A5062767178- Intracranial Aneurysms: Treatment and Complications
- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Stroke Rehabilitation and Recovery
- Moyamoya disease diagnosis and treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Atomic and Subatomic Physics Research
- Advanced MRI Techniques and Applications
- Neurosurgical Procedures and Complications
- Cardiac Valve Diseases and Treatments
- Vascular Malformations Diagnosis and Treatment
- Cardiac Structural Anomalies and Repair
- Diabetic Foot Ulcer Assessment and Management
- Bone Tumor Diagnosis and Treatments
- Anatomy and Medical Technology
- Mechanical Circulatory Support Devices
- Connective tissue disorders research
- Central Venous Catheters and Hemodialysis
- Sarcoma Diagnosis and Treatment
- Vascular Procedures and Complications
- Glioma Diagnosis and Treatment
- Adrenal and Paraganglionic Tumors
- Cardiac tumors and thrombi
University Hospital Schleswig-Holstein
2014-2025
University of Lübeck
2014-2025
University Hospital of Zurich
2021-2025
University of Zurich
2023-2024
Siemens (Switzerland)
2024
Clinical Research Center Kiel
2021
Universitäts Hautklinik Kiel
2020
Kiel University
2019
<h3>BACKGROUND AND PURPOSE:</h3> Recent studies have suggested that wall enhancement of unruptured intracranial aneurysms in high-resolution MR imaging might serve as an biomarker for higher risk rupture. Histologic revealed a possible association among inflammatory processes, degeneration, and destabilization the aneurysm preceding Understanding histologic condition underlying could be important step toward assessing value this method stratification. We present our observations vessel...
Purpose A first-pass, direct aspiration technique and stent retrieval with a balloon guide catheter represent advanced thrombectomy techniques that are increasingly being used in the clinical routine. The purpose of this experimental study was to evaluate whether techniques’ effectiveness depended on clot composition visualize interaction between devices clot. Materials Methods Erythrocyte-rich (red) fibrin-rich (white) clots were placed into M1-segment middle cerebral artery transparent...
Background: The predictive value of thrombus perviousness in acute ischemic stroke (AIS), as measured by computed tomography (CT), has been intensively studied with conflicting results. In this study, we investigate the potential novel concept dynamic using three-dimensional (3D) volumetric evaluation occlusive thrombi. Methods: full volume 65 patients a hyperdense artery sign on non-contrast CT (NCCT), who underwent mechanical thrombectomy (MT), was segmented. Perviousness maps were...
The impact of therapeutic embolization as a stand-alone treatment head and neck paragangliomas considered surgically high-risk remains insufficiently understood. aim this study was to investigate the procedural risks long-term volumetric development in with high surgical risk following endovascular treatment.
Dynamic perviousness is a novel imaging biomarker, with clot density measurements at multiple timepoints to allow longer contrast thrombus interaction. We investigated the correlations between dynamic and composition in setting of acute ischemic stroke. Thirty-nine patients large vessel occlusion (LVO) undergoing mechanical thrombectomy (MT) were analyzed. Patients received three-phase CT pre-thrombectomy histopathological analysis retrieved clots. Clot densities for every phase change...
Abstract Background Endovascular therapy (EVT) for large intracranial vessel occlusion or symptomatic hypoperfusion due to cervical artery dissection (CeAD) became the standard in recent years. Stenting is frequently required secure with subsequent need GP IIb/IIIa inhibitors. However, a potential concern of antithrombotic acute stroke increased risk intracerebral hemorrhage. The aim study was assess impact administration inhibitor imaging during endovascular treatment ischemic caused by...
Mechanical thrombectomy is less effective in patients aged 80 years or older. Our goal was to better understand the impact of age general on recanalization rates and clinical outcome.We performed a retrospective analysis our prospective database adult with acute ischemic stroke due large vessel occlusions, who had undergone mechanical between 2019 mid-2021. The cohort categorized into five groups: 18 - 49, 50 59, 60 69, 70 79 ≥ years. primary outcome measure at three months after...
