A5014123674- Thyroid Cancer Diagnosis and Treatment
- Thyroid Disorders and Treatments
- Thyroid and Parathyroid Surgery
- Neuroendocrine Tumor Research Advances
- Head and Neck Anomalies
- Pituitary Gland Disorders and Treatments
- Erythrocyte Function and Pathophysiology
- Monoclonal and Polyclonal Antibodies Research
- Growth Hormone and Insulin-like Growth Factors
- Ophthalmology and Eye Disorders
- Cancer-related Molecular Pathways
- Ion channel regulation and function
- Vestibular and auditory disorders
- T-cell and B-cell Immunology
- BRCA gene mutations in cancer
- Neonatal Health and Biochemistry
- Advanced Breast Cancer Therapies
- Neuroblastoma Research and Treatments
- Cell Adhesion Molecules Research
- Glycosylation and Glycoproteins Research
- Metabolism, Diabetes, and Cancer
- Diet, Metabolism, and Disease
- Prostate Cancer Treatment and Research
- Glaucoma and retinal disorders
- Salivary Gland Tumors Diagnosis and Treatment
Institut Jules Bordet
2015-2024
Université Libre de Bruxelles
1985-2024
Magna Graecia University
2008-2019
Nini Hospital
2009
University of Reggio Calabria
1991-1997
San Francisco VA Medical Center
1996
University of California, San Francisco
1991-1996
United States Department of Veterans Affairs
1993-1995
University of Catania
1991
Ospedale Garibaldi
1991
IMPORTANCE Detection of asymptomatic thyroid nodules has increased.Consensus is lacking regarding the optimal follow-up cytologically proven benign lesions and sonographically nonsuspicious nodules.Current guidelines recommend serial ultrasound examinations reassessment cytology if significant growth observed.OBJECTIVE To determine frequency, magnitude, factors associated with changes in nodule size.DESIGN, SETTING, AND PARTICIPANTS Prospective, multicenter, observational study involving 992...
Routine serum calcitonin (CT) measurement in patients with thyroid nodules for diagnosis of medullary carcinoma (MTC) is controversial.The objective this study was to evaluate the diagnostic accuracy systematic CT non-multiple endocrine neoplasia type 2 nodular disease.This conducted at a national healthcare system hospital (outpatient and inpatient sectors).Consecutive disease (n = 5817) were studied.Serum levels measured under basal conditions, when values more than or equal 20 less 100...
The current use of life-long follow-up in patients with papillary thyroid cancer (PTC) is based largely on the study individuals diagnosed and treated latter half 20th century when recurrence rates were approximately 20% relapses detected up to 20-30 years after surgery. Since then, however, diagnosis, treatment, postoperative monitoring PTC have evolved significantly.The objective was identify times by which these occurred a more recent patient cohort.We retrospectively analyzed data for...
Persistent or recurrent disease is rare in low risk patients with papillary thyroid cancer, and follow-up of these a matter debate. Neck ultrasonography (US), serum thyroglobulin (Tg), whole body scan (WBS) after T4 withdrawal were performed 456 patients, followed up to 5 yr. At the end first year, 335 Tg negative, 121 positive; 65 96 levels between 1 10 ng/ml became spontaneously negative 2 During follow-up, WBS discovered node metastases 13 subjects, US 38 subjects (31 positive 7...
Serum thyroglobulin (Tg) assays are considered fundamental in postoperative surveillance of differentiated thyroid cancer (DTC) patients. However, the postsurgical profile Tg levels has never been specifically investigated patients who do not undergo radioiodine remnant ablation (RRA). Our objective was to explore evolution over time DTC treated with total or near-total thyroidectomy without RRA. We retrospectively analyzed 290 consecutively diagnosed cases low-risk (American Thyroid...
Small papillary thyroid carcinomas have contributed to the worldwide increased incidence of differentiated cancer observed over past decades. However, mortality rate has not changed same period time, raising questions about possibility that patients, especially those with small tumors, are overdiagnosed and overtreated. Molecular prognostic marker able discriminate aggressive cancers from an indolent course would be great relevance tailor therapeutic approach reduce overtreatment. Mutations...
