A5046084794- Thyroid Cancer Diagnosis and Treatment
- Thyroid Disorders and Treatments
- Thyroid and Parathyroid Surgery
- Head and Neck Anomalies
- BRCA gene mutations in cancer
- Pituitary Gland Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Neuroendocrine Tumor Research Advances
- Hormonal and reproductive studies
- Radiomics and Machine Learning in Medical Imaging
- Myasthenia Gravis and Thymoma
- Cancer-related Molecular Pathways
- Adrenal Hormones and Disorders
- Prostate Cancer Treatment and Research
- Ophthalmology and Eye Disorders
- Adrenal and Paraganglionic Tumors
- S100 Proteins and Annexins
- Pharmacology and Obesity Treatment
- Biomarkers in Disease Mechanisms
- Erythrocyte Function and Pathophysiology
- Entomological Studies and Ecology
- Child Abuse and Related Trauma
- Sexual Differentiation and Disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Sexual function and dysfunction studies
University of Catania
2016-2025
Ospedale Garibaldi
1997-2024
Royal Marsden NHS Foundation Trust
2017-2019
IMPORTANCE Detection of asymptomatic thyroid nodules has increased.Consensus is lacking regarding the optimal follow-up cytologically proven benign lesions and sonographically nonsuspicious nodules.Current guidelines recommend serial ultrasound examinations reassessment cytology if significant growth observed.OBJECTIVE To determine frequency, magnitude, factors associated with changes in nodule size.DESIGN, SETTING, AND PARTICIPANTS Prospective, multicenter, observational study involving 992...
Routine serum calcitonin (CT) measurement in patients with thyroid nodules for diagnosis of medullary carcinoma (MTC) is controversial.The objective this study was to evaluate the diagnostic accuracy systematic CT non-multiple endocrine neoplasia type 2 nodular disease.This conducted at a national healthcare system hospital (outpatient and inpatient sectors).Consecutive disease (n = 5817) were studied.Serum levels measured under basal conditions, when values more than or equal 20 less 100...
The current use of life-long follow-up in patients with papillary thyroid cancer (PTC) is based largely on the study individuals diagnosed and treated latter half 20th century when recurrence rates were approximately 20% relapses detected up to 20-30 years after surgery. Since then, however, diagnosis, treatment, postoperative monitoring PTC have evolved significantly.The objective was identify times by which these occurred a more recent patient cohort.We retrospectively analyzed data for...
Persistent or recurrent disease is rare in low risk patients with papillary thyroid cancer, and follow-up of these a matter debate. Neck ultrasonography (US), serum thyroglobulin (Tg), whole body scan (WBS) after T4 withdrawal were performed 456 patients, followed up to 5 yr. At the end first year, 335 Tg negative, 121 positive; 65 96 levels between 1 10 ng/ml became spontaneously negative 2 During follow-up, WBS discovered node metastases 13 subjects, US 38 subjects (31 positive 7...
Serum thyroglobulin (Tg) assays are considered fundamental in postoperative surveillance of differentiated thyroid cancer (DTC) patients. However, the postsurgical profile Tg levels has never been specifically investigated patients who do not undergo radioiodine remnant ablation (RRA). Our objective was to explore evolution over time DTC treated with total or near-total thyroidectomy without RRA. We retrospectively analyzed 290 consecutively diagnosed cases low-risk (American Thyroid...
Context: Most papillary thyroid microcarcinomas (PTMCs; ≤ 1 cm diameter) are indolent low-risk tumors, but some cases behave more aggressively. Controversies have thus arisen over the optimum postoperative surveillance of PTMC patients.
Objective: The association between papillary thyroid cancer (PTC) and Hashimoto's thyroiditis is widely recognized, but less known about the possible link circulating anti-thyroglobulin antibody (TgAb) titers PTC aggressiveness. To shed light on this issue, we retrospectively examined a large series of patients with without positive TgAb. Methods: Data 220 TgAb-positive (study cohort) were collected in 10 hospital-based referral centers. All had undergone near-total thyroidectomy or...
