A5101530141- Cancer-related gene regulation
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Cancer Cells and Metastasis
- Esophageal Cancer Research and Treatment
- Lung Cancer Treatments and Mutations
- Cancer-related Molecular Pathways
- RNA modifications and cancer
- Radiomics and Machine Learning in Medical Imaging
- Sarcoma Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Colorectal Cancer Surgical Treatments
- Synthesis and Characterization of Heterocyclic Compounds
- Cancer Research and Treatments
- Cancer Genomics and Diagnostics
- Lung Cancer Research Studies
- Bone Tumor Diagnosis and Treatments
- Tumors and Oncological Cases
- Angiogenesis and VEGF in Cancer
- Vascular Anomalies and Treatments
- Bioactive Compounds and Antitumor Agents
- Nuclear Receptors and Signaling
- Inflammatory Biomarkers in Disease Prognosis
- Immunotherapy and Immune Responses
- Ubiquitin and proteasome pathways
First Affiliated Hospital of Zhengzhou University
2010-2025
Zhengzhou University
2021
N6 methyladenosine (m6A) RNA methylation regulators play an important role in the development of tumors. However, their function esophageal cancer (EC) has not been fully elucidated. Here, we analyzed gene expression data 24 major m6A from 775 patients with EC TCGA dataset. The present study showed aberrations genome were correlated to prognosis human ECs. Meanwhile, 17 increased samples, including YTHDC1, IGF2BP2, FTO, METTL14, YTHDF3, RBM15, WTAP, HNRNPA2B1, HNRNPC, ALKBH5, YTHDF2,...
To analyze the value of amide proton transfer (APT) weighted and intravoxel incoherent motion (IVIM) imaging in evaluation prognostic factors for rectal adenocarcinoma, compared with diffusion (DWI).Preoperative pelvic MRI data 110 patients surgical pathologically confirmed diagnosis adenocarcinoma were retrospectively evaluated. All underwent high-resolution T2-weighted (T2WI), APT, IVIM, DWI. Parameters including APT signal intensity (APT SI), pure coefficient (D), pseudo-diffusion (D*),...
Background Immune checkpoint blockade (ICB)-based immunotherapy has significantly improved survival in advanced melanoma. However, many patients exhibit resistance to these therapies. This study examines the impact of BTLA promoter methylation on its expression, immune cell infiltration, and clinical outcomes, evaluating potential as a prognostic predictive biomarker for response. Methods We analyzed gene expression data from public datasets (The Cancer Genome Atlas (TCGA), Gene Expression...
Abstract Esophageal adenocarcinoma (EAC), a subtype of esophageal carcinoma, is severe health problem associated with high death rate and poor prognosis. Immunotherapy has proven to be effective in many solid tumors, including EAC, but immune escape blocks its effectiveness. Thus, we explored the mechanisms functional role c‐Myb EAC cells. Clinical tissues were collected for determining expression c‐Myb, speckled POZ protein (SPOP), miR‐145‐5p. Functional assays then performed detect...
Esophageal cancer is the eighth most common malignancy and sixth leading cause of deaths in world. Recent studies have shown potential role aryl hydrocarbon receptor (AhR) tumor development; however, little known about its esophageal squamous cell carcinoma. In present study, we evaluated AhR expression tissues as well lines investigated effects activation by agonist BNF on carcinoma invasion using Eca109 TE-13 cells a model.Western blotting was performed to detect CYP1A1 protein expression....
Background: Esophageal cancer (EC) is one of the deadliest cancers in world. However, mechanism that drives evolution EC still unclear. On this basis, we identified key genes and molecular pathways may be related to progression esophageal adenocarcinoma squamous cell carcinoma find potential markers or therapeutic targets. Methods: GSE26886 were obtained from Gene Expression Omnibus (GEO) database. The differentially expressed (DEGs) among normal samples, EA, determined using R software....
Various blood inflammatory biomarkers were associated with treatment response and prognosis of non-small cell lung cancer (NSCLC) in previous studies. In this study, we retrospectively evaluated the prognostic role pretreatment epidermal growth factor receptor (EGFR) mutation status stage IIIA/N2 NSCLC patients trimodality therapy.Completely resected adjuvant chemotherapy postoperative radiotherapy (PORT) assessed study. Cutoff values factors calculated by R package SurvivalROC software....
Background: The treatment choice for completely resected stage IIIA/N2 non-small cell lung cancer (NSCLC) patients is still controversial now. Our study aims to identify potential prognostic factors in NSCLC with complete surgical resection and postoperative chemotherapy. Methods: In this study, we screened the diagnosed Affiliated Cancer Hospital of Zhengzhou University from 2015 2019. Completely chemotherapy (PCT) were enrolled. univariate multivariate COX proportional hazards regression...
Objective: To investigate the clinical symptoms, imaging features, pathologic manifestations and diagnosis of tracheobronchopathia osteochondroplastica (TO). Methods: The data, features outcome 18 TO patients diagnosed at First Affiliated Hospital Zhengzhou University from August 2011 to 2018 were collected analyzed. Results: included 10 males 8 females; patients' age range was 31 64 years (mean 52 years). Six (6/18) smokers. main presenting symptoms cough in 15 cases, expectoration eight...
目的：探讨VEGF．C、VEGFR．3、CDl05及cD68蛋白在食管鳞状细胞癌（EScc）组织中的表达及其与血管和淋巴管转移的关系．方法：应用免疫组化SP法检测50例ESCC、19例癌旁不典型增生组织及50例正常食管黏膜组织中VEGF．C、VEGFR．3、CD105和CD68蛋白的表达．分析这些蛋白表达与ECC临床生物学行为的关系．结果：ESCC、癌旁不典型增生组织及正常黏膜组织中VEGF．C、VEGFR一3、CD105和CD68蛋白的阳性表达率依次降低（VEGF—C：82．0％，47．4％，26．0％：VEGFR一3：72．0％，36．8％，18，0％：CDl05：30．53±7．42，0，0：CD68：50．89±10．36．14．10±3．59．11．30±3．72），组间比较差异均有统计学意义（欧0．05）；VEGF．C、CDl05和CD68蛋白均与肿瘤的TNM分期、浸润深度、淋巴结转移密切相关（均尸〈0．05），vEGFR．3蛋白表达与肿瘤的淋巴结转移密切相关f均尸〈0．051．ESCC组织中vEGF—C蛋白表达与vEGFR一3呈正相关关系俨〈0．01），vEGF．C...