A5100445615- Birth, Development, and Health
- Frailty in Older Adults
- Nutritional Studies and Diet
- Long-Term Effects of COVID-19
- Acute Ischemic Stroke Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Nutrition and Health in Aging
- Intensive Care Unit Cognitive Disorders
- Health Systems, Economic Evaluations, Quality of Life
- Intracerebral and Subarachnoid Hemorrhage Research
- Intracranial Aneurysms: Treatment and Complications
- Diet and metabolism studies
- Cerebrovascular and Carotid Artery Diseases
- COVID-19 Clinical Research Studies
- Chronic Disease Management Strategies
- Physical Activity and Health
- Neurological Disease Mechanisms and Treatments
- Dementia and Cognitive Impairment Research
- Amyotrophic Lateral Sclerosis Research
- Epigenetics and DNA Methylation
- Wound Healing and Treatments
- Ectopic Pregnancy Diagnosis and Management
- Cervical Cancer and HPV Research
- Corneal surgery and disorders
- Neuroinflammation and Neurodegeneration Mechanisms
University of Hong Kong
2007-2025
University of Hong Kong - Shenzhen Hospital
2025
Huangshi Central Hospital
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2024
Southern University of Science and Technology
2023-2024
Second Affiliated Hospital of Guangzhou Medical University
2023-2024
Guangzhou Medical University
2023-2024
West China Medical Center of Sichuan University
2022-2024
Inner Mongolia Medical University
2024
Beijing University of Chinese Medicine
2024
The full range of long-term health consequences COVID-19 in patients who are discharged from hospital is largely unclear. aim our study was to comprehensively compare between 6 months and 12 after symptom onset among survivors with COVID-19.We undertook an ambidirectional cohort had been Jin Yin-tan Hospital (Wuhan, China) Jan 7 May 29, 2020. At 6-month 12-month follow-up visit, were interviewed questionnaires on symptoms health-related quality life (HRQoL), received a physical examination,...
Biological age measurements (BAs) assess aging-related physiological change and predict health risks among individuals of the same chronological (CA). Multiple BAs have been proposed are well studied individually but not jointly. We included 845 3973 repeated from a Swedish population-based cohort examined longitudinal trajectories, correlations, mortality associations nine across 20 years follow-up. found growth functional accelerated around 70; average levels BA curves differed by sex span...
Axonal degeneration is a hallmark of many neuropathies, neurodegenerative diseases, and injuries. Here, using Drosophila injury model, we have identified highly conserved E3 ubiquitin ligase, Highwire (Hiw), as an important regulator axonal synaptic degeneration. Mutations in hiw strongly inhibit Wallerian multiple neuron types developmental stages. This new phenotype mediated by downstream target Hiw: the NAD+ biosynthetic enzyme nicotinamide mononucleotide adenyltransferase (Nmnat), which...
Abstract Objective This study aimed to investigate the current situation of oral frailty (OF) in elderly community China and analyse its influencing factors. Methods Using convenience sampling, 380 people from three communities our city were selected as participants study. The Oral Frailty Index-8, Scale, Health Assessment Tool, Mini-nutritional Scale Pittsburgh Sleep Quality Index used OF Results In this study, categorized into groups: frailty, pre-frailty, non-physical based on their...
Frailty index (FI) is a well-established predictor of all-cause mortality, but less known for cause-specific mortality and whether familial effects influence the associations. Middle-aged individuals are also understudied association between FI mortality. Furthermore, population impact frailty remains understudied.We estimated predictive value taking into account factors, tested associations time-dependent. We assessed proportion deaths that attributable to increased levels frailty. analyzed...
The prognostic role of immune cells in amyotrophic lateral sclerosis (ALS) remains undetermined. Therefore, we conducted a longitudinal cohort study including 288 ALS patients with up to 5-year follow-up during 2015–2020 recruited at the only tertiary referral center for Stockholm, Sweden, and measured levels differential leukocytes lymphocyte subpopulations. primary outcome was risk death after diagnosis secondary outcomes included functional status disease progression rate. Cox model used...
