A5074703374- Advanced Wireless Communication Techniques
- Liver Disease Diagnosis and Treatment
- Drug Transport and Resistance Mechanisms
- Immune Cell Function and Interaction
- Immune cells in cancer
- Endoplasmic Reticulum Stress and Disease
- PAPR reduction in OFDM
- Pancreatic function and diabetes
- Enzyme Structure and Function
- Diabetes and associated disorders
- Power Line Communications and Noise
- Optical Network Technologies
- Blockchain Technology Applications and Security
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- RNA Research and Splicing
- SARS-CoV-2 detection and testing
- Graph Theory and Algorithms
- Poverty, Education, and Child Welfare
- Gender, Labor, and Family Dynamics
- Renal and related cancers
- RNA and protein synthesis mechanisms
- Protein Kinase Regulation and GTPase Signaling
- Radio Frequency Integrated Circuit Design
- Extracellular vesicles in disease
- Advanced Graph Neural Networks
Academy of Military Medical Sciences
2021-2025
University of North Texas
2022-2024
Purdue University West Lafayette
2015-2024
University of North Texas Health Science Center
2022-2024
Semiconductor Manufacturing International (China)
2022
Shenyang University of Technology
2022
Czech Academy of Sciences, Institute of Biotechnology
2021
Immunotherapy that targets immune checkpoints has achieved revolutionary success, but its application in solid tumors remains limited, highlighting the need for reliable enhancement of efficacy immunotherapy. Golgi protein 73 (GP73), a membrane protein, been implicated various cellular processes, including regulation. Recent studies suggested GP73 may play role modulating response patients with cancer. In this study, we investigated mechanism by which regulates T-cell-mediated antitumor...
Hyperlipidemia is a common metabolic disorder and regarded as one of the main risk factors for cardiovascular disease. The gut microbiota has been identified potential contributor to hyperlipidemia it can greatly regulate bile acid metabolism. Linderae radix natural medicine widely used in treatment variety diseases also drug hyperlipidemia. Recently, lipid-lowering effect are receiving increasing attention but underlying mechanism remains unknown. study aimed investigate effects ethanol...
Abstract The prevalence of non-obese nonalcoholic fatty liver disease (NAFLD) is increasing worldwide with unclear etiology and pathogenesis. Here, we show GP73, a Golgi protein upregulated in livers from patients variety diseases, exhibits Rab GTPase-activating (GAP) activity regulating ApoB export. Upon regular-diet feeding, liver-GP73-high mice display NAFLD phenotype, characterized by reduced body weight, intrahepatic lipid accumulation, gradual insulin resistance development, none which...
Folate receptors can perform folate transport, cell adhesion, and/or transcription factor functions. The beta isoform of the receptor (FRβ) has attracted considerable attention as a biomarker for immunosuppressive macrophages and myeloid-derived suppressor cells, however, its role in immunosuppression remains uncharacterized. We demonstrate here that FRβ cannot bind on healthy tissue macrophages, but does after macrophage incubation anti-inflammatory cytokines or cancer cell-conditioned...
We present algorithms of the channel and carrier frequency offset (CFO) estimation for burst-mode continuous phase modulation (CPM) transmission with optimized training waveforms, which are obtained through minimizing Cramer-Rao bound (CRB). Wirtinger calculus, provides a framework complex-valued signal processing, is used to simplify derivations CRBs maximum likelihood estimation. Unlike linear modulation, waveform not only respect modulated sequence but also sampling delay rate due CPM...
Maximal Frequent Subgraph (MFS) mining asks to identify the maximal subgraph that commonly appears in a set of graphs, which has been found valuable many applications social science, biology, and other domains. Previous studies focused on reducing search space MFSs discovered theoretically smallest space. Despite success theory, no practical algorithm can exhaustively as it is huge even for small graphs with only tens nodes hundreds edges. Moreover, deciding whether an MFS needs solve...
With the development of new energy, ancillary service demand power grid is increasing. The published literature focuses on building a blockchain market to ensure safety and efficiency transactions. However, due high threshold poor scalability, existing hard meet response rate services. Therefore, this paper proposes an energy storage capacity competition-based method in market. Firstly, structure proposed, which uses Proof Capacity (POC) as consensus mechanism. POC realize competition among...
Frequent Subgraph Mining is important in many scientific fields including molecular biology, genomics, and chemistry. Graphs are used to represent specific structures, by finding common subgraphs one can infer properties. Identification of maximum frequent subgraphs, therefore, provides an approach reveal hidden knowledge shared among graphs, classify graphs into informative categories. Most existing algorithms explicitly explore the subgraph space depth-first or breadth-first search,...
Background: In recent years, with the change in human dietary habits, hyperlipidemia (HLP) has become a common chronic disease. Hyperlipidemia is closely related to incidence of cardiovascular diseases. Due increasing and mortality from diseases, it imperative develop new medications for reducing lipid levels. With aim discovering treatment options hyperlipidemia, we conducted multi-omics analysis potential endogenous bile acid compound. Methods: Two models were established by feeding rats...
SARS-CoV-2 spike protein (SARS-2-S) induced cell–cell fusion in uninfected cells may occur long COVID-19 syndrome, as circulating SARS-2-S or extracellular vesicles containing (S-EVs) were found to be prevalent post-acute sequelae of (PASC) for up 12 months after diagnosis. Although isolated recombinant has been shown increase the SASP senescent ACE2-expressing cells, direct linkage syncytia with senescence absence virus infection and degree which affect pathology setting cardiac dysfunction...
Background: Inhibitor of MyoD family A (I-mfa) is a cytosolic protein. Its function in kidney unknown. The aim the present study was to examine regulatory role I-mfa on glomerular filtration rate (GFR). Methods: GFR measured by transdermal measurement FITC-sinitrin clearance conscious wild type (WT) and knockout (KO) mice. Cell contractility assessed single human or mouse mesangial cell. Single cell RNA sequence (scRNA-seq), Western blot, Ca 2+ imaging were used evaluate effects TRPCs at...
The RF inductor suffers from larger area and low Q-factor in CMOS process. With technology scaling down, the guard-ring design of is limited by BEOL double pattern process, which induces higher crosstalk coupling noise circuits. A novel closed multiple proposed based on SMIC FinFET about 60% lower, equivalent to 10% saving. Benefiting shielding effect, has 2-5% improvement.
Abstract Patients with pre-existing heart failure are at a particularly high risk of morbidity and mortality resulting from SARS-CoV-2 infection. Direct acute cardiac injury or cytokine storms have been proposed to contribute depressed function. However, the pathogenic mechanisms underlying increased vulnerability in infected patients still largely unknown. Here, we found that senescent outcome spike protein (SARS-2-S)-induced syncytia exacerbated progression. We first demonstrated syncytium...
Abstract Overexpression of mitotic kinase monopolar spindle 1 (Mps1) has been identified in many tumor types and targeting Mps1 for therapy shown great promise multiple preclinical cancer models. However, the role tamoxifen resistance breast never reported. Here this study, we report that determined sensitivity cells to treatment. overexpression rendered more resistant tamoxifen, while inhibitor or siMps1 oligos could overcome resistance. Mechanistically, interacted with ERα stimulated its...