A5049334882- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Immune Cell Function and Interaction
- Dermatology and Skin Diseases
- IL-33, ST2, and ILC Pathways
- Mitochondrial Function and Pathology
- Historical and modern epidemiology studies
- Meta-analysis and systematic reviews
- Food Security and Health in Diverse Populations
- Urticaria and Related Conditions
- Obesity and Health Practices
- Autophagy in Disease and Therapy
- Asthma and respiratory diseases
- Food Allergy and Anaphylaxis Research
- Health Promotion and Cardiovascular Prevention
- Immune cells in cancer
- Metabolism, Diabetes, and Cancer
- T-cell and B-cell Immunology
- Metabolism and Genetic Disorders
- Wound Healing and Treatments
- Single-cell and spatial transcriptomics
- Muscle metabolism and nutrition
- Eosinophilic Esophagitis
- Retinoids in leukemia and cellular processes
- Cancer, Hypoxia, and Metabolism
Washington University in St. Louis
2017-2025
The University of Texas at San Antonio
2024
Barnes-Jewish Hospital
2022
Cornell University
2014-2018
Missouri Baptist University
2017
Hanyang University
2017
Medical College of Wisconsin
2017
University of Pennsylvania
2012-2015
Skidmore College
2008-2015
Institute of Immunology
2013
The type 2 inflammatory response is induced by various environmental and infectious stimuli. Although recent studies identified group innate lymphoid cells (ILC2s) as potent sources of cytokines, the molecular pathways controlling ILC2 responses are incompletely defined. Here we demonstrate that murine ILC2s express β2-adrenergic receptor (β2AR) colocalize with adrenergic neurons in intestine. β2AR deficiency resulted exaggerated inflammation intestinal lung tissues. Conversely, agonist...
Type 2 inflammation underlies allergic diseases such as atopic dermatitis, which is characterized by the accumulation of basophils and group innate lymphoid cells (ILC2s) in inflamed skin lesions. Although murine studies have demonstrated that cutaneous basophil ILC2 responses are dependent on thymic stromal lymphopoietin, whether these cell populations interact to regulate development type poorly defined. In this study, we identify ILC2s significantly accumulate human form clusters not...
Aiding and abetting norovirus disease Norovirus is highly infectious usually causes transient, acute disease. In some individuals, persists associated with inflammatory bowel disorders. While investigating the cell tropism for murine norovirus, Wilen et al. discovered that a rare type, tuft cells, carrying CD300lf receptor were virus's specific target. Tuft cells proliferate in response to type 2 cytokines interleukin-4 interleukin-25, which thereby amplify infection. Moreover, infected are...
The skin harbors complex communities of resident microorganisms, yet little is known their physiological roles and the molecular mechanisms that mediate cutaneous host-microbe interactions. Here, we profiled transcriptomes mice reared in presence absence microbiota to elucidate range pathways functions modulated by microbiota. A total 2820 genes were differentially regulated response microbial colonization enriched gene ontology (GO) terms related host-immune epidermal differentiation....
Abstract Torpor is an energy-conserving state in which animals dramatically decrease their metabolic rate and body temperature to survive harsh environmental conditions. Here, we report the noninvasive, precise safe induction of a torpor-like hypothermic hypometabolic rodents by remote transcranial ultrasound stimulation at hypothalamus preoptic area (POA). We achieve long-lasting (>24 h) mice via closed-loop feedback control with automated detection temperature. Ultrasound-induced...
OBJECTIVE Peripheral insulin resistance is linked to an increase in reactive oxygen species (ROS), leading part the production of lipid aldehydes that modify side chains protein amino acids a reaction termed carbonylation. The primary enzymatic method for aldehyde detoxification via glutathione S-transferase A4 (GSTA4) dependent glutathionylation. objective this study was evaluate expression GSTA4 and role(s) carbonylation adipocyte function. RESEARCH DESIGN AND METHODS GSTA4-silenced 3T3-L1...
The predominantly epithelial cell–derived cytokines IL-25, IL-33, and thymic stromal lymphopoietin (TSLP) can promote CD4+ Th2 cell–dependent immunity, inflammation, tissue repair at barrier surfaces through the induction of multiple innate immune cell populations. IL-25 IL-33 were previously shown to elicit four populations, named natural helper cells, nuocytes, type 2 multipotent progenitor (MPPtype2) now collectively termed group lymphoid cells (ILC2). In contrast other types ILC2,...
Objective Unrefined, complex carbohydrates and lean protein diets are used to combat obesity, although it's unknown whether more frequent meals may improve this response. The effects of consuming traditional (∼15%) versus higher (∼35%) intakes as three or six meals/day on abdominal fat, postprandial thermogenesis (TEM), cardiometabolic biomarkers in overweight individuals during 28 days energy balance (BAL) deficit (NEG), respectively were compared. Design Methods Overweight ( n = 30)...
Patients with atopic dermatitis harbor deficiencies in subsets of NK cells that can be therapeutically reversed to improve disease mice.
Dietary fiber improves metabolic health, but host-encoded mechanisms for digesting fibrous polysaccharides are unclear. In this work, we describe a mammalian adaptation to dietary chitin that is coordinated by gastric innate immune activation and acidic chitinase (AMCase). Chitin consumption causes distension cytokine production stomach tuft cells group 2 lymphoid (ILC2s) in mice, which drives the expansion of AMCase-expressing zymogenic chief facilitate digestion. Although influences gut...
Obesity predisposes to cancer and a virtual universality of nonalcoholic fatty liver disease (NAFLD). However, the impact hepatic steatosis on metastasis is enigmatic. We find that while control mice were relatively resistant metastasis, those which lipodystrophic or obese, with NAFLD, had dramatic increase in breast melanoma metastases. NAFLD promotes by reciprocal activation initiated tumor-induced triglyceride lipolysis juxtaposed hepatocytes. The lipolytic products are transferred cells...