A5016192801- Thyroid Cancer Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Thyroid Disorders and Treatments
- Cancer-related Molecular Pathways
- MicroRNA in disease regulation
- Celiac Disease Research and Management
- Genetic factors in colorectal cancer
- Adrenal and Paraganglionic Tumors
- Thyroid and Parathyroid Surgery
- Microscopic Colitis
- Cancer, Hypoxia, and Metabolism
- Pituitary Gland Disorders and Treatments
- Cancer-related molecular mechanisms research
- Radiomics and Machine Learning in Medical Imaging
- Biomarkers in Disease Mechanisms
- Neuroblastoma Research and Treatments
- Extracellular vesicles in disease
- Hormonal Regulation and Hypertension
- BRCA gene mutations in cancer
- Cancer Genomics and Diagnostics
- Diabetes and associated disorders
- Cancer-related gene regulation
- Circular RNAs in diseases
- Bioinformatics and Genomic Networks
- Pancreatic function and diabetes
Sapienza University of Rome
2015-2024
Policlinico Umberto I
2005-2024
ASL Roma
2022
Università Campus Bio-Medico
2012
Weatherford College
2011
Abstract Context: BRAF mutations are common in papillary thyroid carcinomas (PTCs). By affecting the expression of genes critically related to development and differentiation cancer, they may influence prognosis these tumors. Objective: Our objective was characterize thyroid-specific associated with mutation PTCs. Design/Setting Patients: We examined key markers thyrocyte 56 PTCs (BRAF-mut) 37 wild-type (BRAF-wt). Eight samples normal tissue were analyzed as controls. Quantitative PCR used...
Trends toward more conservative management of papillary thyroid cancer (PTC) diminish the primacy serum thyroglobulin (Tg) assays as a posttreatment surveillance tool. To identify tumor-associated microRNAs (miRNAs) in with potential for development unique biomarkers PTC recurrence. We measured expression 754 miRNAs samples collected from 11 patients before and 30 days after thyroidectomy. Major candidates were then re-evaluated by absolute quantitative polymerase chain reaction analysis an...
MicroRNA (miRNA) expression is dysregulated in many human malignancies, and a growing number of studies are focused on their potential use as tumor biomarkers. To identify miRNA signature for papillary thyroid carcinomas (PTC), we investigated profiles two independent cohorts PTCs, which included major histological subtypes [classical-type (PTC‑CT), follicular-variant (PTC‑FV), tall-cell variant (PTC‑TCV)] cases with low or intermediate risk recurrence. Using TaqMan® Array Human A+B Cards...
Type 2 deiodinase (D2) converts T4 in T3 several human tissues, including hypothalamus and pituitary, and, therefore, plays a pivotal role the negative feedback regulation of TSH secretion. A common variant gene, threonine (Thr) 92 alanine (Ala), has been identified associated with decreased D2 enzymatic activity.Our objective was to investigate whether this polymorphism predicts dosage needed obtain target levels thyroidectomized patients.Ambulatory patients were included study.A total 191...
Context: The European Thyroid Association (ETA) has classified posttreatment cervical ultrasound findings in thyroid cancer patients based on their association with disease persistence/recurrence. Objective: objective of the study was to assess this classification's ability predict growth and persistence such lesions during active surveillance differentiated (DTC). Design: This a retrospective, observational study. Setting: conducted at center large Italian teaching hospital. Patients:...
Abstract Context Ultrasonography (US) is considered the most sensitive tool for imaging persistent or recurrent papillary thyroid cancer (PTC) in neck. Objective To clarify usefulness of routine neck US low- and intermediate-risk patients with PTC no evidence disease 1 year after thyroidectomy. Design Retrospective analysis prospectively recorded data. Setting Academic center. Patients Two hundred twenty-six sonographically normal lymph nodes unstimulated serum thyroglobulin (Tg) levels that...
ABSTRACT Objectives: The prevalence of celiac disease (CD) among the relatives and complications an undiagnosed CD prompted us to identify a useful screening strategy. Methods: We studied 441 first degree 208 patients by immunoglobulin (Ig)A antiendomysium antibodies (EMA) radioimmunoprecipitation assay (RIA) IgA antitransglutaminase autoantibodies (TGAA). Of these, 364 were typed for human leukocyte antigen‐DRB1, ‐DQA1, ‐DQB1 genes polymerase chain reaction sequence specific primers method....
Abstract Cancer stem-like cells (CSCs) have self-renewal abilities responsible for cancer progression, therapy resistance, and metastatic growth. The glioblastoma are the most studied among CSC populations. A recent study identified four transcription factors (SOX2, SALL2, OLIG2, POU3F2) as minimal core sufficient to reprogram differentiated (GBM) into cells. Transcriptomic data of GBM tissues cell lines from two different datasets were then analyzed by SWItch Miner (SWIM), a network-based...
Advanced medullary thyroid cancers (MTCs) are now being treated with drugs that inhibit receptor tyrosine kinases, many of which involved in angiogenesis. Response rates vary widely, and toxic effects common, so treatment should be reserved for MTCs likely to responsive these drugs. RET mutations common MTCs, but it is unclear how they influence the microvascularization tumors. We examined 45 germ-line or somatic (RETmut group) 34 wild-type (RETwt). Taqman Low-Density Arrays were used assess...
Summary Context In multiple endocrine neoplasia (MEN), re arranged during t ransfection ( RET ), gene testing has been extensively exploited to characterize tumour aggressiveness and optimize the diagnostic clinical management. Objective To report underlying genetic alterations in an unusual case of MEN type 2 (MEN‐2A). Design patient Occult medullary thyroid carcinoma (MTC) was diagnosed a 44‐year‐old man who had presented with unilateral phaeochromcytoma. DNA extracted from blood tissues...
Novel molecularly targeted drugs are undergoing preclinical and clinical testing to assess their efficacy against refractory thyroid carcinomas. The multikinase inhibitor Sunitinib has been shown inhibit the kinase activity of RET oncogene reduce proliferation in differentiated cancer cells harboring RET/PTC rearrangement. In this study, we evaluated its effects human cell lines derived from (TPC-1) anaplastic (8505C, CAL-62, C643) cancers.The exposed various concentrations were examined...