A5047155850- Epigenetics and DNA Methylation
- Birth, Development, and Health
- RNA modifications and cancer
- Genetic Associations and Epidemiology
- Liver Disease Diagnosis and Treatment
- Obesity, Physical Activity, Diet
- Gestational Diabetes Research and Management
- Health, Environment, Cognitive Aging
- Combustion and flame dynamics
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Cardiovascular Health and Risk Factors
- Advanced Combustion Engine Technologies
- Nutritional Studies and Diet
- Cardiovascular Function and Risk Factors
- Diet and metabolism studies
- Fire dynamics and safety research
- Metabolomics and Mass Spectrometry Studies
- Long-Term Effects of COVID-19
- Cardiovascular Health and Disease Prevention
- Thermal Regulation in Medicine
- Iron and Steelmaking Processes
- Chemical Looping and Thermochemical Processes
- Tea Polyphenols and Effects
- Cancer Risks and Factors
Beijing Solar Energy Research Institute
2025
Peking University
2017-2024
Chinese Academy of Sciences
2024
Institute of Microbiology
2024
Harvard University
2020-2023
Harvard University Press
2023
Faculty of Public Health
2018
Shanxi Medical University
2015
Objective To examine the associations between egg consumption and cardiovascular disease (CVD), ischaemic heart (IHD), major coronary events (MCE), haemorrhagic stroke as well stroke. Methods During 2004–2008, over 0.5 million adults aged 30–79 years were recruited from 10 diverse survey sites in China. Participants asked about frequency of followed up via linkages to multiple registries active investigation. Among 461 213 participants free prior cancer, CVD diabetes, a total 83 977 incident...
Background Lung function is a heritable complex phenotype with obesity being one of its important risk factors. However, knowledge their shared genetic basis limited. Most genome-wide association studies (GWASs) for lung have been based on European populations, limiting the generalisability across populations. Large-scale GWASs in other populations are lacking. Methods We included 100 285 subjects from China Kadoorie Biobank (CKB). To identify novel loci function, single-trait GWAS analyses...
DNA methylation clocks emerged as a tool to determine biological aging and have been related mortality age-related diseases. Little is known about the association of age (DNAm age) with coronary heart disease (CHD), especially in Asian population.
Maternal pre-pregnancy obesity is an established risk factor for childhood obesity. Investigating epigenetic alterations induced by maternal during fetal development could gain mechanistic insight into the developmental origins of While disproportionately affects underrepresented racial and ethnic mothers children in USA, few studies investigated role prenatal programming intergenerational these high-risk populations.This study included 903 mother-child pairs from Boston Birth Cohort, a...
<h3>Objective</h3> To prospectively examine the association between tea consumption and risk of ischaemic heart disease (IHD). <h3>Methods</h3> Prospective study using China Kadoorie Biobank; participants from 10 areas across were enrolled during 2004–2008 followed up until 31 December 2013. After excluding with cancer, stroke at baseline, present included 199 293 men 288 082 women aged 30–79 years baseline. Information on IHD incidence was collected through registries new national health...
Objectives Chronic hepatitis B virus (HBV) infection is associated with a higher risk of liver diseases. Substantial uncertainty remains, however, about the associations HBV mortality from extrahepatic causes, especially subtypes cardiovascular We prospectively examined association chronic total and cause-specific mortality. Design Population-based prospective cohort study. Setting China Kadoorie Biobank in which participants 10 geographically diverse areas across were enrolled between 2004...
Health disparities correspond to differences in disease burden and mortality among socially defined population groups. Such may emerge according race/ethnicity, socioeconomic status a variety of other social contexts, are documented for wide range diseases. Here, we provide transdisciplinary perspective on the contribution epigenetics understanding health disparities, with special emphasis across racial/ethnic Scientists fields biological anthropology, bioinformatics molecular epidemiology...
The aim of this study is to evaluate the correlation left ventricular diastolic function and geometry in patients with obstructive sleep apnoea syndrome (OSAS) by echocardiography.The 181 diagnosed OSAS were divided into normal group (NG), concentric remodelling (CR), eccentric hypertrophy (EH) (CH). Pearson analysis multiple linear regression performed toward geometry.The E peak EH CH was significantly reduced, significant difference; E/A, Em, Am Em/Am reduced order CR, groups, while E/Em...