Context: Most papillary thyroid microcarcinomas (PTMCs; ≤ 1 cm diameter) are indolent low-risk tumors, but some cases behave more aggressively. Controversies have thus arisen over the optimum postoperative surveillance of PTMC patients.
Objective: The association between papillary thyroid cancer (PTC) and Hashimoto's thyroiditis is widely recognized, but less known about the possible link circulating anti-thyroglobulin antibody (TgAb) titers PTC aggressiveness. To shed light on this issue, we retrospectively examined a large series of patients with without positive TgAb. Methods: Data 220 TgAb-positive (study cohort) were collected in 10 hospital-based referral centers. All had undergone near-total thyroidectomy or...
Context: The European Thyroid Association (ETA) has classified posttreatment cervical ultrasound findings in thyroid cancer patients based on their association with disease persistence/recurrence. Objective: objective of the study was to assess this classification's ability predict growth and persistence such lesions during active surveillance differentiated (DTC). Design: This a retrospective, observational study. Setting: conducted at center large Italian teaching hospital. Patients:...
Current surgical standard of care in sporadic medullary thyroid carcinoma (sMTC) consists a minimum total thyroidectomy with central neck dissection. Some have suggested lobectomy isthmusectomy and dissection for patients sMTC, given their lower frequency bilateral disease, although this topic has not been thoroughly studied. This study assessed the prevalence multifocality sMTC via large international multi-institutional retrospective review to quantify prevalence, including impact...
Thyroid nodules presenting as hot at 131I-scintigraphy are usually benign follicular adenomas. We report a 42-year-old female patient with an autonomously functioning Hürthle cell thyroid carcinoma causing thyrotoxicosis. Genetic analysis of her tumoral DNA revealed heterozygotic activating mutation the thyrotropin receptor (TSHR) gene that was located downstream to all other genetic alterations currently identified, and is due base substitution codon 677 (normal cytosine replaced by...
We studied the suitability of using recombinant human TSH receptor expressed in Chinese hamster ovary cells a binding inhibition (TBI) assay for autoantibodies against receptor. Purified immunoglobulin G (IgG) containing potent thyroid-stimulating bioactivity competed radiolabeled to parallel by unlabeled TSH. Using polyethylene glycol-prepared IgG, this discriminated very well between sera from normal individuals [TBI, 0.98 ± 0.04 (± sd); range, 0.92–1.08; n = 35] and patients with...
A relationship between vestibular disorders and thyroid autoimmunity independently from function has been postulated.To shed more light on the actual lesions Hashimoto's thyroiditis (HT) regardless of function.Forty-seven patients with HT (89·4% F; aged 48·3 ± 12·7 years), 21 multinodular goitre (MNG; 57·1% 54·1 9·8 years) 30 healthy volunteers (56·7% 50·7 13·9 were enrolled. Inclusion criteria presence normal tests no clinical history dysfunction. Each subject was submitted to complete...
Abstract Learning Objectives After completing this course, the reader will be able to: Compare guideline recommendations regarding use of routine calcitonin screening to diagnose medullary thyroid carcinoma patients with clinical risk factors.Select for whom may an appropriate diagnostic approach. CME This article is available continuing medical education credit at CME.TheOncologist.com Because its poor prognosis and high mortality rate, early diagnosis (MTC) a challenge. For almost two...
Summary Context In multiple endocrine neoplasia (MEN), re arranged during t ransfection ( RET ), gene testing has been extensively exploited to characterize tumour aggressiveness and optimize the diagnostic clinical management. Objective To report underlying genetic alterations in an unusual case of MEN type 2 (MEN‐2A). Design patient Occult medullary thyroid carcinoma (MTC) was diagnosed a 44‐year‐old man who had presented with unilateral phaeochromcytoma. DNA extracted from blood tissues...