A5048554505- Nanoparticle-Based Drug Delivery
- Ultrasound and Hyperthermia Applications
- Photoacoustic and Ultrasonic Imaging
- Advanced Photonic Communication Systems
- Advanced Polymer Synthesis and Characterization
- Optical Network Technologies
- Graphene and Nanomaterials Applications
- biodegradable polymer synthesis and properties
- Advanced Optical Network Technologies
- Ultrasound Imaging and Elastography
- Ultrasound and Cavitation Phenomena
- Advanced Drug Delivery Systems
- Nanoplatforms for cancer theranostics
- Surface and Thin Film Phenomena
- Intelligent Tutoring Systems and Adaptive Learning
- Traditional Chinese Medicine Analysis
- Acute Lymphoblastic Leukemia research
- Natural product bioactivities and synthesis
- Dendrimers and Hyperbranched Polymers
- Acute Myeloid Leukemia Research
- Glaucoma and retinal disorders
- Laser Material Processing Techniques
- Retinal Diseases and Treatments
- Electron and X-Ray Spectroscopy Techniques
- Eicosanoids and Hypertension Pharmacology
Washington University in St. Louis
2020-2025
Jiangxi Science and Technology Normal University
2014-2024
Shanghai University
2013-2024
Bengbu Medical College
2024
Suzhou Municipal Hospital
2022-2024
Nanjing Medical University
2019-2024
Peking University
2022-2023
Peking University First Hospital
2022-2023
Michigan State University
2022
Zhongnan Hospital of Wuhan University
2021
Abstract Torpor is an energy-conserving state in which animals dramatically decrease their metabolic rate and body temperature to survive harsh environmental conditions. Here, we report the noninvasive, precise safe induction of a torpor-like hypothermic hypometabolic rodents by remote transcranial ultrasound stimulation at hypothalamus preoptic area (POA). We achieve long-lasting (>24 h) mice via closed-loop feedback control with automated detection temperature. Ultrasound-induced...
Advancing our understanding of brain function and developing treatments for neurological diseases hinge on the ability to modulate neuronal groups in specific areas without invasive techniques. Here, we introduce Airy-beam holographic sonogenetics (AhSonogenetics) as an implant-free, cell type–specific, spatially precise, flexible neuromodulation approach freely moving mice. AhSonogenetics utilizes wearable ultrasound devices manufactured using 3D-printed metasurfaces. These are designed...
Abstract Background. Noninvasive and cell-type-specific neuromodulation tools are critically needed for probing intact brain function. Sonogenetics noninvasive activation of neurons engineered to express thermosensitive transient receptor potential vanilloid 1 (TRPV1) by transcranial focused ultrasound (FUS) was recently developed address this need. However, using TRPV1-mediated sonogenetics evoke behavior targeting the cortex is challenged its proximity skull due high absorption increased...
Glioma is among the deadliest types of brain cancer, for which there currently no effective treatment. Chemotherapy mainstay in treatment glioma. However, drug tolerance, non-targeting, and poor blood-brain barrier penetrance severely inhibits efficacy chemotherapeutics. An improved method thus urgently needed. Herein, a multifunctional biomimetic nanoplatform was developed by encapsulating graphene quantum dots (GQDs) doxorubicin (DOX) inside homotypic cancer cell membrane (CCM) targeted...
Boron nitride nanomaterials are being increasingly recognized as vehicles for cancer drug delivery that increase loading and control release because of their excellent physicochemical properties biocompatibility. However, these nanoparticles often cleared rapidly by the immune system have poor tumor targeting effects. As a result, biomimetic nanotechnology has emerged to address challenges in recent times. Cell-derived carriers characteristics good biocompatibility, long circulation time,...
Microgels, with large surface area per volume, show great advantages in adipose tissue engineering due to their injectability and similarity natural extracellular matrix. However, date, no studies have tried applying microgels regeneration. Herein, based on double-bonded poly(l-glutamic acid)-g-2-hydroxyethyl methacrylate (PLGA-g-HEMA) maleic anhydride-modified chitosan (MCS), an open porous microgel high hydrophilicity is successfully prepared (microgels diameters of 200–300 μm, pore...
A series of novel ligustrazine-oleanolic acid (TOA) derivatives were designed, and synthesized by conjugating amino acids to the 3-hydroxy group TOA ester bonds. Their cytotoxicity was evaluated on four cancer cell lines (HepG2, HT-29, Hela BGC-823) standard MTT assays. The ClogP values calculated means computer simulation, logP both 3β-glycine olean-12-en-28-oic acid-3,5,6-trimethylpyrazin-2-methyl (6a) determined using a shake flask-ultraviolet spectrophotometry method. It found that 6a...
Diffuse intrinsic pontine glioma (DIPG) is the most common and deadliest brainstem tumor in children. Focused ultrasound combined with microbubble-mediated BBB opening (FUS-BBBO) a promising technique for overcoming frequently intact blood-brain barrier (BBB) DIPG to enhance therapeutic drug delivery brainstem. Since highly diffusive, large-volume FUS-BBBO needed cover entire region. The objective of this study was determine optimal treatment strategy achieve efficient homogeneous BBBO at an...
