A5020436057- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Neurosurgical Procedures and Complications
- Vascular Malformations Diagnosis and Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- RNA modifications and cancer
- Moyamoya disease diagnosis and treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Ubiquitin and proteasome pathways
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- RNA Research and Splicing
- Bioinformatics and Genomic Networks
- Parkinson's Disease Mechanisms and Treatments
- Ferroptosis and cancer prognosis
- Immune Cell Function and Interaction
- Cardiac, Anesthesia and Surgical Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- MicroRNA in disease regulation
- Biochemical and Molecular Research
- Healthcare Operations and Scheduling Optimization
- Acute Ischemic Stroke Management
- Monoclonal and Polyclonal Antibodies Research
- Surgical Simulation and Training
- RNA and protein synthesis mechanisms
Zhongnan Hospital of Wuhan University
2019-2025
Wuhan University
2019-2025
First Affiliated Hospital of Zhengzhou University
2025
Heze Municipal Hospital
2021
General Hospital of Central Theater Command
2021
Lanzhou Army General Hospital
2014-2016
Peking Union Medical College Hospital
2010-2012
Chinese Academy of Medical Sciences & Peking Union Medical College
2010-2012
Salvianolic acid B (SalB), a bioactive compound isolated from the plant-derived medicinal herb Danshen, has been shown to exert various anti-oxidative and anti-inflammatory activities in several neurological disorders. In this study, we sought investigate potential protective effects associated molecular mechanisms of SalB Parkinson's disease (PD) models. To determine neuroprotective vitro, MPP+- or lipopolysaccharide (LPS)-induced neuronal injury was achieved using primary cultures with...
Background Immune checkpoint blockade (ICB)-based immunotherapy has significantly improved survival in advanced melanoma. However, many patients exhibit resistance to these therapies. This study examines the impact of BTLA promoter methylation on its expression, immune cell infiltration, and clinical outcomes, evaluating potential as a prognostic predictive biomarker for response. Methods We analyzed gene expression data from public datasets (The Cancer Genome Atlas (TCGA), Gene Expression...
Sex differences in the outcomes of patients with aneurysmal subarachnoid hemorrhage (aSAH) remain controversial. The aim this study was to evaluate sex aSAH.This retrospectively analyzed clinical data consecutive aSAH, admitted Department Neurosurgery, Wuhan University Zhongnan Hospital, from May 1, 2020 December 31, 2020. modified Rankin Scale (mRS) score used prognosis at discharge. Outcome indicators included cerebral ischemia, hydrocephalus, and mRS ≥ 2 discharge.The majority (65%) 287...
Osteosarcoma, which arises from bone tissue, is considered to be one of the most common types cancer in children and teenagers. As etiology osteosarcoma has not been fully elucidated, overall prognosis for patients generally poor. In recent years, development bioinformatical technology allowed researchers identify numerous molecular biological characteristics associated with using online databases. present study, Gene Expression Omnibus (GEO) database was used three microarray datasets were...
BACKGROUND: Thromboembolic complications are one of the major periprocedural following neuroendovascular procedures. Dual antiplatelet therapy (DAPT) with aspirin and clopidogrel remain principal agents for prevention thromboembolic complications. However, resistance is associated higher risk This study investigated safety efficacy DAPT ticagrelor in patients undergoing intracranial stenting procedures.METHODS: retrospective was based on aneurysms who procedures at our institution between...
Although endovascular recanalization is considered a more effective treatment for chronic internal carotid artery occlusion (CICAO), the success rate of complex CICAO remains inadequate. We present hybrid surgery (carotid endarterectomy combined with stenting) and explore influential factors effects recanalization.We retrospectively analyzed clinical, imaging, follow-up data 22 patients treated by at Zhongnan Hospital Wuhan University from December 2016 to 2020. also summarize technical...
Background There have been few reports on the use of tirofiban in ruptured intracranial aneurysms and results were conflicting. However, safety efficacy optimal dosage reasonable treatment course not determined. Objective To determine a new protocol for its prophylactic application during endovascular with no oral antiplatelet medications. Methods This retrospective study was based 105 patients who underwent stent-assisted coiling at our institution between August 2017 July 2020. Intravenous...
