A5039117361- Immune Cell Function and Interaction
- Oral Health Pathology and Treatment
- Immunotherapy and Immune Responses
- Salivary Gland Disorders and Functions
- Reproductive System and Pregnancy
- T-cell and B-cell Immunology
- Head and Neck Cancer Studies
- Oral and Maxillofacial Pathology
- Cancer and Skin Lesions
- Immune Response and Inflammation
- Telomeres, Telomerase, and Senescence
- IL-33, ST2, and ILC Pathways
- Dermatology and Skin Diseases
- Cytomegalovirus and herpesvirus research
- Endometriosis Research and Treatment
- Ectopic Pregnancy Diagnosis and Management
- Ideological and Political Education
- Advanced biosensing and bioanalysis techniques
- Salivary Gland Tumors Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Herpesvirus Infections and Treatments
- Soil and Water Nutrient Dynamics
- Genetics, Aging, and Longevity in Model Organisms
- RNA modifications and cancer
- Aquaculture disease management and microbiota
Wuhan University
2007-2025
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2024
Nanjing Medical University
2009-2024
Jiangsu Province Hospital
2012-2024
Lanzhou University
2024
Lanzhou University Second Hospital
2024
Renmin Hospital of Wuhan University
2024
First Affiliated Hospital of Nanchang University
2024
Nanchang University
2024
Ministry of Education of the People's Republic of China
2024
Abstract Understanding and dissecting the role of different subsets regulatory tumor-infiltrating lymphocytes (TILs) in immunopathogenesis individual cancer is a challenge for anti-tumor immunotherapy. High levels γδ T cells have been discovered breast TILs. However, clinical relevance these intratumoral unknown. In this study, cell populations were analyzed by performing immunohistochemical staining primary tissues from patients with stages progression. Retrospective multivariate analyses...
Patients with atopic dermatitis harbor deficiencies in subsets of NK cells that can be therapeutically reversed to improve disease mice.
Abstract Biochemical properties of soil organic matter (SOM) are fundamental for fertility and health. However, it is unclear how fertilization regime influences the biochemical compositions oxidation states SOM physical fractions. In this study, issue was studied under four 32-year amendment regimes: unfertilized control, urea (N), N + calcium dihydrogen phosphate potassium chloride (NPK), NPK plus manure (NPKM). Three fractions: coarse particulate (> 250 μm, cPOM), fine (53–250 fPOM)...
The initial process in liver regeneration after partial hepatectomy involves the recruitment of immune cells and release cytokines. Osteopontin (OPN), a pro-inflammatory protein, plays critical roles cell activation migration. Although OPN has been implicated pathogenesis many diseases, role remains obscure. In present study, we found that serum hepatic protein levels were significantly elevated wild-type (WT) mice (PHx) bile ductal epithelia major source OPN. Compared to WT mice, knockout...
Abstract Objective The presence, in patients with primary and secondary Sjögren's syndrome (SS), of autoantibodies that acutely inhibit M 3 muscarinic receptor (M3R)–mediated bladder contractions is difficult to reconcile the fact symptoms detrusor overactivity other features cholinergic hyperresponsiveness occur this disease. This study was undertaken examine vivo effects these on function by examining responsiveness compliance following passive transfer patient IgG mice. Methods...
The aim of the present study is to investigate effects dietary Lycium barbarum polysaccharides (LBPs) supplementation on growth performance, immune response, serum antioxidant status, and intestinal health weaned piglets. In total, 24 crossed healthy piglets [Duroc × (Yorkshire Landrace)], similar body weight (7.47 ± 0.22 kg), were randomly allocated three treatment groups: CON (basal diet); LBPs diet plus 4,000 mg/kg LBPs); antibiotic (ABO, basal 20 flavomycin 50 quinocetone). There eight...
Tregs are key drivers of immunosuppression in solid tumors. As an important chemokine receptor on Tregs, the regulatory effect CCR8 tumor immunity has received more and attention. However, current research immune microenvironment ovarian cancer not been clear.Bioinformatics analysis was used to compare transcriptome differences between CD4+ T cells peripheral circulation infiltrated tissues. RT-PCR detect expression levels receptor-related differential genes blood Multiparameter flow...
Oral lichen planus (OLP) is a T-cell-mediated chronic inflammatory disease with uncertain aetiology. Mucosal-associated invariant T (MAIT) cells and γδT are unconventional, innate-like immunoregulatory capacity. This study aimed to investigate the potential effects of MAIT on pathogenesis OLP.Circulating were identified using flow cytometry. Surface proteins including CD4, CD8, CD69, CD103, CD49d, programmed death-1 (PD-1) its ligand PD-L1 assessed. Cytokines containing interleukin (IL)-4,...
Oral lichen planus (OLP) is a chronic, immune-mediated inflammatory disease involving T cells. Mitochondrial fission plays crucial role in cell fate through structural remodeling. Nicotinamide adenine dinucleotide (NAD+) regulates mitochondrial remodeling and function. This study explored the of NAD+ modulating apoptosis cells under OLP immune-inflammatory environment. plasma were isolated from peripheral blood. morphology was characterized by transmission electron microscopy Mito-Tracker...
Abstract Background and Aims Inflammageing represents both a critical pathophysiological hallmark independent risk factor for myocardial infarction (MI), with age‐related increases observed in MI incidence severity of post‐MI ventricular remodelling. Novel therapeutic strategies targeting inflammageing‐driven mechanisms are urgently required to attenuate adverse remodelling following MI. This investigation was designed elucidate the impact fibroblast‐specific p16 INK4a on...
Tumor survival is significantly correlated with the immune response of patients. IFNG plays an important role in tumor host and decreased expression often observed lung cancer. Studies have shown that CpG island hypermethylation a critical transcriptional silencing gene expression. However, there limited understanding regarding molecular mechanisms altered methylation, whether microenvironment has any effect on DNA methylation production. In current study, we demonstrate plasma...
NLRP3 inflammasomes- pyroptosis axis is activated by microcirculation dysfunction and touched off severe acute pancreatitis (SAP). Activation of PGC-1α can improve promoting mitochondrial biogenesis. Resveratrol (RSV), one typical SIRT1 agonist, possesses the ability alleviating SAP activing PGC-1α. Therefore, study was designated to explore whether protective effect RSV in though suppressing via advancing SIRT1/PGC-1α-dependent The models were induced treating with sodium taurodeoxycholate...
Oral lichen planus (OLP) is an immune-inflammatory disease mediated by T cells. Innate lymphoid cells (ILCs) constitute a novel family of immune that initially originate from common innate progenitors. Termed “T counterparts,” ILCs play prominent role in inflammatory-immune diseases. However, the characterization and their related induced factors were unclear OLP. In present study, phenotypic characteristics correlation with inflammatory cytokines explored peripheral blood OLP patients...