A5089272343- COVID-19 Clinical Research Studies
- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
- Multilevel Inverters and Converters
- Syphilis Diagnosis and Treatment
- Neuroscience and Neural Engineering
- Neurological disorders and treatments
- Diabetes and associated disorders
- SARS-CoV-2 and COVID-19 Research
- RNA modifications and cancer
- Autophagy in Disease and Therapy
- Reproductive tract infections research
- interferon and immune responses
- Liver Disease Diagnosis and Treatment
- Endoplasmic Reticulum Stress and Disease
- Ubiquitin and proteasome pathways
- Gear and Bearing Dynamics Analysis
- Immunodeficiency and Autoimmune Disorders
- Circular RNAs in diseases
- Cell Image Analysis Techniques
- Expert finding and Q&A systems
- Ferroptosis and cancer prognosis
- Actinomycetales infections and treatment
- Cellular transport and secretion
- Infectious Diseases and Mycology
303 Hospital of People's Liberation Army
2025
PLA Academy of Military Science
2025
Nanjing University of Chinese Medicine
2024
Northwestern Polytechnical University
2022-2023
Bengbu Medical College
2020-2022
Hangzhou Medical College
2020-2022
Zhejiang Provincial People's Hospital
2020-2022
Tumor Hospital of Guangxi Medical University
2019-2022
Academy of Military Medical Sciences
2020-2021
Guangxi Medical University
2021
Viral infection triggers the formation of mitochondrial antiviral signaling protein (MAVS) aggregates, which potently promote immune signaling. Autophagy plays an important role in controlling MAVS-mediated signaling; however, exact molecular mechanism underlying targeted autophagic degradation MAVS remains unclear. Here, we investigated by RNF34 regulates immunity and mitophagy targeting MAVS. binds to compartment after viral negatively RIG-I-like receptor (RLR)-mediated immunity. Moreover,...
The unfolded protein response (UPR) signal in tumor cells activates UPR signaling neighboring macrophages, which leads to tumor‐promoting inflammation by up‐regulating target genes and proinflammatory cytokines. However, the molecular basis of this endoplasmic reticulum (ER) stress transmission remains largely unclear. Here, we identified secreted form Golgi 73 (GP73), a Golgi‐associated functional critical for hepatocellular carcinoma (HCC) growth metastasis, is indispensable ER...
Abstract In this study, we specifically addressed the connection between SARS-CoV-2 virus with host cholesterol metabolism. Plasma lipid profile was measured in 861 COVID-19 patients classified as mild (n=215), moderate (n=364), severe (n=217) or critical (n=65) and 1108 age- sex-matched healthy individuals. We showed that levels of both TG HDL-C were significantly lower disease than disease. After successful treatment, metabolism reestablished infection. The serum concentrations TC can be...
Abstract The prevalence of non-obese nonalcoholic fatty liver disease (NAFLD) is increasing worldwide with unclear etiology and pathogenesis. Here, we show GP73, a Golgi protein upregulated in livers from patients variety diseases, exhibits Rab GTPase-activating (GAP) activity regulating ApoB export. Upon regular-diet feeding, liver-GP73-high mice display NAFLD phenotype, characterized by reduced body weight, intrahepatic lipid accumulation, gradual insulin resistance development, none which...
Essential tremor (ET) is the most prevalent movement disorder, with its incidence increasing age, significantly impacting motor functions and quality of life. Traditional methods for assessing ET severity are often time-consuming, subjective, require in-person visits to medical facilities. This study introduces a novel deep learning-based approach remotely using handwriting images, which improves both efficiency accessibility. We collected approximately 1000 high-quality Archimedean spiral...
Recent reports have shown the critical role of mitochondrial antiviral signaling (MAVS) protein in virus-induced apoptosis, but involvement MAVS tumorigenesis is still poorly understood. Herein, we report that a key regulator p53 activation and for protecting against tumorigenesis. We find promotes p53-dependent cell death response to DNA damage. interacts with mediates recruitment under genotoxic stress. Mechanistically, inhibits ubiquitination by blocking formation p53-murine double-minute...
As a critical immune checkpoint molecule, PD-L1 is expressed at significantly higher levels in multiple neoplastic tissues compared to normal ones. PD-L1/PD-1 axis target for tumor immunotherapy, blocking the recognized and has achieved unprecedented success clinical applications. However, efficacy of therapies targeting PD-1/PD-L1 pathway remains limited, emphasizing need mechanistic elucidation expression. In this study, we found that RNF125 interacted with regulated protein...
Abstract Introduction Mycoplasma pneumoniae is a common cause of respiratory infections in humans. The aim this study was to investigate the infection (MP) patients with acute tract Zhejiang Province from 2008 2017, and provide evidence for early diagnosis prevention MP pneumonia. Methods MP‐DNA detected nasopharyngeal swabs by real‐time fluorescent PCR (TaqMan probe). Statistical analysis epidemiological investigation were carried out on test results. Results There 10 296 Provincial...
