A5101468464- RNA Research and Splicing
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- interferon and immune responses
- Cancer-related molecular mechanisms research
- SARS-CoV-2 and COVID-19 Research
- Global Health Care Issues
- MicroRNA in disease regulation
- Neuroendocrine Tumor Research Advances
- RNA regulation and disease
- T-cell and B-cell Immunology
- Virology and Viral Diseases
- Reproductive Biology and Fertility
- Health Systems, Economic Evaluations, Quality of Life
- Cancer Mechanisms and Therapy
- Genomics and Phylogenetic Studies
- HIV Research and Treatment
- Cardiovascular Health and Disease Prevention
- Blood Pressure and Hypertension Studies
- Immune Cell Function and Interaction
- Virus-based gene therapy research
- Frailty in Older Adults
- Genomics and Chromatin Dynamics
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Lung Cancer Research Studies
Fudan University Shanghai Cancer Center
2025
Shanghai Medical College of Fudan University
2025
Tsinghua University
2017-2023
Center for Life Sciences
2017-2023
Zhongda Hospital Southeast University
2021
Anhui University
2020
Beijing Advanced Sciences and Innovation Center
2017
We present RISE (http://rise.zhanglab.net), a database of RNA Interactome from Sequencing Experiments. RNA-RNA interactions (RRIs) are essential for regulation and function. provides comprehensive collection RRIs that mainly come recent transcriptome-wide sequencing-based experiments like PARIS, SPLASH, LIGR-seq, MARIO, as well targeted studies RIA-seq, RAP-RNA CLASH. It also includes aggregated other primary databases publications. The currently contains 328,811 in human, mouse yeast. While...
Significance Familial esophageal squamous cell carcinoma (ESCC) often shows early onset and worse prognosis. Little is known about the genetic basis underlying pathogenesis of familial ESCC. To identify alterations associated with ESCC susceptibility, we compared gene-expression profiles sporadic ESCCs. We found that A-to-I RNA editing–mediated downregulation SLC22A3 almost exclusively present in may serve as a potential biomarker for patients. Molecular mechanism study further revealed...
Abstract Background Vertebrate early embryogenesis is initially directed by a set of maternal RNAs and proteins, yet the mechanisms controlling this program remain largely unknown. Recent transcriptome-wide studies on RNA structure have revealed its pervasive crucial roles in processing functions, but whether how regulates fate transcriptome to be determined. Results Here we establish global map four nucleotide-based mRNA structures icSHAPE during zebrafish embryogenesis. Strikingly, observe...
Significance We established a genome-wide CRISPR library and RNA interference for bat species performed two genetic screens to uncover host factors of cells involved in virus infections. Although the viruses methodologies used were different screens, we identified one common protein, MTHFD1, as broad-spectrum factor. Further studies show that MTHFD1 inhibitor, carolacton, can potently inhibit variety viruses, including SARS-CoV-2. provide resource studying functional genomics biology.
Recent reports have shown the critical role of mitochondrial antiviral signaling (MAVS) protein in virus-induced apoptosis, but involvement MAVS tumorigenesis is still poorly understood. Herein, we report that a key regulator p53 activation and for protecting against tumorigenesis. We find promotes p53-dependent cell death response to DNA damage. interacts with mediates recruitment under genotoxic stress. Mechanistically, inhibits ubiquitination by blocking formation p53-murine double-minute...
Small cell lung cancer (SCLC) is a highly malignant subtype with dismal prognosis and limited treatment options. This study aimed to identify new prognostic molecular biomarkers for SCLC explore their immune-related implications strategies. We analyzed 200 samples via whole-exome sequencing (WES) 313 by targeted sequencing. A smoking-related SBS4 mutational signature was linked poorer lower tumor burden (TMB), while the APOBEC-mediated SBS13 associated better higher TMB. identified worst...
Abstract The relationship between conventional lipid parameters and arterial stiffness (AS) has been verified by previous studies. However, it remains unknown whether non‐conventional have certain predictive effect on AS represented brachial‐ankle pulse wave velocity (baPWV). Therefore, the study was to explore remnant cholesterol (RC) other in general population free from cardiovascular disease. included 912 participants aged 24–84 years a medical health checkup center of Murakami Memorial...
RNA molecules play crucial roles in various biological processes. Their regulation and function are mediated by interacting with other molecules. Among them RNA-RNA interactions (RRIs) important many basic cellular activities including transcription, processing, localization, translation. However, we just start to unveil the complexity of knowledge underlying mechanisms RRIs. In this review, will summarize approaches for RRI identifications, both conventional, focused biophysical biochemical...
SUMMARY Bats are responsible for the zoonotic transmission of several major viral diseases including 2003 SARS outbreak and ongoing COVID-19 pandemic. While bat genomic sequencing studies have revealed characteristic adaptations innate immune system, functional urgently needed to provide a foundation molecular dissection tolerance infections in bats. Here we report establishment screening genome-wide RNAi library CRISPR model megabat, Pteropus Alecto . We used complementary libraries...
The aging of the population has led to a rapid increase in prevalence most neurological diseases between 1990 and 2016, with growth rate up 117%, which put enormous pressure on medical insurance funds. As one core disease diagnosis grouping, hospitalization cost composition grouping research patients cerebral ischemic can help determine scientific payment standards reduce economic burden patients.We aimed understand influencing factors hospitalized identify reasonable scheme.The data come...
Early embryogenesis in vertebrates is initially directed by maternal RNAs and proteins, yet the mechanisms controlling this program remain largely unknown. Recent transcriptome-wide studies on RNA structure have revealed its pervasive crucial roles processing functions. Here we established first global map of four nucleotide-based mRNA structures during zebrafish early embryogenesis. Strikingly, observed structurally variable regions are enriched 3’ UTR, contain cis-regulatory elements...
Abstract RNA‐RNA interactions (RRIs) are essential to understanding the regulatory mechanisms of RNAs. Mapping RRIs in vivo a transcriptome‐wide manner remained challenging until recent development several sequencing‐based technologies. However, generated from large‐scale studies had not been systematically collected and analyzed before. This article introduces RISE, database RNA Interactome Sequencing Experiments. RISE provides comprehensive collection human, mouse, yeast, derived...