Focused ultrasound (FUS)-enabled liquid biopsy (sonobiopsy) is an emerging technique for the noninvasive and spatiotemporally controlled diagnosis of brain cancer by inducing blood-brain barrier (BBB) disruption to release tumor-specific biomarkers into blood circulation. The feasibility, safety, efficacy sonobiopsy were demonstrated in both small large animal models using magnetic resonance-guided FUS devices. However, high cost complex operation devices limit future broad application...
Aim: To explore the better efficacy of targeted folic acid (FA)-Pluronic 85-poly(lactide-co-glycolide) (FA–P85–PLGA) polymersome in oral insulin delivery. Materials & methods: The cytotoxicity polymers, vitro qualitative and quantitative cellular uptake internalization mechanism insulin-loaded FA–P85–PLGA PLGA–P85–PLGA polymersomes were studied with human colon adenocarcinoma cells (Caco-2 cells). Their pharmacodynamics pharmacokinetics properties also diabetic rats. Results conclusion:...
The glymphatic system regulates cerebrospinal fluid (CSF) transport and brain waste clearance. Focused ultrasound combined with microbubbles (FUSMB) has shown feasibility for manipulating transport, yet its mechanisms remain poorly understood. In this work, we used in vivo two-photon microscopy to reveal how FUSMB manipulates the CSF tracer mouse brain. A FUS transducer was confocally aligned objective of a microscope. Fluorescently labeled albumin infused into via cisterna magna. sonication...
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition characterized by diverse clinical presentations, often associated with dysregulated oxidative stress mechanisms leading to heightened production of reactive oxygen species (ROS) in the brain. Due its multifactorial etiology, effective therapeutic approaches for ASD remain challenging ascertain. This work engineers Prussian blue nanoparticles (PB NPs) designed mimic enzymatic functions key antioxidants such as superoxide...
Focused ultrasound (FUS) combined with microbubble-mediated blood-brain barrier (BBB) opening (FUS-BBBO) is not only a promising technique for clinical applications but also powerful tool preclinical research. However, existing FUS devices research are expensive, bulky, and lack the precision needed small animal research, which limits broad adoption of this by community. Our objective was to design fabricate an affordable, easy-to-use, high-precision device research.We designed fabricated...
Objective and Impact Statement . To develop an approach for individualized closed-loop feedback control of microbubble cavitation to achieve safe effective focused ultrasound in combination with microbubble-induced blood-brain barrier opening (FUS-BBBO). Introduction FUS-BBBO is a promising strategy noninvasive localized brain drug delivery growing number clinical studies currently ongoing. Real-time monitoring are critical achieving FUS-BBBO. However, algorithms used the past were either...
// Zongwei Lin 1,* , Shao Qian 3,* Yan Gong 2,* Jianwei Ren 6 Lixia Zhao 4 Dongxiao Wang 5 Xiaowei 1 Yun Zhang Zhe 2 and Qunye The Key Laboratory of Cardiovascular Remodeling Function Research, Chinese Ministry Education Health, State Shandong Province Joint Translational Medicine, Qilu Hospital University, Jinan, China Division Endocrinology Metabolism, Provincial Affiliated to 3 Department Women Health Care, Jinan Maternity Child Care Hospital, Pharmacy Medical College, Pharmacy, PLA...
The human ether-a-go-go-related gene (hERG) encodes the α subunit of IKr, which plays an essential role in repolarization action potentials. hERG channels are targeted by various pro-arrhythmic drugs. Berberine (BBR) was previously found to acutely inhibit currents and prolong potential duration. present study aimed determine long-term effects BBR on expression 135kDa/155kDa mechanism.hERG assessed western blot. Mature (155 kDa) reduced, whereas ER-located (135 increased BBR. This indicated...
A new anticancer ligustrazine derivative, 3β-hydroxyolea-12-en-28-oic acid- 3,5,6-trimethylpyrazin-2-methylester (T-OA, C38H58O3N2), was previously reported. It synthesized via conjugating hepatoprotective and ingredients of traditional Chinese medicine. We found that T-OA exerted its activity by preventing the expression nuclear transcription factor NF-κB/p65 COX-2 in S180 mice. However, selective cytotoxicity on various kinds cell lines has not been studied sufficiently. In present study,...
Abstract Targeted drug delivery systems have attracted increasing attention due to their ability for delivering anticancer drugs selectively tumor cells. Folic acid (FA)‐conjugated targeted block copolymers, FA‐Pluronic‐polycaprolactone (FA‐Pluronic‐PCL) are synthesized in this study. The paclitaxel (PTX) is loaded FA‐Pluronic‐PCL nanoparticles by nanoprecipitation method. vitro release of PTX from shows slow and sustained behaviors. effect FA ligand density on targeting properties examined...