Background Basal ganglia and thalamic arteriovenous malformations (AVMs) represent a special subset of malformations. Due to the involvement vital brain structures specifically fine delicate angioarchitecture these lesions, it presents unique therapeutic challenges technical difficulties that require thorough treatment planning, individualized strategies, advanced techniques for good clinical outcome. Method In this study, we presented series ruptured basal AVMs embolized via transarterial,...
Configuration changes of the parent artery (PA) after flow-diverter (FD) stent reconstruction, caused by bending force device, may have an additional role in aneurysm occlusion as a result secondary alteration intra-aneurysmal hemodynamics related to geometry vessel. To determine degree PA deformation and rates deployment 2 different types FD.
Objective Intracranial intracranial dural arteriovenous fistulas (DAVFs) are mainly treated with an endovascular approach and various embolic agents. The aim of this study was to investigate the efficacy safety Onyx embolization in treatment DAVFs characterize factors as sociated complete obliteration. Methods This retrospective based on 62 patients who underwent alone or combination coils at our institution. Clinical imaging data were collected analyzed. Results A total 64 embolization....
Background: Cytotoxic CD8+ T-cell exhaustion is the major barrier for immunotherapy in tumors. Recent studies have reported that basic leucine zipper activating transcription factor–like factor (BATF) responsible countering cytotoxic exhaustion. Nevertheless, expression and roles of BATF tumors been poorly explored. Methods: In present study, we conducted a multi-omics analysis, including gene expression, methylation status, DNA alterations, pharmacogenomics, survival status based on data...
To construct a miR-23a-27a cluster expression plasmid and to explore the target genes function of cluster.The pre-miR-23a-27a-pcDNA3.1, pre-miR-23a pre-miR-27a plasmids were cloned by molecular biology method, their efficiency was tested dual luciferase reporter gene assay real-time PCR. Several possible miR-23a miR-27a chosen using softwares further assay. Finally, analyzed in MCF-7 cell Western blot PCR.miR-23a transcribed from HEK293T cells, both influenced MRE Sprouty2 pRL-TK vector,...
Abstract Objectives To evaluate the safety and effectiveness of one-stop hybrid surgery microsurgical resection combined with preoperative embolization or intraoperative angiography for brain arteriovenous malformations (bAVMs) compare efficacy nonhybrid (endovascular alone) in treatment bAVMs. Methods A single-center retrospective study was performed to recruit 70 patients bAVMs at our hospital between July 2017 April 2020. Patients were divided into 2 groups depending on mode surgery:...
To construct certain chimeric E3s expression plasmids targetting oncoprotein Ras by harnessing the theory of protein knockdown.We chose binding domain Raf-1, PI3K, RalGDS, and function F-Box as well U-Box to plasmids. Then used double enzyme, PCR, sequence test validity integrity cloned nucleotide fragments. The efficiency in eukaryotic cells was detected Western blot analysis.Five 6 this study expressed corresponding fusion proteins HEK293T cells, (RBD+CRD)(Raf-1)- U-Box-pcDNA3.1 can...
OBJECTIVE To study the effect of transfecting survivin antisense mRNA on growth and chemotherapy sensitivity lymphoma cells. METHODS Eukaryotic expression plasmid pcDNA3. 1-antisense (As) was constructed transfected into Jurkat T lymphoblastic cell lines with high by use lipofectmine gene transfer technique. Expression protein were detected reverse transcription-polymerase chain reaction (RT-PCR), immunohistochemical Western blot. The monitored population doubling time (PDT) Apoptotic...
Abstract Objectives To evaluate the safety and effectiveness of one-stop hybrid surgery microsurgical resection combined with preoperative embolization or intraoperative angiography for brain arteriovenous malformations (bAVMs) compare efficacy nonhybrid (endovascular alone) in treatment bAVMs. Methods A single-center retrospective study was performed to recruit 70 patients bAVMs at our hospital between July 2017 April 2020. Patients were divided into 2 groups depending on mode surgery:...