A5075387929- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Adipose Tissue and Metabolism
- Photoreceptor and optogenetics research
- Neural dynamics and brain function
- Regulation of Appetite and Obesity
- Neuroendocrine regulation and behavior
- Memory and Neural Mechanisms
- Neuroscience and Neural Engineering
- Circadian rhythm and melatonin
- Neurological disorders and treatments
- Biochemical Analysis and Sensing Techniques
- Zebrafish Biomedical Research Applications
- Stress Responses and Cortisol
- Diet and metabolism studies
- Eating Disorders and Behaviors
- Neuropeptides and Animal Physiology
- Pharmacological Effects and Assays
- Sleep and Wakefulness Research
- Animal Behavior and Welfare Studies
- Neural and Behavioral Psychology Studies
- EEG and Brain-Computer Interfaces
- Neuroinflammation and Neurodegeneration Mechanisms
- Bat Biology and Ecology Studies
Washington University in St. Louis
2019-2025
Emory University
2025
National Institute of Diabetes and Digestive and Kidney Diseases
2014-2021
National Institutes of Health
2013-2020
National Institute on Drug Abuse
2014-2019
National Institute on Alcohol Abuse and Alcoholism
2018
Gladstone Institutes
2010-2016
University of California, San Francisco
2012-2016
University of Pennsylvania
2006-2009
The direct and indirect efferent pathways from striatum ultimately reconverge to influence basal ganglia output nuclei, which in turn regulate behavior via thalamocortical brainstem motor circuits. However, the distinct contributions of these two shaping are not well understood. We investigated processes using selective optogenetic control pathways, combination with single-unit recording nucleus substantia nigra pars reticulata (SNr) mice. Optogenetic activation striatal pathway projection...
Abstract Torpor is an energy-conserving state in which animals dramatically decrease their metabolic rate and body temperature to survive harsh environmental conditions. Here, we report the noninvasive, precise safe induction of a torpor-like hypothermic hypometabolic rodents by remote transcranial ultrasound stimulation at hypothalamus preoptic area (POA). We achieve long-lasting (>24 h) mice via closed-loop feedback control with automated detection temperature. Ultrasound-induced...
Cachexia, a severe wasting syndrome associated with inflammatory conditions, often leads to multiorgan failure and death. Patients cachexia experience extreme fatigue, apathy, clinical depression, yet the biological mechanisms underlying these behavioral symptoms their relationship disease remain unclear. In mouse cancer model, specifically induced increased effort-sensitivity, apathy-like through cytokine-sensing brainstem-to-basal ganglia circuit. This neural circuit detects elevated...
Highlights•Brain-wide influences of direct and indirect pathways are visualized with ofMRI•Direct pathway stimulations evoke opposing brain-wide activities•Direct exert non-canonical control over STN GPi•BOLD signal polarity reflects single-unit activity in basal ganglia thalamusSummaryA central theory function is that striatal neurons expressing the D1 D2 dopamine receptors influences. However, causal influence each population has never been measured at whole-brain scale. Here, we...
Feeding is critical for survival, and disruption in the mechanisms that govern food intake underlies disorders such as obesity anorexia nervosa. It important to understand both motivation reveal underlying feeding disorders. Operant behavioral testing can be used measure motivational component feeding, but most monitoring systems do not operant behavior. Here, we present a new solution rodent home-cages: Experimentation Device version 3 (FED3). FED3 measures behavior home-cages, enabling...
The central adenosine system and receptors play a fundamental role in the modulation of dopaminergic neurotransmission. This is mostly achieved by strategic co-localization different dopamine receptor subtypes two populations striatal efferent neurons, striatonigral striatopallidal, that give rise to direct indirect pathways, respectively. With optogenetic techniques it has been possible dissect differential pathways mediating "Go" responses upon exposure reward-related stimuli "NoGo"...
Heightened aggression can be serious concerns for the individual and society at large are symptoms of many psychiatric illnesses, such as post-traumatic stress disorder. The circuit synaptic mechanisms underlying experience-induced increase, however, poorly understood. Here we find that prior attack experience leading to an increase in aggressive behavior, known priming, activates neurons within posterior ventral segment medial amygdala (MeApv). Optogenetic stimulation MeApv using a...
Agouti-related peptide (AgRP) neurons increase motivation for food, however, whether metabolic sensing of homeostatic state in AgRP potentiates by interacting with dopamine reward systems is unexplored. As a model impaired metabolic-sensing, we used the AgRP-specific deletion carnitine acetyltransferase (Crat) mice. We hypothesised that required to food modulating accumbal or striatal release. Studies confirmed Crat (KO) ex vivo glucose-sensing, as well responses peripheral glucose injection...
Advancing our understanding of brain function and developing treatments for neurological diseases hinge on the ability to modulate neuronal groups in specific areas without invasive techniques. Here, we introduce Airy-beam holographic sonogenetics (AhSonogenetics) as an implant-free, cell type–specific, spatially precise, flexible neuromodulation approach freely moving mice. AhSonogenetics utilizes wearable ultrasound devices manufactured using 3D-printed metasurfaces. These are designed...
Background Although extensive research has demonstrated the importance of excitatory granule neurons in dentate gyrus hippocampus normal learning and memory pathogenesis amnesia Alzheimer's disease (AD), role hilar GABAergic inhibitory interneurons, which control neuron activity, remains unclear. Methodology Principal Findings We explored function interneurons spatial by inhibiting their activity through Cre-dependent viral expression enhanced halorhodopsin (eNpHR3.0)—a light-driven chloride...