Existing evidence remains inconclusive as to the association between chronic hepatitis B virus (HBV) infection and risk of kidney disease (CKD). We prospectively examined HBV CKD risk, joint associations with established factors several lifestyle prevalent diseases on risk.Participants from China Kadoorie Biobank were enrolled during 2004-2008 followed up until 31 December 2015. After excluding participants previously diagnosed CKD, cancer, heart disease, stroke at baseline, present study...
To comprehensively examine the potential impacts of prenatal experience Chinese Great Famine on chronic disease risks in middle age.
Adherence to healthy lifestyles is associated with reduced risk of coronary heart disease (CHD), but uncertainty persists about the underlying lipid pathway. In a case–control study 4681 participants nested in prospective China Kadoorie Biobank, 61 lipidomic markers baseline plasma were measured by targeted nuclear magnetic resonance spectroscopy. Baseline included smoking, alcohol consumption, dietary habit, physical activity, and adiposity levels. Genetic instrument was used mimic...
In this paper, the influence factors on reduction degree of iron oxide were studied through a direct hydrogen thermogravimetric experiment. The results show that inlet flow rate and temperature both promote improvement degree, higher temperature, shorter time required for to reach maximum degree. entire process can be divided into three stages: Fe2O3 → Fe3O4 stage, FeO stage Fe stage. control mechanism each is based interfacial chemical reaction, second-order reaction respectively, linear...
Identifying environmentally responsive genetic loci where DNA methylation is associated with coronary heart disease (CHD) may reveal novel pathways or therapeutic targets for CHD. We conducted the first prospective epigenome-wide analysis of in relation to incident CHD Asian population.
Alterations in lipid metabolism and DNA methylation are 2 hallmarks of aging. Connecting metabolomic, epigenomic, aging outcomes help unravel the complex mechanisms underlying We aimed to assess whether clocks mediate association circulating metabolites with incident atherosclerotic cardiovascular disease (ASCVD) frailty.
DNA methylation (DNAm) has been implicated in acute coronary syndrome (ACS), but the causality remains unclear cross-sectional studies. Here, we conduct a prospective epigenome-wide association study of incident ACS two Chinese cohorts (discovery: 751 nested case-control pairs; replication: 476 pairs). We identified and validated 26 differentially methylated positions (DMPs, false discovery rate [FDR] <0.05), including three mapped to known cardiovascular disease genes (PRKCZ, PRDM16,...
Season of birth as a surrogate for potential environmental exposure during fetal development and early postnatal life has shown an inconsistent association with adult type 2 diabetes in white populations living high-latitude regions. The present study aimed to examine the between seasonality risk Chinese individuals across wide regions low latitude lower middle latitude. Participants from China Kadoorie Biobank were enrolled 2004–2008 followed up until 31 December 2013. After excluding...
Abstract Background: Several studies have reported that polygenic risk scores (PRSs) can enhance prediction of coronary artery disease (CAD) in European populations. However, research on this topic is far from sufficient non-European countries, including China. We aimed to evaluate the potential PRS for predicting CAD primary prevention Chinese population. Methods: Participants with genome-wide genotypic data China Kadoorie Biobank were divided into training ( n = 28,490) and testing sets...
The associations between blood lipids and DNA methylation have been investigated in epigenome-wide association studies mainly among European ancestry populations. Several explored the direction of using cross-sectional data, while evidence longitudinal data is still lacking.We tested peripheral leukocytes four lipid measures from Illumina 450 K or EPIC arrays 1084 participants Chinese National Twin Registry replicated result 988 China Kadoorie Biobank. A total 23 19 CpG sites were...
The open jet flame in hot co-flow (JHC) has been frequently utilized for fundamental investigations of Moderate or Intense Low-oxygen Dilution (MILD) combustion due to its controllable conditions and relatively easy measurement capabilities. However, practical MILD must take place within a combustor that is enclosed. Therefore, it necessary examine the similarity disparity characteristics between two configurations. This issue addressed currently. Specifically, we investigate flow mixing,...