Nocardia is an opportunistic pathogen, which occurs in patients with autoimmune diseases and immune dysfunction, can cause bacteremia other life-threatening complications. The clinical manifestations of pneumonia are similar to tuberculous common bacterial pneumonia, but its antibacterial treatments different detection methods unique, may lead suffer for many years due misdiagnosis missed diagnosis.Imaging laboratory examinations were performed preliminary diagnosis, next-generation...
Purpose The purpose of the paper is to investigate how cross-cultural elements such as cultural difference and stereotype are integrated into collaborative modes actions explore their corresponding effectiveness. Design/methodology/approach sample quantitative content analysis drawn from posts with topic China on Quora. A case, where two users have a question-and-answer interaction, taken unit analysis. effectiveness collaboration operationalized extent which collaboratively produced answer...
At present, there is no gold standard or unified for the diagnosis of neurosyphilis, and rate misdiagnosis high. The neurosyphilis still challenging. This study compared clinical indicators between latent syphilis infection in central nervous system. purpose this was to provide evidence differential prognosis patients with system.The data 59 30 system from 2008 2021 were analyzed. cerebrospinal fluid serum biochemical markers evaluated all patients.CSF-nucleated cells, CSF-TRUST,...
Parotid gland tuberculosis constantly results in unnecessary medical examinations and surgery because of its similarities the presentation to neoplasms parotid gland. Although involvement is extremely rare even tuberculosis-endemic countries, accurate diagnosis this clinical entity great significance tuberculous parotitis can be successfully treated medically without surgical therapy. Fine needle aspiration cytology (FNAC) molecular identification swellings are efficient making a rapid...
Recently, the rise of syphilitic seroresistance brings great confusion to clinical diagnosis and treatment syphilis, no clear diagnostic marker has been found distinguish from other progression syphilis. This study evaluated serum chemokines levels CCL2, CXCL8, CXCL9, CXCL10 its correlation with blood routine, coagulation, biochemical indexes in seroresistant patients.Serum were quantitatively determined by Flow Cytometric Bead Array (CBA). The results expressed pg/ml. Clinical parameters...
Abstract The recently emerged pathogenic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread rapidly, leading to a global COVID-19 pandemic. Binding of the viral spike protein (SARS-2-S) cell surface receptor angiotensin-converting enzyme (ACE2) mediates host infection. In present study, we demonstrate that in addition ACE2, S1 subunit SARS-2-S binds HDL and SARS-CoV-2 hijacks SR-B1-mediated uptake pathway facilitate its entry. SR-B1 facilitates entry into permissive...
Multiple myeloma (MM) is a cancer of plasma cells caused by abnormal gene expression and interactions within the bone marrow (BM) niche. The BM environment significantly influences progression MM. Celastrol, natural compound derived from traditional Chinese medicine, exhibits significant anticancer effects. This study aimed to identify specific targets celastrol develop more effective less toxic treatment options for Celastrol used as probe determine its target, pyridoxine-5'-phosphate...
Summary Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection induces new-onset diabetes and severe metabolic complications of pre-existing diabetes. The pathogenic mechanism underlying this is incompletely understood. Here, we provided evidence linking circulating GP73 with the exaggerated gluconeogenesis triggered by SARS-CoV-2 infection. We found that or glucotoxic condition increased cellular secretion GP73. Secreted trafficked to liver kidney stimulate through cAMP/PKA...
Objective To study the clinical application of three-dimensional (3D) visualization technology in liver resection complicated cancer. Methods A retrospective analysis 28 patients with cancer treated from June 2017 to 2018 Department Hepatobiliary Surgery, Affiliated Tumor Hospital Guangxi Medical University. There were 26 males and 2 females, aged (46±10) years old. A treatment plan on how perform for these was developed under guidance 3D technology. The actual surgical procedures,...
Dual-redundancy permanent magnet synchronous motors (DRPMSMs) are widely used in industrial applications due to the high reliability, however, dual-winding structure can cause phase current imblance between two stators, which may lead torque imbalance, increased motor ripple and degraded performance of control system. This paper proposes a method sharing for DRPMSM based on sliding-mode (SMC) with fuzzy logic control. While be achieved using fixed-parameter SMC control, robustness system is...
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection induces new-onset diabetes and severe metabolic complications of pre-existing diabetes. The pathogenic mechanism underlying this is incompletely understood. Here, we provided evidence linking circulating GP73 with the exaggerated gluconeogenesis triggered by SARS-CoV-2 infection. We found that or glucotoxic conditions increased production secretion. Secreted then trafficked to liver kidney stimulate through...
Abstract In recent years, the incidence of tumors has been increasing, and overall cure rate by traditional treatment methods does not exceed 20%. One most effective promising strategies for comprehensive is immunotherapy, such as with PD-1/PD-L1 antibody. Here, we showed that ring finger protein 125 (RNF125), an E3 ligase in RING domain family, could interact PD-L1 to reduce stability protein. addition, RNF125 downregulated expression promoting its ubiquitination at K48, whereas a mutation...