A significant number of patients who present with mild symptoms following large-vessel occlusion acute ischemic stroke (LVO-AIS) are currently considered ineligible for EVT. However, they frequently experience neurological deterioration during hospitalization. This study aimed to investigate the association between and hemodynamic impairment by assessing steal phenomenon derived from blood oxygenation-level dependent cerebrovascular reactivity (BOLD-CVR) in this specific patient cohort.
Background: The predictive value of thrombus standard perviousness (SP) in acute ischemic stroke (AIS) for the technical success rates mechanical thrombectomy (MT) or functional outcomes is not yet conclusive. We investigated relationship between dynamic (DP) and revascularization results using time-dependent enhancement curve types determined with computed tomography (CT). Methods: A retrospective analysis 137 AIS patients was performed. DP calculated as attenuation increase (TAI) three...
Various stent retrievers differing in design and mechanical properties are currently available for the treatment of ischemic stroke. We conducted this vitro study to compare efficacy, embolism rate, safety commercially prototypes. Whole blood thrombi were produced a Chandler loop. The inserted into curved M1 segment silicone model anterior cerebral circulation. Thrombectomy maneuvers performed with six 2 prototypes different strut thickness. Wall-stent apposition, first pass recanalization...
Purpose The contour neurovascular system (CNS) is an intrasaccular flow-disrupting device designed for the treatment of intracranial wide-necked bifurcation aneurysms. Metal artifacts limit magnetic resonance imaging (MRI) accessibility after implantation. purpose this in vitro study was to evaluate non-invasive alternatives digital subtraction angiography (DSA). Material and methods Three aneurysms patients originally treated with CNS were three-dimensional (3D)-printed (one at basilar tip...
Background: Acute ischemic stroke (AIS) is one of the leading causes death in industrialized world and a heavy personal economic burden. Thrombus perviousness, measured with pre-interventional computed tomography (CT), relatively new imaging biomarker potential to estimate clinical outcome AIS optimize therapy. However, reported findings on relationship between thrombus perviousness parameters are conflicting. In this study, we investigated characteristics time-resolved contrast agent uptake...
Background The patency of intracranial stents may not be reliably assessed with either CT angiography or MR due to imaging artifacts. We investigated the potential ultra-high resolution using a photon counting detector (PCD) address this limitation by optimizing scanning and reconstruction parameters. Methods A phantom different flow diverters was used optimize PCD-CT parameters, followed 14 patients PCD-CT. Images were reconstructed three kernels based on results (Hv56, Hv64, Hv72; Hv=head...
Spontaneous dissection of the internal carotid artery (CAD) is an increasingly recognized cause for stroke especially in young and middle-aged patients. We hypothesized that non-enhanced cranial computed tomography (NECCT) can visualize subpetrous wall hematoma thus enable identification patients with CAD.We retrospectively reviewed confirmed CAD (n = 21) a control group ischemic symptoms but without 42) who received NECCT at admission. Two independent neuroradiologists rated presence shape...
Flow diversion treatment of ruptured cerebral aneurysms remains challenging due to the need for double-antiplatelet therapy. We report our experience with flow-diverter stent (FDS) reconstruction single-antiplatelet therapy blood blister and dissecting aneurysms.In this case series we performed a retrospective analysis all patients who were treated phosphoryl-bonded FDS between 2019 2022 in single center. Periprocedurally, received weight-adapted eptifibatide IV heparin IV. After 6-24 hours,...
A direct aspiration first pass technique (ADAPT) is an effective thrombectomy option in patients with acute ischemic stroke. Balloon guide catheters (BGC) seem to improve the efficacy of stent retrievers and ADAPT. The last generation 6F require 9F BGCs, which are rigid devices that challenging position a tortuous anatomy. In this experimental study ADAPT alone 5F combined 8F BGC was evaluated. Either fibrin rich (white) clot or RBC (red) placed M1 segment transparent silicon phantom....
Off-pump transcatheter valved stent implantation could be a treatment option for patients suffering from symptomatic tricuspid regurgitation (TR) who are classified as inoperable. In this study, we present our recent short-term results of transventricular and compare different types atrial anchorage. Fifteen pigs received self-expandable off-pump via access. Successfully implanted were observed over period 6 h (n = 9), 48 1) 4 weeks 1). Haemodynamic full transoesophageal echocardiographic...