A5054017151- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Liver Diseases and Immunity
- Helicobacter pylori-related gastroenterology studies
- Liver Disease and Transplantation
- Social and Educational Sciences
- Gastrointestinal motility and disorders
- Hepatitis B Virus Studies
- Drug-Induced Hepatotoxicity and Protection
- Liver physiology and pathology
- Systemic Lupus Erythematosus Research
- HIV/AIDS drug development and treatment
- Aortic aneurysm repair treatments
- Proteoglycans and glycosaminoglycans research
- Celiac Disease Research and Management
- Drug Transport and Resistance Mechanisms
- Infectious Aortic and Vascular Conditions
- Gastroesophageal reflux and treatments
- Eosinophilic Esophagitis
- Asthma and respiratory diseases
- Inflammatory Bowel Disease
- Mycobacterium research and diagnosis
- Microscopic Colitis
- Immunodeficiency and Autoimmune Disorders
- Bacterial Identification and Susceptibility Testing
Colorado Permanente Medical Group
2020
Kaiser Permanente
2015-2019
Länssjukhuset Sundsvall-Härnösand
2018
Kaiser Permanente San Diego Medical Center
2014-2015
Umeå University
2010
Sundsvall Municipality
1993-2008
Lund University
2007
Uppsala University Hospital
1983-1996
Stockholm University College of Music Education
1996
Uppsala University
1984-1988
The interferon-free regimen of ABT-450 with ritonavir (ABT-450/r), ombitasvir, and dasabuvir or without ribavirin has shown efficacy in inducing a sustained virologic response phase 2 study involving patients hepatitis C virus (HCV) genotype 1 infection. We conducted two 3 trials to examine the safety this previously untreated HCV infection no cirrhosis.
Recent animal studies show that endothelial cells in liver sinusoids are the main site for removal of sodium hyaluronate from circulation. Few data with respect to metabolism available man. Serum levels were measured 119 patients disease by a sensitive assay. The level was significantly increased cirrhosis, comparison healthy controls and noncirrhotic disease. results suggest role human elimination Quantification serum may be useful test cell function.
We randomly assigned 159 patients with non-ulcer dyspepsia, defined as chronic or recurrent epigastric pain without concomitant symptoms of the irritable bowel syndrome and no evidence organic disease, to treatment for three weeks an antacid suspension one hours after meals, 400 mg cimetidine twice a day, placebo, according double-blind, double-dummy model. The intensity duration were recorded by four times daily during one-week period therapy treatment. mean reduction in placebo group was...
Risks and benefits of simeprevir plus sofosbuvir (SIM+SOF) in patients with advanced cirrhosis are unknown. We assessed the safety sustained virological responses (SVR) SIM+SOF without ribavirin (RBV) Child‐Pugh (CP)‐B/C versus CP‐A compared to matched untreated controls. This study was a multicenter cohort adults hepatitis C virus genotype 1 treated with/without RBV for 12 weeks. Controls were on treatment center, age, CP class, Model End‐Stage Liver Disease (MELD) score. Of 160 RBV, 35%...
To evaluate serum hyaluronate as a marker for progressive liver injury in patients with primary biliary cirrhosis, longitudinal study including 48 was conducted mean follow-up time of 40 months. The were examined every 6 months standardized set conventional function tests, and biopsy performed year. concentration correlated significantly (p < 0.001) albumin, t 1/2 galactose tolerance test, bilirubin prothrombin but not to variables reflecting inflammatory activity. Furthermore, there...
The clinical features and outcome of primary biliary cirrhosis (PBC) during long term follow-up study (mean, 9 years; range, 1–20 years) was reviewed in 80 patients. Seventy per cent were asymptomatic at initial presentation. the mortality symptomatic group 63%, compared with 20% (p < 0.001). presence hepatomegaly histopathology consistent stage 2–4 asymtomatic cases a prognostically ominous sign, as these patients often developed symptoms finding 1, however, correlated an excellent...
An attempt was made to estimate the total costs of non-ulcer dyspepsia (NUD) in Sweden by extracting information from different available sources. After extrapolation figures in-patient register University Hospital Uppsala whole Sweden, annual expenditure for care estimated be 10.3 million SEK. Calculations out-patient and drugs were based on data a nation-wide sample survey, expenses 197.5 SEK 60 SEK, respectively. Among indirect social costs, economic losses due death early retirement...
