A5054028246- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience and Neural Engineering
- Neural dynamics and brain function
- Advanced Fluorescence Microscopy Techniques
- Neuroscience, Education and Cognitive Function
- Nerve injury and regeneration
- Neuroscience and Neuropharmacology Research
- Photoreceptor and optogenetics research
- Conducting polymers and applications
- Genetic Neurodegenerative Diseases
- Diet and metabolism studies
- Various Chemistry Research Topics
- Innovative Teaching Methods
- Receptor Mechanisms and Signaling
- Adipose Tissue and Metabolism
- Functional Brain Connectivity Studies
Center for the Neural Basis of Cognition
2015-2020
Clarion University
2020
Carnegie Mellon University
2014-2020
Parkinson’s disease (PD) is a progressive neurodegenerative disorder whose cardinal motor symptoms are attributed to dysfunction of basal ganglia circuits under conditions low dopamine. Despite well-established physiological criteria define dysfunction, correlations between individual parameters and often weak, challenging their predictive validity causal contributions behavior. One limitation that pathophysiology studied only at end-stages depletion, leaving an impoverished understanding...
This work introduces a novel method to detect spike oscillations amidst neural noise. Using this method, we demonstrate that delta in the basal ganglia are defining feature of awake, dopamine-depleted mice and strongly correlated with dopamine loss parkinsonian motor symptoms. These arise from D2-receptor activation do not require cortex. Similar human patients may be an underappreciated marker target for Parkinson’s disease (PD) treatment.
A silicon neural probe fabricated using a deep reactive ion etching based process on 250 μm thin wafers was developed. The probes replicate the design of soft parylene-C embedded in dissolvable needles and can therefore also be used to test encapsulation properties in-vivo without introducing additional effects introduced by gel. demonstrates possibility performing conventional photolithography substrates bonded handle wafer backgrinding liquid wax (BGL7080) as an adhesive. This technique...
Abstract Delta oscillations (0.5–4 Hz) are a robust but often overlooked feature of basal ganglia pathophysiology in Parkinson’s disease and their relationship to parkinsonian akinesia has not been investigated. Here, we establish novel approach detect spike embedded noise provide the first study delta awake, dopamine depleted mice. We find that approximately half neurons substantia nigra reticulata exhibit depletion these strong indicator loss akinesia, outperforming measures such as...