A5100338577- RNA modifications and cancer
- Acute Myeloid Leukemia Research
- Cancer Genomics and Diagnostics
- NF-κB Signaling Pathways
- Cancer Cells and Metastasis
- RNA Interference and Gene Delivery
- Cancer-related Molecular Pathways
- Cancer, Hypoxia, and Metabolism
- RNA Research and Splicing
- CRISPR and Genetic Engineering
- PI3K/AKT/mTOR signaling in cancer
- Ubiquitin and proteasome pathways
- Advanced Breast Cancer Therapies
- Lymphoma Diagnosis and Treatment
- Wnt/β-catenin signaling in development and cancer
- Reproductive Biology and Fertility
- DNA Repair Mechanisms
- Cancer-related gene regulation
- Pluripotent Stem Cells Research
- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- RNA and protein synthesis mechanisms
- Cancer Research and Treatments
- Peptidase Inhibition and Analysis
- Virus-based gene therapy research
Duke University
2015-2025
Chungbuk National University
2024-2025
Duke University Hospital
2013-2025
Duke Medical Center
2013-2025
University of Nebraska Medical Center
2024
Dongguk University
2015-2024
Samsung (South Korea)
2023-2024
Chungbuk National University Hospital
2024
Pusan National University Yangsan Hospital
2019-2023
Soonchunhyang University
2023
Intratumor heterogeneity is a major clinical problem because tumor cell subtypes display variable sensitivity to therapeutics and may play different roles in progression. We previously characterized 2 populations human breast tumors with distinct properties: CD44+CD24- cells that have stem cell-like characteristics, CD44-CD24+ resemble more differentiated cancer cells. Here we identified 15 genes required for growth or proliferation large-scale loss-of-function screen found inhibition of...
During the evolution of metazoans and rise systemic hormonal regulation, insulin-controlled class 1 phosphatidylinositol 3OH-kinase (PI3K) pathway was merged with primordial amino acid-driven mammalian target rapamycin (mTOR) to control growth development organism. Insulin regulates mTOR function through a recently described canonical signaling pathway, which is initiated by activation PI3K. However, how acid input integrated that insulin unclear. Here we used number molecular, biochemical,...
The PI3K signaling pathway regulates diverse cellular processes, including proliferation, survival, and metabolism, is aberrantly activated in human cancer. As such, numerous compounds targeting the are currently being clinically evaluated for treatment of cancer, several have shown some early indications efficacy breast However, resistance against these agents, both de novo acquired, may ultimately limit compounds. Here, we taken a systematic functional approach to uncovering potential...
In February 2016, the World Health Organization declared a Public Emergency of International Concern on Zika Virus (ZIKV), because its association with severe fetal anomalies congenitally infected humans. This has led to urgent efforts by academic, federal, and industry research groups improve our understanding pathogenesis ZIKV develop detection methods, therapeutic strategies, vaccines. Although we still do not have entire picture ZIKV, extensive been conducted related pathogenic...
Ectopic Wnt signaling induces increased stem/progenitor cell activity in the mouse mammary gland, followed by tumor development. The receptors, Lrp5/6, are uniquely required for canonical activity. Previous data has shown that absence of Lrp5 confers resistance to Wnt1-induced development.Here, we show all basal cells express Lrp5, and co-express Lrp6 a similar fashion. Though dependent transcription key target genes is relatively unchanged epithelial cultures, specifically depletes adult...
In the search for a new thermogelling biomaterial, we are reporting poly(ethylene glycol)−poly(trimethylene carbonate) (PEG−PTMC) diblock copolymers. The PEG−PTMC (550−2750) copolymer aqueous solutions (>25 wt %) underwent sol-to-gel-to-syneresis (macroscopic phase separation between polymer and water) transition as temperature increased. sol-to-gel could be controlled in range of 20−75 °C by varying concentration water, molecular weight, composition polymer. 13C NMR spectra, transmission...
3q26 is frequently amplified in several cancer types with a common region containing 20 genes. To identify driver genes this region, we interrogated the function of each these by loss- and gain-of-function genetic screens. Specifically, found that TLOC1 (SEC62) was selectively required for proliferation cell lines amplification. Increased expression induced anchorage-independent growth, second gene, SKIL (SNON), facilitated invasion immortalized human mammary epithelial cells. Expression...