Nonucler dyspepsia lacks a clear definition, and probably conceals several entities under this heading. It seems appropriate to deal separately with symptoms likely be elicited from the upper digestive tract. Therefore, we propose "epigastric distress syndrome" (EDS) as designation for chronic or recurrent epigastric pain without any anatomical antecedents concomitant consistent established criteria of irritable bowel syndrome. In study 185 dyspeptic patients tentative diagnosis EDS, based...
We used two-color and three-color flow cytometric analysis to study phenotypical activation functional subsets of T natural killer cells in the blood liver tissue patients with primary biliary cirrhosis, other chronic diseases healthy subjects. The changes lymphocyte phenotype cirrhosis were similar comprised elevated relative or absolute numbers activated human leukocyte antigen-DR+ subset (CD4+ CD8+) DR+ killer-like (CD16+) cells. B cell (CD19+) normal. In a selective reduction...
As previous reports show an association of chronic hepatitis C (HCV) with hepatocellular carcinoma (HCC) and non-liver cancers, we examine the HCV liver cancer cancers.Retrospective cross-sectional study at Kaiser Permanente Southern California (KPSC) evaluating non-HCV patients from 1 January 2008 to 12 December 2012. Cancer diagnoses were obtained KPSC-SEER-affiliated registry. Logistic regression analyses used for rate ratios time-to-event performed using Cox proportional hazards models,...
Nonalcoholic fatty liver disease (NAFLD) is a global public health problem. However, the natural history of NAFLD incomplete. This retrospective cohort study patients identified with by diagnosis codes in large, community-based care delivery system. The objectives were (1) to follow from initial presentation through progression cirrhosis and/or decompensated cancer, transplant, and death for up 10 years; (2) conduct analysis restricted as having diabetes at baseline. A total 98,164 full...
In 44 patients with primary biliary cirrhosis serum levels of vitamin A, retinol-binding protein and transthyretin (prealbumin) were found to be significantly lower than in 25 sex- age-matched controls. Liver biopsies available for chemical analyses 28 the patients. Their mean liver A concentration (2.8 +/- 2.0 mumoles per gm wet weight) did not differ from that 22 cases sudden death which served as controls (2.0 1.5 weight). Immunohistochemical investigation showed a normal distribution...
Summary Objectives To identify the epidemiology and antifungal susceptibilities of Candida spp. among blood culture isolates to in Sweden. Methods The study was a retrospective, observational nationwide laboratory‐based surveillance for fungaemia fungal meningitis conducted from September 2015 August 2016. Results In total, 488 were obtained 471 patients (58% males). Compared our previous study, incidence candidaemia has increased 4.2/100 000 (2005‐2006) 4.7/100 population/year (2015‐2016)....
The variation of the serum concentration hyaluronan during day and between days has been investigated. In a group healthy volunteers, mean level was very stable over time except for moderate but significant elevation after rising from bed in morning. Patients with rheumatoid arthritis showed markedly increased concentrations 0.5-2 h leaving bed. primary biliary cirrhosis exhibited high rather constant levels day. A reference hospitalized patients other diseases did not show any diurnal...
The health care resources required by patients clinically considered to have gastritis were studied during a 3-year period. assessment was based on data from nationwide sample study covering all outpatient in Sweden. Gastritis, the fourth commonest diagnosis general practice, accounted for 2% of consultations and 31% those gastroenterological disorders. estimated minimal number annual 4500 per 100,000 inhabitants. Seventy-two cent with had previously sought medical advice similar symptoms....
Risk factors for prepyloric and duodenal ulcer were analysed by means of a questionnaire in 132 patients population controls, pairwise matched age sex. Several associated with lower socioeconomic status, such as short education, low income housing standard, job characterized satisfaction, demands, autonomy, more prevalent among the patients. The odds ratio (OR) 95% confidence limits (CL) smokers versus non-smokers was 2.9 (CL, 1.7-5.0). A trend emerged relation to daily number cigarettes, an...
Three strains of a previously undescribed catalase-positive non-lipophilic coryneform bacterium isolated from human clinical specimens were characterized by phenotypic and molecular taxonomic methods. Morphologically the unknown consisted pleomorphic rods, some which displayed bulges/knobs at their ends. All three similar in that they produced acid fructose, glucose, maltose sucrose urease-positive. Chemotaxonomic investigations revealed presence meso-diaminopimelic short-chain mycolic acids...
Abstract A series of compounds based on a novel fluorescent scaffold have been synthesized. Most the displayed high quantum yields fluorescence and unusually long lifetimes. HeLa cells were treated with one its use as dye was demonstrated confocal microscopy.