Background: One of the most widely used risk stratification systems for estimating individual patients' persistent or recurrent differentiated thyroid cancer (DTC) is American Thyroid Association (ATA) guidelines. The 2015 ATA version, which has increased number patients considered at low intermediate risk, been validated in several retrospective, single-center studies. aims this study were to evaluate real-world performance system predicting response treatment 12 months after initial and...
Abstract Thyroid carcinomas, even when well differentiated, usually appear as hypofunctioning at scintigraphy. We report a case of an aggressive insular thyroid carcinoma presenting autonomously functioning nodule and causing severe thyrotoxicosis. The tumor was metastatic to cervical lymph node both lungs. An activating mutation the TSH receptor gene in primary metastasis found, due base substitution codon 633 (normal guanine position 1896 replaced by cytosine CAC for GAC aspartic acid...
Objectives: The goal of evidence-based practice guidelines is to optimize the management emerging diseases, such as differentiated thyroid cancer (DTC). aim this study was assess therapeutic approaches for DTC in Italy and see how closely these practices conformed those recommended 2009 American Thyroid Association (ATA) guidelines. Methods: Italian Cancer Observatory established collect data prospectively on cancers consecutively diagnosed participating centers (uniformly distributed across...
Abstract Context The risk stratification of patients with differentiated thyroid cancer (DTC) is crucial in clinical decision making. most widely accepted method to assess recurrent/persistent disease described the 2015 American Thyroid Association (ATA) guidelines. However, recent research has focused on inclusion novel features or questioned relevance currently included features. Objective To develop a comprehensive data-driven model predict persistent/recurrent that can capture all...
Previous reports indicate that selenium supplementation may be useful to reduce cell oxidative stress. In particular, decrease the level of thyroid autoantibodies in patients with Hashimoto's thyroiditis (HT). Recent studies also myo-inositol have beneficial effects on function HT. Hence, aim present study is evaluate whether enhance protective effect HT progression hypothyroidism. The was designed as observational and retrospective. Thyroid hormones were evaluated who either euthyroid or...
Background: The role of minimal extrathyroidal extension (mETE) as a risk factor for persistent papillary thyroid carcinoma (PTC) is still debated. aims this study were to assess the clinical impact mETE predictor worse initial treatment response in PTC patients and verify radioiodine therapy after surgery with mETE. Methods: We reviewed all records Italian Thyroid Cancer Observatory database selected 2237 consecutive who satisfied inclusion criteria (PTC no lymph node metastases at least 1...
Abstract Context The risk of recurrence papillary thyroid carcinoma smaller than 1 cm (microPTC) is low. Predictors disease persistence in microPTC are still unclear. Objective To compare the clinical and pathological characteristics microPTCs with macrocarcinomas (PTC > cm), identifying predictors biochemical structural incomplete response one year after initial treatment microPTC. Methods We included patients consecutively enrolled Italian Thyroid Cancer Observatory (NCT04031339),...
Azoospermia factor (AZF) region microdeletions, which account for about 10–15% of patients with oligoazoospermia, seem to lack a close genotype–testicular phenotype correlation. Although many genetic and non-genetic factors may contribute this outcome, it was thought that spontaneous regression testicular germ cells might also play relevant role. The opportunity carrying out two different biopsies one year apart in an AZFc-microdeleted patient enabled corroboration possibility. Indeed, the...
Serum thyroglobulin (Tg) stimulation by recombinant human TSH (rhTSH), in combination with neck ultrasonography (US), is an important tool the first follow-up of differentiated epithelial cell thyroid carcinoma (DTC) patients. The objective this study was to investigate if a second rhTSH stimulation, performed 2-3 years later, clinical utility these patients.One hundred and one consecutive ambulatory DTC patients were studied. great majority them (89/101) low-risk patients, being stage I or...