<h3>Objective</h3> To examine neuroanatomical changes associated with depressive symptoms in Alzheimer9s disease (AD) and the relationship between brain structure cerebrospinal fluid (CSF) AD biomarkers depressed non-depressed patients. <h3>Methods</h3> Two independent cohorts were used this study. The first cohort (KI) was collected from Memory Clinic at Karolinska University Hospital consisted of 41 second selected downloaded Alzheimer’s Disease Neuroimaging Initiative database (ADNI) 148...
Annexins are an evolutionarily conserved multigene family of calcium-dependent phospholipid binding proteins that play important roles in stress resistance and plant development. They have been relatively well characterized model plants Arabidopsis (Arabidopsis thaliana) rice (Oryza sativa), but nothing has reported hexaploid bread wheat (Triticum aestivum) barely (Hordeum vulgare), which the two most economically plants. Based on available genomic transcriptomic data, 25 11 putative annexin...
<h3>Objective</h3> To prospectively examine the association between tea consumption and risk of ischaemic heart disease (IHD). <h3>Methods</h3> Prospective study using China Kadoorie Biobank; participants from 10 areas across were enrolled during 2004–2008 followed up until 31 December 2013. After excluding with cancer, stroke at baseline, present included 199 293 men 288 082 women aged 30–79 years baseline. Information on IHD incidence was collected through registries new national health...
Abstract Background Biochemical changes in the cerebrospinal fluid ( CSF ) could reflect pathophysiological processes Alzheimer's disease AD ). However, it is still not clear how these correlate with grey matter GM volume and microstructural brain. Objective To assess relationship between biomarkers structural brain . Design setting Cross‐sectional study a memory clinic‐based sample. Subjects A total of 78 subjects were included study: 22 subjective cognitive impairment SCI ), 35 mild MCI 21...
frailty shows an upward trajectory with age, and higher levels increase the risk of mortality. However, it is less known whether shape trajectories differs by age at death or rate change in associated mortality.to assess population to analyse current level index (FI) i.e. most recent measurement person-specific more predictive mortality.3,689 individuals from three population-based cohorts up 15 repeated measurements Rockwood were analysed. The FI assessed stratifying sample into four...
Abstract Aging is a major risk factor for many chronic diseases. This study aimed to examine the effects of antihypertensive, lipid-lowering, and antidiabetic drugs on biological aging. We included 672 participants 2746 repeated measurements from Swedish Adoption/Twin Study Aging. Self-reported medicine uses were categorized into antidiabetic, lipid-lowering drugs. A total 12 biomarkers aging (BA biomarkers) as outcomes. Conditional generalized estimating equations applied conditioning...
Central nervous system (CNS) infections can cause significant morbidity and mortality, especially in children. Rapid accurate pathogenic detection suspected CNS is essential for disease control at the early stage of infection. To evaluate performance metagenomic next-generation sequencing (mNGS) cell-free DNA (cfDNA) cerebrospinal fluid (CSF) pediatric patients, we retrospectively analyzed efficiency cfDNA mNGS children with (n = 257) or noninfectious neurological disorders 81). The CSF...
Nitric oxide, when released into the bloodstream, is quickly scavenged by Hb in erythrocytes or oxidized to nitrite. Nitrite can also enter and oxidize Hb. The goals of this work were determine mechanism erythrocyte nitrite uptake whether causes oxidant stress these cells. Erythrocytes took up 0.8 mM with a half-time 11 min. was sensitive temperature pH ionic composition medium but not inhibited specific anion-exchange inhibitor DIDS. About 25% occurred on sodium-dependent phosphate...
Familial Alzheimer's disease (FAD) resulting from gene mutations in PSEN1, PSEN2 and APP is associated with changes the brain.The aim of this study was to investigate grey matter (GM), white (WM) cerebrospinal fluid (CSF) FAD.Ten mutation carriers (MCs) three different PSEN1 20 noncarriers (NCs) were included study. Three MCs symptomatic seven presymptomatic (pre-MCs).Whole-brain GM volume as well fractional anisotropy (FA) mean diffusivity (MD) using voxel-based morphometry tract-based...