol consumption accounts for ~3 million annual deaths worldwide, but uncertainty persists about its relationships with many diseases. We investigated the associations of alcohol 207 diseases in 12-year China Kadoorie Biobank >512,000 adults (41% men), including 168,050 genotyped ALDH2 - rs671 and ADH1B rs1229984 , >1.1 ICD-10 coded hospitalized events. At baseline, 33% men drank regularly. Among men, intake was positively associated 61 diseases, 33 not defined by World...
BackgroundThe age-specific association between blood pressure and vascular disease has been studied mostly in high-income countries, before the widespread use of brain imaging for diagnosis main stroke types (ischaemic intracerebral haemorrhage). We aimed to investigate this relationship among adults China.Methods512 891 (59% women) aged 30–79 years were recruited into a prospective study from ten areas China June 25, 2004, July 15, 2008. Participants attended assessment centres where they...
Evidence is sparse and inconclusive on the association between long-term fine (≤2.5 μm) particulate matter (PM
Integrated analyses of plasma proteomic and genetic markers in prospective studies can clarify the causal relevance proteins discover novel targets for ischemic heart disease (IHD) other diseases.
BackgroundIn developed countries, smoking is associated with increased risk of diabetes. Little known about the association in China, where cigarette consumption has (first urban, then rural areas) relatively recently. Moreover, uncertainty remains effect cessation on diabetes China and elsewhere. We aimed to assess associations incident among Chinese adults.MethodsThe prospective Kadoorie Biobank enrolled 512 891 adults (59% women) aged 30–79 years during 2004–08 from ten diverse areas...
China has high stroke rates despite the population being relatively lean. Uncertainty persists about relevance of adiposity to risk types. We aimed assess associations with incidence types and effect mediation by blood pressure in Chinese men women.The Kadoorie Biobank enrolled 512 891 adults aged 30-79 years from ten areas (five urban five rural) during 2004-08. During a median 9 (IQR 8-10) follow-up, 32 448 strokes (about 90% confirmed neuroimaging) were recorded among 489 301 participants...
Little evidence from large-scale cohort studies exists about the relationship of solid fuel use with hospitalization and mortality major respiratory diseases.To examine associations risks acute chronic diseases.A study 277,838 Chinese never-smokers no prior diseases at baseline. During 9 years follow-up, 19,823 first episodes or deaths diseases, including 10,553 lower disease (CLRD), 4,398 obstructive pulmonary (COPD), 7,324 infection (ALRI), were recorded. Cox regression yielded adjusted...
Increasing levels of high-density lipoprotein (HDL) cholesterol through pharmacologic inhibition cholesteryl ester transfer protein (CETP) is a potentially important strategy for prevention and treatment cardiovascular disease (CVD).To use genetic variants in the CETP gene to assess potential risks benefits lifelong lower activity on CVD other outcomes.This prospective biobank study included 151 217 individuals aged 30 79 years who were enrolled from 5 urban rural areas China June 25, 2004,...
Abstract Background Previous studies of primarily Western populations have reported contrasting associations dairy consumption with certain cancers, including a positive association prostate cancer and inverse colorectal premenopausal breast cancers. However, there are limited data from China where rates levels differ importantly those in populations. Methods The prospective Kadoorie Biobank study recruited ~0.5 million adults ten diverse (five urban, five rural) areas across during...
DNA methylation clocks emerged as a tool to determine biological aging and have been related mortality age-related diseases. Little is known about the association of age (DNAm age) with coronary heart disease (CHD), especially in Asian population.
In observational studies, type 2 diabetes is associated with two- to fourfold higher risk of cardiovascular diseases (CVD). Using data from the China Kadoorie Biobank (CKB), we examined associations genetically predicted CVD among ∼160,000 participants assess whether these relationships are causal. A genetic score (comprising 48 established variants) was presence carotid plaque (odds ratio 1.17 [95% CI 1.05, 1.29] per 1 unit log-odds diabetes; n = 6,819) and elevated ischemic stroke (IS)...
Abstract Background Little is known about the effects of maintaining healthy sleep patterns on frailty transitions. Methods Based 23,847 Chinese adults aged 30–79 in a prospective cohort study, we examined associations between and Healthy included duration at 7 or 8 h/d, without insomnia disorder, no snoring. Participants who persisted with pattern both surveys were defined as scored one point. We used 27 phenotypes to construct index three statuses: robust, prefrail, frail. Frailty...
Abstract Background The relevance of folic acid for stroke prevention in low-folate populations such as China is uncertain. Genetic studies the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism, which increases plasma homocysteine (tHcy) levels, could clarify causal elevated tHcy levels stroke, ischaemic heart disease (IHD) and other diseases without fortification. Methods In prospective Kadoorie Biobank, 156 253 participants were genotyped MTHFR 12 240 developed a during...
Bipolar disorder (BD) is a highly heritable psychiatric characterised by recurrent episodes of mania and depression. Many studies have reported altered gene expression in BD, some which may be attributable to the dysregulated miRNAs. Studies carried out date largely studied medicated patients, so it possible that observed changes miRNA might consequence clinical illness or its treatment. We sought establish whether play causative role development BD studying young, unmedicated relatives...
BackgroundHospitals in China are classified into tiers (1, 2 or 3), with the largest (tier 3) having more equipment and specialist staff. Differential health insurance cost-sharing by hospital tier (lower deductibles higher reimbursement rates lower tiers) was introduced to reduce overcrowding hospitals, promote use of limit escalating healthcare costs. However, little is known about effects differential schemes on choice tiers.MethodsIn a 9-year follow-up prospective study 0.5 M adults from...