A5055846733- Thyroid Cancer Diagnosis and Treatment
- Head and Neck Anomalies
- Thyroid and Parathyroid Surgery
- Neuroendocrine Tumor Research Advances
- Spectroscopy Techniques in Biomedical and Chemical Research
- Pancreatic and Hepatic Oncology Research
- Lymphoma Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Radiomics and Machine Learning in Medical Imaging
- BRCA gene mutations in cancer
- Thyroid Disorders and Treatments
- Gastrointestinal disorders and treatments
- Spectroscopy and Chemometric Analyses
- Gastric Cancer Management and Outcomes
- Photoacoustic and Ultrasonic Imaging
- Immune Cell Function and Interaction
- Global Cancer Incidence and Screening
- S100 Proteins and Annexins
- Parathyroid Disorders and Treatments
- CAR-T cell therapy research
- Biomedical Text Mining and Ontologies
- Molecular Biology Techniques and Applications
- AI in cancer detection
- Cutaneous Melanoma Detection and Management
Campus Bio Medico University Hospital
2015-2025
Sapienza University of Rome
1989-2025
Università Campus Bio-Medico
2014-2023
John Wiley & Sons (United States)
2020
Creative Commons
2017
Ospedale Israelitico
2011-2015
Ospedale Regina Apostolorum
2005-2014
CTO Andrea Alesini
2014
Azienda Ospedaliera Sant'Andrea
2011
Calcutta Research Group
2010
The aim of the study was to correlate sonographic [ultrasound (US)] and color-Doppler (CFD) findings with results US-guided fine needle aspiration biopsy (FNA) pathologic staging resected carcinomas establish: 1) relative importance US features as risk factors malignancy; 2) a cost-effective management nonpalpable thyroid nodules. Four hundred ninety-four consecutive patients nodules (8–15 mm) were evaluated by US, CFD, US-FNA. Ninety-two inadequate cytology excluded from study. All...
Benign thyroid nodules are a common clinical occurrence and usually do not require treatment unless symptomatic. During the last years, ultrasound-guided minimally invasive treatments (MIT) gained an increasing role in management of causing local symptoms. In February 2018, Italian MIT Thyroid Group was founded to create permanent cooperation between international physicians dedicated research assistance on for nodules. The group drafted this list statements based literature review consensus...
PURPOSE: To evaluate in vivo the safety and effectiveness of percutaneous laser thermal ablation (LTA) debulking thyroid lesions. MATERIALS AND METHODS: Twenty-five adult patients at poor surgical risk with cold nodules (n = 8), autonomously hyperfunctioning 16), or anaplastic carcinoma 1) underwent LTA. One to four 21-gauge spinal needles were inserted ultrasonographic (US) guidance into A 300-μm-diameter quartz optical fiber was advanced through sheath needle. Nd:YAG used output power 3–5...
Molecular fine-needle aspiration (FNA) cytology diagnostics has the potential to address inherent limitation of FNA which is an indeterminate (atypia undetermined significance/follicular lesion significance follicular neoplasm) cytology. Because emerging role molecular diagnostics, European Thyroid Association convened a panel international experts review methodological aspects, indications, results, and limitations diagnostics. The reviewed evidence for diagnostic value mutation assessment...
Objective Thyroid ultrasound is crucial for clinical decision in the management of thyroid nodules. In this study, we aimed to estimate and compare performance ATA, AACE/ACE/AME ACR TI-RADS classifications discriminating nodules with high-risk cytology. Design Cross-sectional study. Methods 1077 undergoing fine-needle aspiration were classified according by an automated algorithm. Odds ratios (ORs) receiver operating characteristic (ROC) curves cytology categories (TIR3b, TIR4 TIR5)...
Raman spectroscopy shows great potential as a diagnostic tool for thyroid cancer due to its ability detect biochemical changes during development. This technique is particularly valuable because it non-invasive and label/dye-free. Compared molecular tests, analyses can more effectively discriminate malignant features, thus reducing unnecessary surgeries. However, one major hurdle using the identification of significant patterns peaks. In this study, we propose Machine Learning procedure...
To evaluate percutaneous interstitial laser photocoagulation (ILP) as a palliative treatment of recurrent thyroid carcinoma untreatable with surgery or radioiodine administration.By using 18 resected glands, the volume and histologic pattern ILP-induced damage were assessed. In vivo feasibility was evaluated by low-energy in two volunteers before thyroidectomy for huge autonomously functioning nodules. With ultrasonographic (US) monitoring, 21-gauge spinal needle inserted into A 300-microm...
We studied for 5 yr a homogeneous group of 83 patients randomly assigned to levothyroxine (l-T4) suppressive therapy or control evaluate changes in nodule thyroid size, appearance new nodules, and correlations with clinical parameters. In the group, mean volume increased significantly after (2.12 ± 1.46 vs. 0.77 mL), whereas treatment it decreased, although not (1.45 1.17 mL 1.53 0.61 mL). Baseline was different two groups, but significant difference observed at yr. After yr, sonograms...
Incidental papillary thyroid microcarcinoma (PTMC), a frequent clinical problem, is usually associated with favorable outcome. During long-term follow-up, only minority of cases show aggressive behavior either lymph node or distant metastases. Recently, we had an opportunity to evaluate the efficacy nonsurgical, ultrasound (US)-guided percutaneous laser ablation (PLA) for local treatment PTMC in otherwise inoperable patient.Neck US examination revealed incidental, solitary, 8 × 7 mm...
Only few studies analysed the capability of cytology in detecting medullary thyroid cancer (MTC), and they reported a low accuracy this diagnostic technique. Recently, calcitonin (CT) measurement aspiration needle washout (FNA-CT) neck lesions has been as sensitive tool for MTC. The aim study is to compare sensitivity FNA-CT MTC assess cut-off value clinical practice.Thirty-eight from 36 patients were retrospectively studied, diagnosed treated four different centres. Furthermore, 52...
Mini-invasive procedures may be useful for control of local neck nodal metastases papillary thyroid cancer (PTC) in high-risk patients. Our objective was to assess the effectiveness and safety ultrasound (US)-guided laser ablation (LA) nonsurgical treatment small-size PTC. We conducted a pilot study on surgically controlled metastasis, followed by prospective trial with 12-month follow-up. Participants included five patients previous total thyroidectomy dissection PTC, eight new lymph node...
The reported reliability of core needle biopsy (CNB) is high in assessing thyroid nodules after inconclusive fine-needle aspiration (FNA) attempts. However, first-line use CNB for considered at risk by ultrasonography (US) has yet to be studied. aim this study were: 1) evaluate the potential merit using instead conventional FNA with suspicious ultrasonographic features; 2) compare and as a diagnostic procedure lesions higher cancer. Seventy-seven patients suspicious-appearing, recently...
Background: No direct prospective studies comparing laser ablation (LA) and radiofrequency (RFA) for debulking benign non-functioning thyroid nodules (BNTNs) exist. We aimed at the efficacy safety of both techniques in patients with solid or predominantly BNTN. Methods: This six-month, single-use, randomized, open-label, parallel trial compared following primary endpoints between RFA LA groups six months after treatment: (i) nodule volume reduction expressed as a percentage baseline; (ii)...
Background: One of the most widely used risk stratification systems for estimating individual patients' persistent or recurrent differentiated thyroid cancer (DTC) is American Thyroid Association (ATA) guidelines. The 2015 ATA version, which has increased number patients considered at low intermediate risk, been validated in several retrospective, single-center studies. aims this study were to evaluate real-world performance system predicting response treatment 12 months after initial and...